Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma

Autor: Kapjun Kim, Xiaolin Zi, Peter McQueen, Carol Lin, Yi Guo, Ramez N. Eskander, Bang H. Hoang, Samia Ghaffar, Alexander B. Christ, Tao Ji

Publikováno v: Molecular Cancer
Ji, Tao; Guo, Yi; Kim, Kapjun; McQueen, Peter; Ghaffar, Samia; Christ, Alexander; et al.(2015). Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. Molecular Cancer, 14(1). doi: 10.1186/s12943-015-0359-4. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/0dk598gj

Background Neuropilin 2 (NRP2) isa multi-functional co-receptor to many receptors, including VEGF receptor, c-Met and others. NRP2 has recently been implicated in tumor angiogenesis, growth, and metastasis of many other cancers. However, its role in

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https://pubmed.ncbi.nlm.nih.gov/25890345