Intergenerational effects of dietary restriction on insulin/IGF signaling and reproductive development

Autor: Kaplan Rew, Ryan Guzman, Jane Albert Hubbard E, Colin S. Maxwell, James M. Jordan, Ryan Baugh L, Jonathan D. Hibshman, Elizabeth Anne Bowman, Amy K. Webster, Abigail Leinroth

The roundwormC. eleganstransiently arrests larval development to survive extended starvation (1), but such early-life starvation reduces reproductive success (2, 3). Maternal dietary restriction (DR) buffers progeny from starvation, increasing reprod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc8134995ed2cfdf091ce0bcc8a91db
https://doi.org/10.1101/342956

Population Selection and Sequencing of Caenorhabditis elegans Wild Isolates Identifies a Region on Chromosome III Affecting Starvation Resistance.

Autor: Webster AK; Department of Biology, Duke University, Durham, NC.; University Program in Genetics and Genomics, Duke University, Durham, NC, and., Hung A; Department of Biology, Duke University, Durham, NC., Moore BT; Department of Biology, Duke University, Durham, NC., Guzman R; Department of Biology, Duke University, Durham, NC., Jordan JM; Department of Biology, Duke University, Durham, NC., Kaplan REW; Department of Biology, Duke University, Durham, NC.; University Program in Genetics and Genomics, Duke University, Durham, NC, and., Hibshman JD; Department of Biology, Duke University, Durham, NC.; University Program in Genetics and Genomics, Duke University, Durham, NC, and., Tanny RE; Department of Molecular Biosciences, Northwestern University, Evanston, IL., Cook DE; Department of Molecular Biosciences, Northwestern University, Evanston, IL., Andersen E; Department of Molecular Biosciences, Northwestern University, Evanston, IL., Baugh LR; Department of Biology, Duke University, Durham, NC ryan.baugh@duke.edu.

Publikováno v: G3 (Bethesda, Md.) [G3 (Bethesda)] 2019 Oct 07; Vol. 9 (10), pp. 3477-3488. Date of Electronic Publication: 2019 Oct 07.

Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals.

Autor: Shin H; Institute of Biosciences and Technology, Texas A&M Health Science Center, Texas A&M University, Houston, TX, United States of America., Braendle C; Université Côte d'Azur, CNRS, Inserm, IBV, Nice, France., Monahan KB; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America., Kaplan REW; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America., Zand TP; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America.; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, United States of America., Mote FS; Institute of Biosciences and Technology, Texas A&M Health Science Center, Texas A&M University, Houston, TX, United States of America., Peters EC; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America., Reiner DJ; Institute of Biosciences and Technology, Texas A&M Health Science Center, Texas A&M University, Houston, TX, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America.; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2019 May 14; Vol. 15 (5), pp. e1008056. Date of Electronic Publication: 2019 May 14 (Print Publication: 2019).

Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.

Autor: Burton NO; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. nob20@cam.ac.uk.; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK. nob20@cam.ac.uk., Dwivedi VK; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Burkhart KB; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Kaplan REW; Department of Biology, Duke University, Durham, NC, 27708, USA., Baugh LR; Department of Biology, Duke University, Durham, NC, 27708, USA., Horvitz HR; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. horvitz@mit.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Dec 04; Vol. 9 (1), pp. 5152. Date of Electronic Publication: 2018 Dec 04.

Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning.

Autor: Shin H; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA., Kaplan REW; Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA., Duong T; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA., Fakieh R; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA., Reiner DJ; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA; Department of Medical Physiology, College of Medicine, Texas A&M University, College Station, TX 77843, USA; Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: dreiner@ibt.tamhsc.edu.

Publikováno v: Cell reports [Cell Rep] 2018 Sep 04; Vol. 24 (10), pp. 2669-2681.e5.