Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Kap Sun Yeung"'
Publikováno v:
Journal of the American Chemical Society. 144:18109-18116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f83ef3aafd19b9be1c97c01b2f8cc122
https://doi.org/10.1021/jacs.2c08332
https://doi.org/10.1021/jacs.2c08332
Autor:
Kap-Sun Yeung, Claire E Grigglestone
Publikováno v:
ACS Med Chem Lett
[Image: see text] In targeted protein degradation of kinases, key discoveries have been made specifically involving selective kinase degradation. Structural and biophysical studies on the ternary complex formation have provided a clear understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba44f53620ceb019d013ed6bceca95b9
https://doi.org/10.1021/acsmedchemlett.1c00543
https://doi.org/10.1021/acsmedchemlett.1c00543
Autor:
Kap-Sun Yeung, William R. Ewing, Jin-Quan Yu, Zhen Li, Shaoqun Qian, Nikita Chekshin, Zhen Wang, Jennifer X. Qiao, Peter T. W. Cheng
Publikováno v:
Science
Easing oxygen into arenes Although oxygen is all around us, it is often surprisingly difficult to use it for selective chemical oxidations, necessitating more expensive, wasteful alternatives. Li et al. report that careful ligand optimization produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa3a3696a054fe406c7b78a9e81cb4a
https://doi.org/10.1126/science.abg2362
https://doi.org/10.1126/science.abg2362
Autor:
Zhe Zhuang, Shuang Liu, Jin‐Tang Cheng, Kap‐Sun Yeung, Jennifer X. Qiao, Nicholas A. Meanwell, Jin‐Quan Yu
Publikováno v:
Angewandte Chemie International Edition. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f81dc081c9d489f8258e473bd81bea
https://doi.org/10.1002/anie.202207354
https://doi.org/10.1002/anie.202207354
Publikováno v:
Angew Chem Int Ed Engl
Fluorine is known to promote ortho-C-H metalation. Based upon this reactivity, we employed an activated norbornene that traps the ortho-palladation intermediate and is then relayed to the meta position, leading to meta-selective C-H arylation of fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13aa156d9c01d651b422480b6f8f51fe
https://doi.org/10.1002/ange.202002865
https://doi.org/10.1002/ange.202002865
Publikováno v:
Angewandte Chemie International Edition. 59:9594-9600
The use of chiral transient directing groups (TDGs) is a promising approach for developing PdII -catalyzed enantioselective C(sp3 )-H activation reactions. However, this strategy is challenging because the stereogenic center on the TDG is often far f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc863587f0e7bbac228adc80c08006e
https://doi.org/10.1002/anie.202000532
https://doi.org/10.1002/anie.202000532
Autor:
Shuang Liu, Zhe Zhuang, Jennifer X. Qiao, Kap-Sun Yeung, Shun Su, Emily C. Cherney, Zheming Ruan, William R. Ewing, Michael A. Poss, Jin-Quan Yu
Publikováno v:
J Am Chem Soc
γ-Lactams form important structural cores of a range of medicinally-relevant natural products and clinical drugs, principal examples being the new generation of immunomodulatory imide drugs (IMiDs) and the brivaracetam family. Compared to convention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e435084c43e9a77b57719fbe46530c
https://europepmc.org/articles/PMC9116424/
https://europepmc.org/articles/PMC9116424/
Publikováno v:
Israel Journal of Chemistry. 60:416-418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac2b27e0f5f9c288c0baebb5fb7d625
https://doi.org/10.1002/ijch.201900134
https://doi.org/10.1002/ijch.201900134
Publikováno v:
J Am Chem Soc
Controlling site selectivity of C–H activation without using a directing group remains a significant challenge. While Pd(II) catalysts modulated by a mutually repulsive pyridine-type ligand have been shown to favor the relatively electron-rich carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3160a0e51761b3ab0bde534fcac9b6
https://doi.org/10.1021/jacs.9b07887
https://doi.org/10.1021/jacs.9b07887
Publikováno v:
Chemistry - A European Journal. 25:2199-2202
We herein report the first example of a 2-pyridone accelerated non-directed C–H cyanation with an arene as the limiting reagent. This protocol is compatible with a broad scope of arenes, including advanced intermediates, drug molecules, and natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa6fdddd29eebe897b7dd861327f9f2
https://doi.org/10.1002/chem.201805772
https://doi.org/10.1002/chem.201805772