Cannabinoid receptor 2 deficiency exacerbates inflammation and neutrophil recruitment

Autor: Kapellos, TS, Taylor, L, Feuerborn, A, Valaris, S, Hussain, MT, Rainger, GE, Greaves, DR, Iqbal, AJ, Needham, G

Publikováno v: FASEB Journal. 33(5)

Cannabinoid receptor (CB)2 is an immune cell-localized GPCR that has been hypothesized to regulate the magnitude of inflammatory responses. However, there is currently no consensus as to the mechanism by which CB2 mediates its anti-inflammatory effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::226f7ba0d8e60ba9204e04076fb352fc
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Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD.

Autor: Sui J; Division of Pulmonary, Allergy and Critical Care Medicine.; Department of Cellular and Molecular Pathology, and., Xiao H; Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Mbaekwe U; Division of Pulmonary, Allergy and Critical Care Medicine.; Department of Cellular and Molecular Pathology, and., Ting NC; Division of Pulmonary, Allergy and Critical Care Medicine., Murday K; Division of Pulmonary, Allergy and Critical Care Medicine., Hu Q; Division of Pulmonary, Allergy and Critical Care Medicine., Gregory AD; Division of Pulmonary, Allergy and Critical Care Medicine., Kapellos TS; Institute of Lung Health and Immunity, Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, University Hospital, Ludwig Maximilians University (LMU) of Munich, Munich, Germany., Yildirim AÖ; Institute of Lung Health and Immunity, Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, University Hospital, Ludwig Maximilians University (LMU) of Munich, Munich, Germany., Königshoff M; Division of Pulmonary, Allergy and Critical Care Medicine.; Geriatric Research Education and Clinical Center (GRECC) at the VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA., Zhang Y; Division of Pulmonary, Allergy and Critical Care Medicine., Sciurba F; Division of Pulmonary, Allergy and Critical Care Medicine., Das J; Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Kliment CR; Division of Pulmonary, Allergy and Critical Care Medicine.; Department of Cellular and Molecular Pathology, and.

Publikováno v: JCI insight [JCI Insight] 2024 Nov 08; Vol. 9 (21). Date of Electronic Publication: 2024 Nov 08.

Mass spectrometry-based autoimmune profiling reveals predictive autoantigens in idiopathic pulmonary fibrosis.

Autor: Leuschner G; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.; Department of Internal Medicine V, Ludwig-Maximilian University Munich, CPC-M bioArchive, Munich, Asklepios Clinics, Gauting, Germany., Semenova A; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Mayr CH; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Kapellos TS; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Ansari M; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Seeliger B; Department of Pneumology, Hannover Medical School, Member of the German Center for Lung Research (DZL), Hannover, Germany., Frankenberger M; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.; Department of Internal Medicine V, Ludwig-Maximilian University Munich, CPC-M bioArchive, Munich, Asklepios Clinics, Gauting, Germany., Kneidinger N; Department of Internal Medicine V, Ludwig-Maximilian University Munich, CPC-M bioArchive, Munich, Asklepios Clinics, Gauting, Germany., Hatz RA; Center for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich (LMU), Munich, and Asklepios Medical Center, Member of the German Center for Lung Research (DZL), Gauting, Germany., Hilgendorff A; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.; Center for Comprehensive Developmental Care (CDeCLMU), Hospital of the Ludwig-Maximilians University (LMU), Member of the German Center for Lung Research (DZL), CPC-M bioArchive, Munich, Germany., Prasse A; Department of Pneumology, Hannover Medical School, Member of the German Center for Lung Research (DZL), Hannover, Germany., Behr J; Department of Internal Medicine V, Ludwig-Maximilian University Munich, CPC-M bioArchive, Munich, Asklepios Clinics, Gauting, Germany., Mann M; Max Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Martinsried, Germany., Schiller HB; Institute of Lung Health and Immunity, Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilians University, Munich, Germany.

Publikováno v: IScience [iScience] 2023 Oct 27; Vol. 26 (11), pp. 108345. Date of Electronic Publication: 2023 Oct 27 (Print Publication: 2023).

Fumarate hydratase: a new checkpoint of metabolic regulation in inflammatory macrophages.

Autor: Jeridi A; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Munich, Munich, Germany., Kapellos TS; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Munich, Munich, Germany., Yildirim AÖ; Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Munich, Munich, Germany. alioender.yildirim@helmholtz-munich.de.; Institute of Experimental Pneumology, University Hospital, Ludwig-Maximilians University, München, Germany. alioender.yildirim@helmholtz-munich.de.

Publikováno v: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2023 Sep 04; Vol. 8 (1), pp. 332. Date of Electronic Publication: 2023 Sep 04.

An integrated cell atlas of the lung in health and disease.

