Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Kar, Muthumani"'
Autor:
Christopher Chung, Pratiba Irudayaraj, Emran Lallow, Ziyang Xu, Young K. Park, Sagar B. Kudchodkar, Luis J. Montaner, Alagarsamy Srinivasan, Kar Muthumani
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
In the past 25 years, the world has witnessed outbreaks of illnesses in humans from three different coronaviruses. Both the SARS-CoV outbreak of 2003 and the MERS-CoV outbreak of 2013 resulted in overall low fatalities in part due to inefficient huma
Externí odkaz:
https://doaj.org/article/d5ba64b04cea4f768a76a71359d2a310
Autor:
Woo Joo Kim, Christine C. Roberts, Joon Young Song, Jin Gu Yoon, Hye Seong, Hak-Jun Hyun, Hyojin Lee, Areum Gil, Yeeun Oh, Ji-eun Park, Bohyun Jeon, Ji-Eun Lee, Sang Kyu Choi, Sun Kyung Yoon, Sunhee Lee, Byoungguk Kim, Deborah Kane, Susan Spruill, Sagar B. Kudchodkar, Kar Muthumani, Young K. Park, Ijoo Kwon, Moonsup Jeong, Joel N. Maslow
Publikováno v:
International Journal of Infectious Diseases, Vol 128, Iss , Pp 112-120 (2023)
Objectives: The CoV2-001 phase I randomized trial evaluated the safety and immunogenicity of the GLS-5310 bi-cistronic DNA vaccine through 48 weeks of follow-up. Design: A total of 45 vaccine-naïve participants were recruited between December 31, 20
Externí odkaz:
https://doaj.org/article/da9fa872d6a64c41a782f9bb44514858
Autor:
Sagar B Kudchodkar, Paolo Fagone, Omkar U Kawalekar, Moonsup Jeong, Christine C Roberts, Hyojin Lee, Youngran Cho, Areum Gil, Yeeun Oh, Bohyun Jeon, Gee Ho Park, Young K Park, Ferdinando Nicoletti, Joel N Maslow, Kar Muthumani
Publikováno v:
Translational Medicine Communications, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract In the present study, the effect(s) of the immunomodulatory drug GLS-1027 on various cell types involved in inflammation were investigated. GLS-1027 reduced LPS-stimulated secretion of pro-inflammatory cytokines by macrophage or monocytic ce
Externí odkaz:
https://doaj.org/article/405ed5a8ca7941f389f90989ca81b381
Autor:
Pratima Saini, Opeyemi S. Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M. Parent, Kai Ying Hong, Jane Koshy, Abhijeet J. Kulkarni, Netanel F. Zilberstein, Robert A. Balk, James N. Moy, Leila B. Giron, Russell P. Tracy, Ali Keshavarzian, Kar Muthumani, Alan Landay, David B. Weiner, Mohamed Abdel-Mohsen
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the immunological profiles of natural killer (NK) cells. However, whether NK antiviral functions are impaired during severe coronavirus disease 2019 (COVID-19) and
Externí odkaz:
https://doaj.org/article/9b30c013c37148c591071bf5b0975101
Autor:
Hyeree Choi, Sagar B. Kudchodkar, Ziyang Xu, Michelle Ho, Peng Xiao, Stephanie Ramos, Laurent Humeau, David B. Weiner, Kar Muthumani
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
Nipah virus (NiV) is a re-emerging pathogen that causes severe disease in animals and humans. Current treatment measures for NiV infection are insufficient, and there is no approved vaccine against NiV for either humans or animals. Nipah virus is lis
Externí odkaz:
https://doaj.org/article/ce87848b3a22426bacc93e3b346d441d
Autor:
Christopher Chung, Sagar B. Kudchodkar, Curtis N. Chung, Young K. Park, Ziyang Xu, Norbert Pardi, Mohamed Abdel-Mohsen, Kar Muthumani
Publikováno v:
Antibodies, Vol 12, Iss 3, p 46 (2023)
Harnessing the immune system to combat disease has revolutionized medical treatment. Monoclonal antibodies (mAbs), in particular, have emerged as important immunotherapeutic agents with clinical relevance in treating a wide range of diseases, includi
Externí odkaz:
https://doaj.org/article/34b15e90a84d436290d76e1435b6127e
Autor:
Kar Muthumani, Ziyang Xu, Moonsup Jeong, Joel N. Maslow, Vaniambadi S. Kalyanaraman, Alagarsamy Srinivasan
Publikováno v:
Translational Medicine Communications, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract The causative agent of the ongoing pandemic in the world is SARS-CoV-2. The research on SARS-CoV-2 has progressed with lightning speed on various fronts, including clinical research and treatment, virology, epidemiology, drug development, an
Externí odkaz:
https://doaj.org/article/964eeb21c0bc4eb49cbae86f05539c9d
Autor:
Laura K. Aisenberg, Kimberly E. Rousseau, Katherine Cascino, Guido Massaccesi, William H. Aisenberg, Wensheng Luo, Kar Muthumani, David B. Weiner, Stephen S. Whitehead, Michael A. Chattergoon, Anna P. Durbin, Andrea L. Cox
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
The Aedes aegypti mosquito transmits both dengue virus (DENV) and Zika virus (ZIKV) . Individuals in endemic areas are at risk for infection with both viruses, as well as for repeated DENV infection. In the presence of anti-DENV antibodies, outcomes
Externí odkaz:
https://doaj.org/article/b518d8789686457aafe5b023c2ac3a9d
Autor:
Joel N. Maslow, Ijoo Kwon, Sagar B. Kudchodkar, Deborah Kane, Amha Tadesse, Hyojin Lee, Young K. Park, Kar Muthumani, Christine C. Roberts
Publikováno v:
Vaccines, Vol 11, Iss 6, p 1016 (2023)
We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received
Externí odkaz:
https://doaj.org/article/db4abbdac7ec4dfca8a719728b7add0e
Autor:
Rajasekharan Somasundaram, Thomas Connelly, Robin Choi, Hyeree Choi, Anastasia Samarkina, Ling Li, Elizabeth Gregorio, Yeqing Chen, Rohit Thakur, Mohamed Abdel-Mohsen, Marilda Beqiri, Meaghan Kiernan, Michela Perego, Fang Wang, Min Xiao, Patricia Brafford, Xue Yang, Xiaowei Xu, Anthony Secreto, Gwenn Danet-Desnoyers, Daniel Traum, Klaus H. Kaestner, Alexander C. Huang, Denitsa Hristova, Joshua Wang, Mizuho Fukunaga-Kalabis, Clemens Krepler, Fang Ping-Chen, Xiangyang Zhou, Alexis Gutierrez, Vito W. Rebecca, Prashanthi Vonteddu, Farokh Dotiwala, Shashi Bala, Sonali Majumdar, Harsh Dweep, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Jorge Reyes-Arbujas, Kenisha Santiago, Tran Nguyen, Johannes Griss, Frederick Keeney, James Hayden, Brian J. Gavin, David Weiner, Luis J. Montaner, Qin Liu, Lukas Peiffer, Jürgen Becker, Elizabeth M. Burton, Michael A. Davies, Michael T. Tetzlaff, Kar Muthumani, Jennifer A. Wargo, Dmitry Gabrilovich, Meenhard Herlyn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC
Externí odkaz:
https://doaj.org/article/1dbc726f512b49e4900c71d53883f0cc