Zobrazeno 1 - 10
of 436
pro vyhledávání: '"Kapil N, Bhalla"'
Autor:
Christopher P. Mill, Warren C. Fiskus, Courtney D. DiNardo, Patrick Reville, John A. Davis, Christine E. Birdwell, Kaberi Das, Hanxi Hou, Koichi Takahashi, Lauren Flores, Xinjia Ruan, Xiaoping Su, Sanam Loghavi, Joseph D. Khoury, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Germline, mono-allelic mutations in RUNX1 cause familial platelet disorder (RUNX1-FPD) that evolves into myeloid malignancy (FPD-MM): MDS or AML. FPD-MM commonly harbors co-mutations in the second RUNX1 allele and/or other epigenetic regulat
Externí odkaz:
https://doaj.org/article/b9424549a1ed49b58740fad27c6be69c
Autor:
Warren Fiskus, Christopher P. Mill, Christine Birdwell, John A. Davis, Kaberi Das, Steffen Boettcher, Tapan M. Kadia, Courtney D. DiNardo, Koichi Takahashi, Sanam Loghavi, Michael J. Soth, Tim Heffernan, Gerard M. McGeehan, Xinjia Ruan, Xiaoping Su, Christopher R. Vakoc, Naval Daver, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Monotherapy with Menin inhibitor (MI), e.g., SNDX-5613, induces clinical remissions in patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either fail to respond or eventually relapse. Utilizing single-cell RN
Externí odkaz:
https://doaj.org/article/ac5251edf70f45ea8914536e1354701b
Autor:
Warren Fiskus, Steffen Boettcher, Naval Daver, Christopher P. Mill, Koji Sasaki, Christine E. Birdwell, John A. Davis, Koichi Takahashi, Tapan M. Kadia, Courtney D. DiNardo, Qi Jin, Yuan Qi, Xiaoping Su, Gerard M. McGeehan, Joseph D. Khoury, Benjamin L. Ebert, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Treatment with Menin inhibitor (MI) disrupts the interaction between Menin and MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of survival of AML harboring MLL1 re-arrangement (r) and FP, or expressin
Externí odkaz:
https://doaj.org/article/bae406bbb1b54e0e95befd702e938368
Autor:
Warren Fiskus, Taghi Manshouri, Christine Birdwell, Christopher P. Mill, Lucia Masarova, Prithviraj Bose, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Gautam Borthakur, Joseph D. Khoury, Srdan Verstovsek, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 1, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/b94caea015564a40b34fc469839116e9
Autor:
Warren Fiskus, Christopher P. Mill, Behnam Nabet, Dimuthu Perera, Christine Birdwell, Taghi Manshouri, Bernardo Lara, Tapan M. Kadia, Courtney DiNardo, Koichi Takahashi, Naval Daver, Prithviraj Bose, Lucia Masarova, Naveen Pemmaraju, Steven Kornblau, Gautam Borthakur, Guillermo Montalban-Bravo, Guillermo Garcia Manero, Sunil Sharma, Matthew Stubbs, Xiaoping Su, Michael R. Green, Cristian Coarfa, Srdan Verstovsek, Joseph D. Khoury, Christopher R. Vakoc, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 5, Pp 1-16 (2021)
Abstract There is an unmet need to overcome nongenetic therapy-resistance to improve outcomes in AML, especially post-myeloproliferative neoplasm (MPN) secondary (s) AML. Studies presented describe effects of genetic knockout, degradation or small mo
Externí odkaz:
https://doaj.org/article/45520ecba0484c299486fcf8bcac108d
Autor:
Feng Wang, Kiyomi Morita, Courtney D. DiNardo, Ken Furudate, Tomoyuki Tanaka, Yuanqing Yan, Keyur P. Patel, Kyle J. MacBeth, Bin Wu, Guowen Liu, Mark Frattini, Jairo A. Matthews, Latasha D. Little, Curtis Gumbs, Xingzhi Song, Jianhua Zhang, Erika J. Thompson, Tapan M. Kadia, Guillermo Garcia-Manero, Elias Jabbour, Farhad Ravandi, Kapil N. Bhalla, Marina Konopleva, Hagop M. Kantarjian, P. Andrew Futreal, Koichi Takahashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The regulation of resistance to IDH inhibitors in acute myeloid leukaemia is not completely understood. Here the authors reveal with integrative multi-omics analyses that stemness features are major drivers of primary resistance, while high-risk muta
Externí odkaz:
https://doaj.org/article/af530f137f2d430f8c1dd47dd38789db
Autor:
Christine Birdwell, Warren Fiskus, Tapan M. Kadia, Courtney D. DiNardo, Christopher P. Mill, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 3, Pp 1-14 (2021)
Abstract Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic zinc-finger transcription factor whose overexpression contribute
Externí odkaz:
https://doaj.org/article/4dda276aeb51439586c98eeef4c28c0a
Autor:
Siba El Hussein, L. Jeffrey Medeiros, Kirill A. Lyapichev, Hong Fang, Fatima Zahra Jelloul, Warren Fiskus, Jiansong Chen, Peng Wei, Ellen Schlette, Jie Xu, Shaoying Li, Rashmi Kanagal-Shamanna, Hong Yang, Zhenya Tang, Beenu Thakral, Sanam Loghavi, Nitin Jain, Philip A. Thompson, Alessandra Ferrajoli, William G. Wierda, Elias Jabbour, Keyur P. Patel, Bouthaina S. Dabaja, Kapil N. Bhalla, Joseph D. Khoury
Publikováno v:
Pathology. 55:514-524
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::399a979eb7c2fc1b1ebba02db4cd3898
https://doi.org/10.1016/j.pathol.2022.12.354
https://doi.org/10.1016/j.pathol.2022.12.354
Autor:
Tapan M. Kadia, Patrick K. Reville, Xuemei Wang, Caitlin R. Rausch, Gautam Borthakur, Naveen Pemmaraju, Naval G. Daver, Courtney D. DiNardo, Koji Sasaki, Ghayas C. Issa, Maro Ohanian, Guillermo Montalban-Bravo, Nicholas J. Short, Nitin Jain, Alessandra Ferrajoli, Kapil N. Bhalla, Elias Jabbour, Koichi Takahashi, Rashmi Malla, Kelly Quagliato, Rashmi Kanagal-Shamanna, Uday R. Popat, Michael Andreeff, Guillermo Garcia-Manero, Marina Y. Konopleva, Farhad Ravandi, Hagop M. Kantarjian
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(33)
PURPOSE The combination of venetoclax and 5-azacitidine (5-AZA) for older or unfit patients with acute myeloid leukemia (AML) improves remission rates and survival compared with 5-AZA alone. We hypothesized that the addition of venetoclax to cladribi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04f470593a5d93126e85fa9b3f05a41
https://pubmed.ncbi.nlm.nih.gov/35704787
https://pubmed.ncbi.nlm.nih.gov/35704787
Autor:
Prajwal Boddu, Hagop M. Kantarjian, Guillermo Garcia-Manero, Farhad Ravandi, Srdan Verstovsek, Elias Jabbour, Gautam Borthakur, Marina Konopleva, Kapil N. Bhalla, Naval Daver, Courtney D. DiNardo, Christopher B. Benton, Koichi Takahashi, Zeev Estrov, Sherry R. Pierce, Michael Andreeff, Jorge E. Cortes, Tapan M. Kadia
Publikováno v:
Blood Advances, Vol 1, Iss 17, Pp 1312-1323 (2017)
Abstract: Secondary acute myeloid leukemia (s-AML) includes therapy-related AML and AML evolving from antecedent hematological disorder (AHD). s-AML arising after treating AHD likely represents a prognostically distinct, high-risk disease category. I
Externí odkaz:
https://doaj.org/article/fb67d5abf34d43608bfe5e998d063e71