Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kara A Loiacono"'
Autor:
Ajit G Thomas, Rita Sattler, Karen Tendyke, Kara A Loiacono, Hans Hansen, Vishal Sahni, Yutaka Hashizume, Camilo Rojas, Barbara S Slusher
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0127785 (2015)
The cystine-glutamate antiporter (system xc-) is a Na+-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intrac
Externí odkaz:
https://doaj.org/article/b618d577c0344b50b94c5284688ad455
Autor:
Kristen Sanders, Janna Hutz, Hyeong-Wook Choi, Steven Mathieu, Dae-Shik Kim, Yongchun Shen, Thomas Noland, Yu Chen, Christy Ingersoll, Utpal Majumder, Xiaojie Zhu, Xingfeng Bao, Jiayi Wu, Karen TenDyke, Atsushi Endo, Nadeem Sarwar, So Yasui, Kuan-Chun Huang, Francis G. Fang, John Wang, Kara A. Loiacono, Ming-Hong Hao
Publikováno v:
ChemMedChem. 16:1741-1744
A strategy for creating potent and pan-genotypic stimulator of interferon genes (STING) agonists is described. Locking a bioactive U-shaped conformation of cyclic dinucleotides by introducing a transannular macrocyclic bridge between the nucleic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004795c53b9e23729fc448b3023672c0
https://doi.org/10.1002/cmdc.202100068
https://doi.org/10.1002/cmdc.202100068
Autor:
Dae-Shik Kim, Atsushi Endo, Renee R. Hukkanen, Muzaffar Akram, Donna Kolber-Simonds, Karen TenDyke, Diana I. Albu, Shannon McGrath, Vaishali Dixit, Christy Ingersoll, David Verbel, Frank Fang, Thomas Noland, Janna Hutz, Mark Matijevic, Xingfeng Bao, Chi Zhang, Dinesh Chandra, Jiayi Wu, Kara A. Loiacono, John Wang, Hao Ming-Hong, Nadeem Sarwar, Kuan-Chun Huang
Publikováno v:
Cancer Research. 79:3269-3269
Introduction: We report discovery and characterization of E7766, a structurally novel STING agonist, as a potential immunotherapy for solid cancers through intratumoral (IT) administration and for Bacillus Calmette-Guerin (BCG) unresponsive non-muscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed8346a200678c0d889467cdd3a87028
https://doi.org/10.1158/1538-7445.am2019-3269
https://doi.org/10.1158/1538-7445.am2019-3269
Autor:
Vishal Sahni, Ajit G. Thomas, Karen TenDyke, Camilo Rojas, Barbara S. Slusher, Yutaka Hashizume, Hans J. Hansen, Rita Sattler, Kara A. Loiacono
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0127785 (2015)
PLoS ONE, Vol 10, Iss 8, p e0127785 (2015)
The cystine-glutamate antiporter (system xc -) is a Na+-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a205e5fe66e2d2034d0b1460bffa0627
https://pubmed.ncbi.nlm.nih.gov/26252954
https://pubmed.ncbi.nlm.nih.gov/26252954
Autor:
Ian A. MacNeil, Berkley A. Lynch, Marie Rose van Schravendijk, Richard J. Rickles, Minor Charles A, Kara A. Loiacono, Mary K. Ram, T. B. Phillips, Susan Adams, Raji Sundaramoorthi, Dennis A. Holt
Publikováno v:
Analytical Biochemistry. 275:62-73
pp60 c-src is a prototypical nonreceptor tyrosine kinase and may play a role in diseases as diverse as cancer and osteoporosis. In Src, the SH3 domain (Src homology 3) binds proteins at specific, proline-rich sequences, while the SH2 domain (Src homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb4072a9cc1eea80983e9a4861f87b9
https://doi.org/10.1006/abio.1999.4305
https://doi.org/10.1006/abio.1999.4305
Autor:
Kara A. Loiacono, Ian A. MacNeil, Berkley A. Lynch, Taylor Merry, Chi B. Vu, Ukti Mani, Vaibhav Varkhedkar, John L. Buchanan, Dennis A. Holt, Selvaluxmi G. Pradeepan, Hilary R. Plake, Michael Yang, Evelyn G. Corpuz, Choi Lai Tiong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2359-2364
The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4- and 2,5-substituted thiazoles and 1,2,4-oxadiazoles as scaffolds resulted in inhibitors th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e24c3271625ce90015f47df8c67738d
https://doi.org/10.1016/s0960-894x(99)00389-3
https://doi.org/10.1016/s0960-894x(99)00389-3
Publikováno v:
Analytical Biochemistry. 247:77-82
The tyrosine kinase pp60c-srchas been implicated as being a potential therapeutic target in several human diseases including cancer and osteoporosis. An important region within this kinase is the SH2 domain (Src homology 2) which binds to phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84affa1ba81b263b62e8e36801235d44
https://doi.org/10.1006/abio.1997.2042
https://doi.org/10.1006/abio.1997.2042
Autor:
Kara A. Loiacono, Robert M. Goodman, Trudy H Grossman, Marcia S. Osburne, Choi Lai Tiong, Michelle R. Rondon, Michael Z. Gilman, Minor Charles A, Sean F. Brady, Jo Handelsman, Jon Clardy, Berkley A. Lynch, Alan D. Bettermann, Paul R. August, Ian A. MacNeil, Mark R. Liles
Publikováno v:
Applied and environmental microbiology. 66(6)
Recent progress in molecular microbial ecology has revealed that traditional culturing methods fail to represent the scope of microbial diversity in nature, since only a small proportion of viable microorganisms in a sample are recovered by culturing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6742679b1d74f97147e24a0079477f95
https://pubmed.ncbi.nlm.nih.gov/10831436
https://pubmed.ncbi.nlm.nih.gov/10831436