Výsledky vyhledávání - "Karène Argoud"

Akademický článek

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

Autor: Pamela J. Kaisaki, Georg W. Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Calderari, Marie-Thérèse Bihoreau, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 11, Pp 3671-3683 (2016)

To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown�

Externí odkaz: https://doaj.org/article/6bcff2133149453ca150abb910cd16f2

Zobrazit plný text záznamu

Akademický článek

Genetic control of differential acetylation in diabetic rats.

Autor: Pamela J Kaisaki, Georg W Otto, Joanna F McGouran, Amine Toubal, Karène Argoud, Helen Waller-Evans, Clare Finlay, Sophie Caldérari, Marie-Thérèse Bihoreau, Benedikt M Kessler, Dominique Gauguier, Richard Mott

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94555 (2014)

Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation in gene expression and DNA sequence is unclear. We address this question in the Goto-Kakiz

Externí odkaz: https://doaj.org/article/df135f88f9f649eaad9b62bf58e4c475

Zobrazit plný text záznamu

Akademický článek

A modified RNA-Seq approach for whole genome sequencing of RNA viruses from faecal and blood samples.

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66129 (2013)

To date, very large scale sequencing of many clinically important RNA viruses has been complicated by their high population molecular variation, which creates challenges for polymerase chain reaction and sequencing primer design. Many RNA viruses are

Externí odkaz: https://doaj.org/article/a2407922c58b47e5ad9a468cfd3fdb1b

Zobrazit plný text záznamu

Akademický článek

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Autor: Robert H Wallis, Stephan C Collins, Pamela J Kaisaki, Karène Argoud, Steven P Wilder, Karin J Wallace, Massimiliano Ria, Alain Ktorza, Patrik Rorsman, Marie-Thérèse Bihoreau, Dominique Gauguier

Publikováno v: PLoS ONE, Vol 3, Iss 8, p e2962 (2008)

BACKGROUND:Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS:We have generated extensive physiological, genetic and g

Externí odkaz: https://doaj.org/article/1872e1fd71ef4dab85caf745480c854a

Zobrazit plný text záznamu

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

Autor: Stephan C. Collins, Dominique Gauguier, Marie-Thérèse Bihoreau, Robert H. Wallis, Richard Mott, Sophie Calderari, Jean-Baptiste Cazier, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Karène Argoud, Georg W. Otto, Pamela J. Kaisaki

Publikováno v: G3
G3, 2016, 6 (11), pp.3671-3683. ⟨10.1534/g3.116.033274⟩
G3, Genetics Society of America, 2016, 6 (11), pp.3671-3683. ⟨10.1534/g3.116.033274⟩
G3: Genes, Genomes, Genetics, Vol 6, Iss 11, Pp 3671-3683 (2016)
G3, Genetics Society of America, 2016, 6 (11), pp.3671-3683. 〈10.1534/g3.116.033274〉
G3: Genes|Genomes|Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeafc5e60b0592260cc6a2a9de71ea6
https://hal.sorbonne-universite.fr/hal-01425993

Zobrazit plný text záznamu

Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase

Autor: Karène Argoud, Yulan Wang, Dominique Gauguier, Steve Chappell Mitchell, Benjamin J. Blaise, Timothy M. D. Ebbels, John C. Lindon, Pamela J. Kaisaki, Jean-Baptiste Cazier, Kirill Veselkov, Jeremy K. Nicholson, Elaine Holmes, Tsz M. Tsang, James Scott, Marie-Thérèse Bihoreau, Marc-Emmanuel Dumas

Publikováno v: Journal of Proteome Research
Journal of Proteome Research, 2012, 11 (2), pp.631-642. ⟨10.1021/pr200566t⟩
Journal of Proteome Research, American Chemical Society, 2012, 11 (2), pp.631-642. ⟨10.1021/pr200566t⟩
Journal of Proteome Research; Vol 11

With successes of genome-wide association studies, molecular phenotyping systems are developed to identify genetically determined disease-associated biomarkers. Genetic studies of the human metabolome are emerging but exclusively apply targeted appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe41f4eb73a1fdc4eb6cb5af764e5da1

Zobrazit plný text záznamu

Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes

Autor: M Ria, J P Grew, Mark I. McCarthy, Karène Argoud, Joshua C. Randall, Stephan C. Collins, Jennifer M. Taylor, Dominique Gauguier, Amy Barrett, Cecilia M. Lindgren, Helen Lockstone, Blanca M. Herrera, Mary E. Travers, Carlos García-Gutiérrez Fernández, Pamela J. Kaisaki, Anna L. Gloyn

Publikováno v: Diabetologia

Aims/hypothesis MicroRNAs regulate a broad range of biological mechanisms. To investigate the relationship between microRNA expression and type 2 diabetes, we compared global microRNA expression in insulin target tissues from three inbred rat strains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b3ab622319fe0fdfb1b7dc7020c9d0
https://doi.org/10.1007/s00125-010-1667-2

Zobrazit plný text záznamu

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models

Autor: Ulla G. Sidelmann, Lisa D'Amato, Robert H. Wallis, Christine Blancher, Jane F. Fearnside, Richard H. Barton, Hector C. Keun, Karène Argoud, Marc-Emmanuel Dumas, Dominique Gauguier, Jeremy K. Nicholson, Steven P. Wilder, Dorrit Baunsgaard, James Scott, Marie-Thérèse Bihoreau

Publikováno v: Nature Genetics. 39:666-672

Characterizing the relationships between genomic and phenotypic variation is essential to understanding disease etiology. Information-dense data sets derived from pathophysiological1, proteomic2,3 and transcriptomic4 profiling have been applied to ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84eb80740df057a85e7f26e3fb16c399
https://doi.org/10.1038/ng2026

Zobrazit plný text záznamu

Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto–Kakizaki rats

Autor: M. T. Bihoreau, Alain Ktorza, Dominique Gauguier, Peng Y. Woon, Steven P. Wilder, Karène Argoud, Robert H. Wallis, F. Ouali, M. A. McAteer

Publikováno v: Diabetologia. 49:2679-2688

AIMS/HYPOTHESIS: Dyslipidaemia is a main component of the insulin resistance syndrome. The inbred Goto-Kakizaki (GK) rat is a model of spontaneous type 2 diabetes and insulin resistance, which has been used to identify diabetes-related susceptibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef18a289ed639ada5bcc277a598526db
https://doi.org/10.1007/s00125-006-0396-z

Zobrazit plný text záznamu

Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats

Autor: Marie-Thérèse Bihoreau, Karin J. Wallace, Steven P. Wilder, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Dominique Gauguier, Pamela J. Kaisaki

Publikováno v: Mammalian Genome. 17:538-547

Genetic studies in experimental crosses derived from the inbred Goto-Kakizaki (GK) rat model of spontaneous diabetes mellitus have identified quantitative trait loci (QTL) for diabetes phenotypes in a large region of rat Chromosome (RNO) 1. To test t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d648fa334282c13a20b7046ccd142a61
https://doi.org/10.1007/s00335-005-0168-y

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání