Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kara Anasti"'
Autor:
Camille N Pierre, Lily E Adams, Jaclyn S Higgins, Kara Anasti, Derrick Goodman, Dieter Mielke, Sherry Stanfield-Oakley, John M Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J Edwards, S Munir Alam, Guido Ferrari, Georgia D Tomaras, Barton F Haynes, Ralph S Baric, Kevin O Saunders
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1011569 (2024)
Antibodies perform both neutralizing and non-neutralizing effector functions that protect against certain pathogen-induced diseases. A human antibody directed at the SARS-CoV-2 Spike N-terminal domain (NTD), DH1052, was recently shown to be non-neutr
Externí odkaz:
https://doaj.org/article/d7d7ba6a7f484717a5dd976d5cd05be0
Autor:
Rory Henderson, Ye Zhou, Victoria Stalls, Kevin Wiehe, Kevin O. Saunders, Kshitij Wagh, Kara Anasti, Maggie Barr, Robert Parks, S. Munir Alam, Bette Korber, Barton F. Haynes, Alberto Bartesaghi, Priyamvada Acharya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with extensive sequence diversity. Vaccine desig
Externí odkaz:
https://doaj.org/article/a0c3383f4920484ea23242df323c4d69
Autor:
Rory Henderson, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, Hua-Xin Liao, Kevin O. Saunders, Mattia Bonsignori, Kevin Wiehe, Barton F. Haynes, S. Munir Alam
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational
Externí odkaz:
https://doaj.org/article/a47579b2b60d4216bca8f50e6239686f
Autor:
Kevin O. Saunders, Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R. Ryan Meyerhoff, Robert Parks, William E. Walkowicz, Baptiste Aussedat, Nelson R. Wu, Fangping Cai, Yusuf Vohra, Peter K. Park, Amanda Eaton, Eden P. Go, Laura L. Sutherland, Richard M. Scearce, Dan H. Barouch, Ruijun Zhang, Tarra Von Holle, R. Glenn Overman, Kara Anasti, Rogier W. Sanders, M. Anthony Moody, Thomas B. Kepler, Bette Korber, Heather Desaire, Sampa Santra, Norman L. Letvin, Gary J. Nabel, David C. Montefiori, Georgia D. Tomaras, Hua-Xin Liao, S. Munir Alam, Samuel J. Danishefsky, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2175-2188 (2017)
Summary: Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antib
Externí odkaz:
https://doaj.org/article/f020d40e9877461f93e8d9d15c7fa9e4
Autor:
Todd Bradley, Daniela Fera, Jinal Bhiman, Leila Eslamizar, Xiaozhi Lu, Kara Anasti, Ruijung Zhang, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Christina Stolarchuk, Krissey E. Lloyd, Robert Parks, Amanda Eaton, Andrew Foulger, Xiaoyan Nie, Salim S. Abdool Karim, Susan Barnett, Garnett Kelsoe, Thomas B. Kepler, S. Munir Alam, David C. Montefiori, M. Anthony Moody, Hua-Xin Liao, Lynn Morris, Sampa Santra, Stephen C. Harrison, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 43-54 (2016)
Antibodies that neutralize autologous transmitted/founder (TF) HIV occur in most HIV-infected individuals and can evolve to neutralization breadth. Autologous neutralizing antibodies (nAbs) against neutralization-resistant (Tier-2) viruses are rarely
Externí odkaz:
https://doaj.org/article/bc12b2e2dfd24166af9dc28af3fc9226
Autor:
Christa E Osuna, Ana Maria Gonzalez, Hsun-Hsien Chang, Amy Shi Hung, Elizabeth Ehlinger, Kara Anasti, S Munir Alam, Norman L Letvin
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004069 (2014)
Many of the factors that contribute to CD8+ T cell immunodominance hierarchies during viral infection are known. However, the functional differences that exist between dominant and subdominant epitope-specific CD8+ T cells remain poorly understood. I
Externí odkaz:
https://doaj.org/article/7cf9b4133b084058813f07d8150ad7ce
Autor:
James Friedman, S Munir Alam, Xiaoying Shen, Shi-Mao Xia, Shelley Stewart, Kara Anasti, Justin Pollara, Genevieve G Fouda, Guang Yang, Garnett Kelsoe, Guido Ferrari, Georgia D Tomaras, Barton F Haynes, Hua-Xin Liao, M Anthony Moody, Sallie R Permar
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37648 (2012)
Generation of potent anti-HIV antibody responses in mucosal compartments is a potential requirement of a transmission-blocking HIV vaccine. HIV-specific, functional antibody responses are present in breast milk, and these mucosal antibody responses m
Externí odkaz:
https://doaj.org/article/d9d8084dda2f4707b5a235ec76f608df
Autor:
Kevin O. Saunders, James Counts, Victoria Stalls, Robert Edwards, Kartik Manne, Xiaozhi Lu, Bhishem Thakur, Katayoun Mansouri, Yue Chen, Rob Parks, Maggie Barr, Laura Sutherland, Joena Bal, Nicholas Havill, Haiyan Chen, Emily Machiele, Nolan Jamieson, Bhavna Hora, Megan Kopp, Katarzyna Janowska, Kara Anasti, Chuancang Jiang, Sravani Venkatayogi, Amanda Eaton, Rory Henderson, Christopher Barbosa, S. Munir Alam, Sampa Santra, Drew Weissman, M. Anthony Moody, Derek W. Cain, Ying Tam, Mark Lewis, Wilton B. Williams, Kevin Wiehe, David Montefiori, Priyamvada Acharya, Barton F. Haynes
SUMMARYThe CD4 binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for many reasons, including the CD4bs is occlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4f4f461e186c69e94297d7dd514865
https://doi.org/10.2139/ssrn.4414883
https://doi.org/10.2139/ssrn.4414883
Autor:
Rory Henderson, Ye Zhou, Victoria Stalls, Kevin Wiehe, Kevin O. Saunders, Kshitij Wagh, Kara Anasti, Maggie Barr, Robert Parks, S. Munir Alam, Bette Korber, Barton F. Haynes, Alberto Bartesaghi, Priyamvada Acharya
Antibody affinity maturation enables adaptive immune responses to a wide range of pathogens. In some individuals broadly neutralizing antibodies develop to recognize rapidly mutating pathogens with extensive sequence diversity. Vaccine design for pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d5fabcebc243ce70ae03bcb2be7606c
https://doi.org/10.1101/2022.09.14.507935
https://doi.org/10.1101/2022.09.14.507935
Autor:
David R. Martinez, Alexandra Schäfer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, Maggie Barr, Victoria Stalls, Katarzyna Janowska, Esther Beaudoin, Kartik Manne, Katayoun Mansouri, Robert J. Edwards, Kenneth Cronin, Boyd Yount, Kara Anasti, Stephanie A. Montgomery, Juanjie Tang, Hana Golding, Shaunna Shen, Tongqing Zhou, Peter D. Kwong, Barney S. Graham, John R. Mascola, David C. Montefiori, S. Munir Alam, Gregory Sempowski, Gregory D. Sempowski, Surender Khurana, Kevin Wiehe, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes, Ralph S. Baric
Publikováno v:
Sci Transl Med
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2), including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality associated with sarbecovirus infection underscores the importance of developing broa