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Dissecting Regulators of Aging and Age-Related Macular Degeneration in the Retinal Pigment Epithelium.

Autor: Karunadharma PP; Department of Ophthalmology and Visual Neurosciences, University of Minnesota Twin Cities, MN 55455, USA.; Graduate Program in Biochemistry, Molecular Biology, And Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA., Kapphahn RJ; Department of Ophthalmology and Visual Neurosciences, University of Minnesota Twin Cities, MN 55455, USA., Stahl MR; Department of Ophthalmology and Visual Neurosciences, University of Minnesota Twin Cities, MN 55455, USA., Olsen TW; Department of Ophthalmology and Visual Neurosciences, University of Minnesota Twin Cities, MN 55455, USA., Ferrington DA; Department of Ophthalmology and Visual Neurosciences, University of Minnesota Twin Cities, MN 55455, USA.; Graduate Program in Biochemistry, Molecular Biology, And Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.

Publikováno v: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Nov 16; Vol. 2022, pp. 6009787. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022).

Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction.

Autor: Sterling JK; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Medical Scientist Training Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Baumann B; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Medical Scientist Training Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Foshe S; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Voigt A; Institute for Vision Research, The University of Iowa, Iowa City, IA 52242, USA; Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Guttha S; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Alnemri A; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., McCright SJ; Medical Scientist Training Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Li M; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Zauhar RJ; Department of Chemistry & Biochemistry, University of the Sciences, Philadelphia, PA 19104, USA., Montezuma SR; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Kapphahn RJ; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Chavali VRM; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Hill DA; Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Ferrington DA; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Stambolian D; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Mullins RF; Institute for Vision Research, The University of Iowa, Iowa City, IA 52242, USA; Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Merrick D; Department of Medicine, Division of Endocrinology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Dunaief JL; FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: jdunaief@pennmedicine.upenn.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Jun 14; Vol. 39 (11), pp. 110942.

Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration.

Autor: Ebeling MC; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Geng Z; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA., Stahl MR; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Kapphahn RJ; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Roehrich H; Histology Core for Vision Research, University of Minnesota, Minneapolis, MN 55455, USA., Montezuma SR; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA., Ferrington DA; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA.; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA., Dutton JR; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Jan 04; Vol. 15 (1). Date of Electronic Publication: 2022 Jan 04.