Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Kapil K, Patil"'
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Akademický článek
Chloroxylon swietenia (Roxb.) DC induces cell death and apoptosis by down‐regulating the NF‐κB pathway in MCF‐7 breast cancer cells: In vitro and in vivo investigations
Autor: Sonali S. Kamble, Jasoda Choudhari, Ramakrishna Nimma, Totakura Venkata Santosh Kumar, Kapil K. Patil, Shrikant V. Hese, Bhaskar S. Dawane, Rajesh N. Gacche
Publikováno v: Cancer Reports, Vol 5, Iss 10, Pp n/a-n/a (2022)
Abstract Background Natural products with targeted bioactivity have gained major attention in the field of cancer research owing to emerging anti‐cancer drug resistance and off target toxicities. Chloroxylon swietenia (Roxb.) DC is recognized as a
Externí odkaz: https://doaj.org/article/e2d00c2f9c2e467f83e11d7f3daef3cc
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3
Chloroxylon swietenia (Roxb.) DC induces cell death and apoptosis by down-regulating the NF-κB pathway in MCF-7 breast cancer cells: In vitro and in vivo investigations
Autor: Sonali S, Kamble, Jasoda, Choudhari, Ramakrishna, Nimma, Totakura Venkata Santosh, Kumar, Kapil K, Patil, Shrikant V, Hese, Bhaskar S, Dawane, Rajesh N, Gacche
Publikováno v: Cancer reports (Hoboken, N.J.). 5(10)
Natural products with targeted bioactivity have gained major attention in the field of cancer research owing to emerging anti-cancer drug resistance and off target toxicities. Chloroxylon swietenia (Roxb.) DC is recognized as a folklore medicinal pla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6413ac5697aa521c06ca803505f83f45
https://pubmed.ncbi.nlm.nih.gov/35274824
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4
Antidiabetic and allied biochemical roles of new chromeno-pyrano pyrimidine compounds: synthesis, in vitro and in silico analysis
Autor: Rajesh N. Gacche, Sonali S. Kamble, Bhaskar S. Dawane, Rohan J. Meshram, Kapil K. Patil, Shrikant V. Hese, Pratima P. Mogle, Rahul D. Kamble
Publikováno v: Medicinal Chemistry Research. 26:805-818
Diabetes is embracing the human population in logarithmic fashion both in developed as well as developing countries. Aldose reductase is one of the important enzymes of polyol pathway of sugar metabolism in humans. Aldose reductase inhibition has bee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::996d7eeb01ff2f802143d7b76febc213
https://doi.org/10.1007/s00044-017-1794-0
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5
Role of dietary flavonoids in amelioration of sugar induced cataractogenesis
Autor: Rohan J. Meshram, Kapil K. Patil, Rajesh N. Gacche, N.A. Dhole
Publikováno v: Archives of Biochemistry and Biophysics. 593:1-11
Sugar induced cataractogenesis and visual impairment is more prominent ophthalmic problem in humans suffering from diabetes. Flavonoids have been identified as one of the therapeutically important class of phytochemicals possessing myriad of biologic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578ed29a58b647e24e7c0ea13c86507a
https://doi.org/10.1016/j.abb.2016.01.015
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6
Dietary flavonoids inhibit the glycation of lens proteins: implications in the management of diabetic cataract
Autor: Rajesh N. Gacche, Kapil K. Patil, Sagar H. Barage, Rohan J. Meshram
Publikováno v: 3 Biotech. 9(2)
The intervention of functional foods as complementary therapeutic approach for the amelioration of diabetes and sugar induced cataractogenesis is more appreciated over the present day chemotherapy agents owing to their nontoxic and increased bioavail
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611ad0d29e8d1af7a7026899eb57f9cc
https://pubmed.ncbi.nlm.nih.gov/30729071
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7
Development of novel pyrazolone derivatives as inhibitors of aldose reductase: An eco-friendly one-pot synthesis, experimental screening and in silico analysis
Autor: Manisha Pawar, Harshala D. Shegokar, Rajesh N. Gacche, Rohan J. Meshram, Kapil K. Patil, Bhaskar S. Dawane, Aparna Kadam
Publikováno v: Bioorganic Chemistry. 53:67-74
Aldose reductase is the key enzyme of polypol pathway leading to accumulation of sorbitol. Sorbitol does not diffuse across the cell membranes easily and therefore accumulates within the cell, causing osmotic damage which leads to retinopathy (catara
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d86ad16d9f0a05c0aa10452e0bf345
https://doi.org/10.1016/j.bioorg.2014.02.002
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8
Inhibition of glycation and aldose reductase activity using dietary flavonoids: A lens organ culture studies
Autor: Rajesh N. Gacche, Kapil K. Patil
Publikováno v: International journal of biological macromolecules. 98
On the eve of increasing incidence of diabetes mellitus and related complications, the search for novel, safe and alternatives therapeutic approaches are evolving. In the present investigation, a panel of ten dietary flavonoids such as 4'-methoxyflav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d88d1a40ab79c9074672e00e1220d4
https://pubmed.ncbi.nlm.nih.gov/28192136
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9
Effect of monohydroxylated flavonoids on glycation-induced lens opacity and protein aggregation
Autor: Rajesh N. Gacche, Kapil K. Patil, Rohan J. Meshram
Publikováno v: Journal of enzyme inhibition and medicinal chemistry. 31(sup1)
Glycation-induced cataractogenesis and visual impairment is a major ophthalmic concern of altered sugar homeostasis in humans as well as animals. Searching antiglycating agents from natural sources is widely acknowledged as it can be made bioavailabl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2b8e2b35c1d1a137f4d3dcdcba86b5
https://pubmed.ncbi.nlm.nih.gov/27149249
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