Autor: Sikkema L; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Ramírez-Suástegui C; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Strobl DC; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Institute of Clinical Chemistry and Pathobiochemistry, TUM School of Medicine, Technical University of Munich, Munich, Germany., Gillett TE; Experimental Pulmonary and Inflammatory Research, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Zappia L; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Department of Mathematics, Technical University of Munich, Garching, Germany., Madissoon E; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Markov NS; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Zaragosi LE; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur and Centre National de la Recherche Scientifique, Valbonne, France., Ji Y; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Ansari M; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany., Arguel MJ; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur and Centre National de la Recherche Scientifique, Valbonne, France., Apperloo L; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Banchero M; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bécavin C; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur and Centre National de la Recherche Scientifique, Valbonne, France., Berg M; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Chichelnitskiy E; Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany., Chung MI; Translational Genomics Research Institute, Phoenix, AZ, USA., Collin A; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur and Centre National de la Recherche Scientifique, Valbonne, France.; 3IA Côte d'Azur, Nice, France., Gay ACA; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Gote-Schniering J; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany., Hooshiar Kashani B; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany., Inecik K; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Jain M; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kapellos TS; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany.; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Kole TM; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Leroy S; Pulmonology Department, Fédération Hospitalo-Universitaire OncoAge, Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Nice, France., Mayr CH; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany., Oliver AJ; Wellcome Sanger Institute, Hinxton, Cambridge, UK., von Papen M; Research, Development and Innovation, Comma Soft, Bonn, Germany., Peter L; Translational Genomics Research Institute, Phoenix, AZ, USA., Taylor CJ; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Walzthoeni T; Core Facility Genomics, Helmholtz Center Munich, Munich, Germany., Xu C; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Bui LT; Translational Genomics Research Institute, Phoenix, AZ, USA., De Donno C; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany., Dony L; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; TUM School of Life Sciences, Technical University of Munich, Munich, Germany.; Department of Translational Psychiatry, Max Planck Institute of Psychiatry and International Max Planck Research School for Translational Psychiatry, Munich, Germany., Faiz A; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; School of Life Sciences, Respiratory Bioinformatics and Molecular Biology, University of Technology Sydney, Sydney, Australia., Guo M; Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, US., Gutierrez AJ; Translational Genomics Research Institute, Phoenix, AZ, USA., Heumos L; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; TUM School of Life Sciences, Technical University of Munich, Munich, Germany.; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany., Huang N; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Ibarra IL; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany., Jackson ND; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA., Kadur Lakshminarasimha Murthy P; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.; Department of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL, USA., Lotfollahi M; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Tabib T; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Talavera-López C; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, Klinikum der Lüdwig-Maximilians-Universität, Munich, Germany., Travaglini KJ; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Allen Institute for Brain Science, Seattle, WA, USA., Wilbrey-Clark A; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Worlock KB; Department of Respiratory Medicine, Division of Medicine, University College London, London, UK., Yoshida M; Department of Respiratory Medicine, Division of Medicine, University College London, London, UK., van den Berge M; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bossé Y; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada., Desai TJ; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Eickelberg O; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Krasnow MA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Lafyatis R; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Nikolic MZ; Department of Respiratory Medicine, Division of Medicine, University College London, London, UK., Powell JE; Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia., Rajagopal J; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA., Rojas M; Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, OH, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cellular and Tissue Genomics, Genentech, South San Francisco, CA, USA., Seibold MA; Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.; Department of Pediatrics, National Jewish Health, Denver, CO, USA.; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA., Sheppard D; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA, USA., Shepherd DP; Department of Physics and Center for Biological Physics, Arizona State University, Tempe, AZ, USA., Sin DD; Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada., Timens W; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Tsankov AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Whitsett J; Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Xu Y; Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Banovich NE; Translational Genomics Research Institute, Phoenix, AZ, USA., Barbry P; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur and Centre National de la Recherche Scientifique, Valbonne, France.; 3IA Côte d'Azur, Nice, France., Duong TE; Department of Pediatrics, Division of Respiratory Medicine, University of California, San Diego, La Jolla, CA, USA., Falk CS; Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany., Meyer KB; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Kropski JA; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Pe'er D; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schiller HB; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany., Tata PR; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA., Schultze JL; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen and University of Bonn, Bonn, Germany., Teichmann SA; Wellcome Sanger Institute, Hinxton, Cambridge, UK.; Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, UK., Misharin AV; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Nawijn MC; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Luecken MD; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany. malte.luecken@helmholtz-munich.de.; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany. malte.luecken@helmholtz-munich.de., Theis FJ; Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany. fabian.theis@helmholtz-munich.de.; TUM School of Life Sciences, Technical University of Munich, Munich, Germany. fabian.theis@helmholtz-munich.de.; Department of Mathematics, Technical University of Munich, Garching, Germany. fabian.theis@helmholtz-munich.de.

Publikováno v: Nature medicine [Nat Med] 2023 Jun; Vol. 29 (6), pp. 1563-1577. Date of Electronic Publication: 2023 Jun 08.