Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kapongo Lumamba"'
Autor:
Robert Krause, Paul Ogongo, Liku Tezera, Mohammed Ahmed, Ian Mbano, Mark Chambers, Abigail Ngoepe, Magalli Magnoumba, Daniel Muema, Farina Karim, Khadija Khan, Kapongo Lumamba, Kievershen Nargan, Rajhmun Madansein, Adrie Steyn, Alex K. Shalek, Paul Elkington, Al Leslie
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of patients with TB and found they are decreased in the blood and increas
Externí odkaz:
https://doaj.org/article/23c37a25fe0246aca37d4431b56b7432
Autor:
Kievershen Nargan, Joel N. Glasgow, Sajid Nadeem, Threnesan Naidoo, Gordon Wells, Robert L. Hunter, Anneka Hutton, Kapongo Lumamba, Mpumelelo Msimang, Paul V. Benson, Adrie J.C. Steyn
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105196- (2024)
Summary: Background: The ability to detect evidence of Mycobacterium tuberculosis (Mtb) infection within human tissues is critical to the study of Mtb physiology, tropism, and spatial distribution within TB lesions. The capacity of the widely-used Zi
Externí odkaz:
https://doaj.org/article/c2aa012d92044891b73dc83da8e15091
Autor:
Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kievershen Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by
Externí odkaz:
https://doaj.org/article/4e4ad46f3eb246c2ab7a16acbf265d77
Autor:
Gordon Wells, Joel N Glasgow, Kievershen Nargan, Kapongo Lumamba, Rajhmun Madansein, Kameel Maharaj, Leon Y Perumal, Malcolm Matthew, Robert L Hunter, Hayden Pacl, Jacelyn E Peabody Lever, Denise D Stanford, Satinder P Singh, Prachi Bajpai, Upender Manne, Paul V Benson, Steven M Rowe, Stephan le Roux, Alex Sigal, Muofhe Tshibalanganda, Carlyn Wells, Anton du Plessis, Mpumelelo Msimang, Threnesan Naidoo, Adrie J C Steyn
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 11, Pp 1-19 (2022)
Abstract Our current understanding of the spectrum of TB and COVID‐19 lesions in the human lung is limited by a reliance on low‐resolution imaging platforms that cannot provide accurate 3D representations of lesion types within the context of the
Externí odkaz:
https://doaj.org/article/9de06189f2644003be25524c2336f9a7
Autor:
Gordon Wells, Kievershen Nargan, Kameel Maharaj, Joel N. Glasgow, Llelani Coetzer, Robert L. Hunter, Adrie J. C. Steyn, Stephan G. le Roux, Rajhmun Madansein, Threnesan Naidoo, Kapongo Lumamba, Anton du Plessis
Publikováno v:
Am J Respir Crit Care Med
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
Rationale: Our current understanding of tuberculosis (TB) pathophysiology is limited by a reliance on animal models, the paucity of human TB lung tissue, and traditional histopathological analysis, a destructive two-dimensional approach that provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56f939672469fff60c2066057b4be14
https://doi.org/10.1164/rccm.202101-0032oc
https://doi.org/10.1164/rccm.202101-0032oc
Autor:
Gordon Wells, Joel N Glasgow, Kievershen Nargan, Kapongo Lumamba, Rajhmun Madansein, Kameel Maharaj, Leon Y Perumal, Malcolm Matthew, Robert L Hunter, Hayden Pacl, Jacelyn E Peabody Lever, Denise D Stanford, Satinder P Singh, Prachi Bajpai, Upender Manne, Paul V Benson, Steven M Rowe, Stephan le Roux, Alex Sigal, Muofhe Tshibalanganda, Carlyn Wells, Anton du Plessis, Mpumelelo Msimang, Threnesan Naidoo, Adrie J C Steyn
Publikováno v:
EMBO Molecular Medicine. 14
Our current understanding of the spectrum of TB and COVID-19 lesions in the human lung is limited by a reliance on low-resolution imaging platforms that cannot provide accurate 3D representations of lesion types within the context of the whole lung.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b50999085ec4c9a8ecbab1a1dc1eba
https://doi.org/10.15252/emmm.202216283
https://doi.org/10.15252/emmm.202216283
Autor:
Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kierveshan Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by NAD+ sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2cdf01b8274064bd279cb8daf99a352
https://doi.org/10.1101/2022.09.11.507472
https://doi.org/10.1101/2022.09.11.507472
Autor:
Threnesan Naidoo, Kameel Maharaj, Kievershen Nargan, Pratista Ramdial, Llelani Coetzer, Anton du Plessis, Rajhmun Madansein, Joel N. Glasgow, Robert L. Hunter, Kapongo Lumamba, Stephan G. le Roux, Gordon Wells, Adrie J. C. Steyn
Our current understanding of the pathophysiology of human pulmonary TB is limited by the paucity of human TB lung tissue for study and reliance on 2D analytical methods. Here, to overcome the limitations of conventional 2D histopathology, we used hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350a82779b305b36e2df1dd42bc315fb
https://doi.org/10.1101/2020.06.14.149898
https://doi.org/10.1101/2020.06.14.149898