Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19

Autor: Julie C. Wilson, David Kealy, Sally R. James, Tobias Plowman, Katherine Newling, Christopher Jagger, Kara Filbey, Elizabeth R. Mann, Joanne E. Konkel, Madhvi Menon, Sean B. Knight, Angela Simpson, Aliya Prihartadi, Greg Forshaw, Neil Todd, David R.A. Yates, John R. Grainger, Tracy Hussell, Paul M. Kaye, Nathalie Signoret, Dimitris Lagos

Publikováno v: iScience, Vol 25, Iss 1, Pp 103672- (2022)

Summary: Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized COVID-19 patients (Cohor

Externí odkaz: https://doaj.org/article/ae60124013314a368798f2b53c4974ad

A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development.

Autor: Tiffany Bouchery, Kara Filbey, Amy Shepherd, Jodie Chandler, Deepa Patel, Alfonso Schmidt, Mali Camberis, Adeline Peignier, Adam A T Smith, Karen Johnston, Gavin Painter, Mark Pearson, Paul Giacomin, Alex Loukas, Maria-Elena Bottazzi, Peter Hotez, Graham LeGros

Publikováno v: PLoS Pathogens, Vol 14, Iss 3, p e1006931 (2018)

As part of on-going efforts to control hookworm infection, the "human hookworm vaccine initiative" has recognised blood feeding as a feasible therapeutic target for inducing immunity against hookworm infection. To this end, molecular approaches have

Externí odkaz: https://doaj.org/article/4cf8b5ab6792453da2f872e631b2dec6

Alterations in T and B cell function persist in convalescent COVID-19 patients

Autor: Halima A. Shuwa, Tovah N. Shaw, Sean B. Knight, Kelly Wemyss, Flora A. McClure, Laurence Pearmain, Ian Prise, Christopher Jagger, David J. Morgan, Saba Khan, Oliver Brand, Elizabeth R. Mann, Andrew Ustianowski, Nawar Diar Bakerly, Paul Dark, Christopher E. Brightling, Seema Brij, Timothy Felton, Angela Simpson, John R. Grainger, Tracy Hussell, Joanne E. Konkel, Madhvi Menon, Rohan Ahmed, Miriam Avery, Katharine Birchall, Evelyn Charsley, Alistair Chenery, Christine Chew, Richard Clark, Emma Connolly, Karen Connolly, Simon Dawson, Laura Durrans, Hannah Durrington, Jasmine Egan, Kara Filbey, Claire Fox, Helen Francis, Miriam Franklin, Susannah Glasgow, Nicola Godfrey, Kathryn J. Gray, Seamus Grundy, Jacinta Guerin, Pamela Hackney, Chantelle Hayes, Emma Hardy, Jade Harris, Anu John, Bethany Jolly, Verena Kästele, Gina Kerry, Sylvia Lui, Lijing Lin, Alex G. Mathioudakis, Joanne Mitchell, Clare Moizer, Katrina Moore, Stuart Moss, Syed Murtuza Baker, Rob Oliver, Grace Padden, Christina Parkinson, Michael Phuycharoen, Ananya Saha, Barbora Salcman, Nicholas A. Scott, Seema Sharma, Jane Shaw, Joanne Shaw, Elizabeth Shepley, Lara Smith, Simon Stephan, Ruth Stephens, Gael Tavernier, Rhys Tudge, Louis Wareing, Roanna Warren, Thomas Williams, Lisa Willmore, Mehwish Younas

Publikováno v: Shuwa, H A, Shaw, T N, Knight, S B, Wemyss, K, McClure, F A, Pearmain, L, Prise, I, Jagger, C, Morgan, D J, Khan, S, Brand, O, Mann, E R, Ustianowski, A, Bakerly, N D, Dark, P, Brightling, C E, Brij, S, Felton, T, Simpson, A, Grainger, J R, Hussell, T, Konkel, J E & Menon, M 2021, ' Alterations in T and B cell function persist in convalescent COVID-19 patients ', Med, vol. 2, no. 6, pp. 720-735.E4 . https://doi.org/10.1016/j.medj.2021.03.013
Shuwa, H A, Shaw, T, Knight, S, Wemyss, K, Mcclure, F, Pearmain, L, Prise, I, Jagger, C, Morgan, D, Khan, S, Brand, O, Mann, E, Ustianowski, A, Diar Bakerly, N, Dark, P, Brightling, C E, Brij, S, Felton, T, Simpson, A, Grainger, J, Hussell, T, Konkel, J & Menon, M 2021, ' Alterations in T and B cell function persist in convalescent COVID-19 patients ', Med, vol. 2, no. 6, pp. 720-+ . https://doi.org/10.1016/j.medj.2021.03.013
Med (New York, N.y.)

Background Emerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined. Methods Here we desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b67c5628225813d3ceef6415c87a6c6
https://hdl.handle.net/20.500.11820/bb6608a9-a1e2-4f82-b861-0aceac9047c9