Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM):results from an international, double-blind, randomised, controlled, phase 3 study

Autor: Srdan Verstovsek, Aaron T Gerds, Alessandro M Vannucchi, Haifa Kathrin Al-Ali, David Lavie, Andrew T Kuykendall, Sebastian Grosicki, Alessandra Iurlo, Yeow Tee Goh, Mihaela C Lazaroiu, Miklos Egyed, Maria Laura Fox, Donal McLornan, Andrew Perkins, Sung-Soo Yoon, Vikas Gupta, Jean-Jacques Kiladjian, Nikki Granacher, Sung-Eun Lee, Luminita Ocroteala, Francesco Passamonti, Claire N Harrison, Barbara J Klencke, Sunhee Ro, Rafe Donahue, Jun Kawashima, Ruben Mesa, Adi Shacham Abulafia, Bjorn Andreasson, Anna Angona, Rosa Ayala, Soo-Mee Bang, Bruce Bank, Fiorenza Barraco, Eloise Beggiato, Fleur Samantha Benghiat, MassimiliaNo Bonifacio, Claire Bories, Gabriela Borsaru, Mette Brabrand, Andrei Braester, Andes Broliden, Veronika Buxhofer-Ausch, Nathalie Cambier, Marianna Caramella, Benjamin Carpentier, Nicola Cascavilla, Maria Giraldo Castellano, Hung Chang, Chih-Cheng Chen, June-Won Cheong, Yunsuk Choi, Philip Choi, Maria Teresa Corsetti, Isabel Montero Cuadrado, Julia Cunningham, Gandhi Laurent Damaj, Valerio De Stefano, Robert Delage, Regina Garcĺa Delgado, Jose Miguel Torregrosa Diaz, Péter Dombi, Viviane Dubruille, Miklós Egyed, Daniel El Fassi, Anna Elinder-Camburn, Elena Maria Elli, Martin Ellis, Carmen Fava, Salman Fazal, Angela Fleischman, Lynda Foltz, Laura Fox, Nashat Gabrail, Jose Valentĺn Garcĺa-Gutiérrez, Aaron Gerds, Stephane Girault, Heinz Gisslinger, Alexandru Gluvacov, Joachim Göthert, Evgeni (Evgueniy) Hadjiev (Hadzhiev), Kaoutar Hafraoui, Aryan Hamed, Claire Harrison, Hans Hasselbalch, Hanns Hauser, Mark Heaney, Holger Hebart, Jesus Maria Hernandez Rivas, Victor Higuero Saavedra, Christopher Hillis, Hsin-An Hou, Jonathan How, Daniel Huang, Marek Hus, Arpad Illés, Alessandro Isidori, Vadim Ivanov, Peter Johansson, Chul Won Jung, Ilya Kirgner, Maya Koren-Michowitz, Steffen Koschmieder, Szabolcs Ors Kosztolanyi, Natalia Kreiniz, Andrew Kuykendall, Jonathan Lambert, Kamel Laribi, Axelle Lascaux, Noa Lavie, Mihaela Lazaroiu, Michael Leahy, Ewa Lech-Maranda, Won Sik Lee, Ollivier Legrand, Roberto Lemoli, James Liang, Sung-Nam Lim, Michael Loschi, Alessandro Lucchesi, Ioan Macarie, Jean-Pierre Marolleau, Maurizio Martelli, Jiri Mayer, James McCloskey, Christopher McDermott, Brandon McMahon, Priyanka Mehta, Gábor Mikala, Dragana Milojkovic, Philippe Mineur, Elena Mishchenko, Joon Ho Moon, Zsolt Nagy, Srinivasan Narayanan, Casey O'Connell, Stephen Oh, Mario Ojeda-Uribe, Kiat Hoe Ong, Folashade Otegbeye, Jeanne Palmer, Fabrizio Pane, Andrea Patriarca, Giuseppe Pietrantuono, Mark Plander, Uwe Platzbecker, Ritam Prasad, Witold Prejzner, Tobias Rachow, Atanas Radinoff, László Rejtő, Ciro Rinaldi, Tadeusz Robak, Maria Angeles Fernandez Rodriguez, Aaron Ronson, David Ross, Tomasz Sacha, Parvis Sadjadian, Antonio Salar, Guillermo Sanz Santillana, Christof Scheid, Aline Schmidt, Marianne Tang Severinsen, Vera Stoeva, Paweł Szwedyk, Mario Tiribelli, Karolin Trautmann-Grill, Amy Trottier, Nikolay Tzvetkov, Janusz van Droogenbroeck, Alessandro Vannucchi, Nicola Vianelli, Nikolas von Bubnoff, Dominik Wolf, Dariusz Woszczyk, Tomasz Woźny, Tomasz Wróbel, Blanca Xicoy, Su-Peng Yeh

Publikováno v: Verstovsek, S, Gerds, A, Vannucchi, A, Vannucchi, A, Al-Ali, H K, Lavie, D, Kuykendall, A T, Grosicki, S, Iurlo, A, Goh, Y T, Lazaroiu, M C, Egyed, M, Fox, M L, McLornan, D, Harrison, C N, Perkins, A, Yoon, S S, Gupta, V, Kiladjian, J J, Granacher, N, Lee, S E, Ocroteala, L, Passamonti, F, Klencke, B J, Ro, S, Donahue, R, Kawashima, J, Mesa, R, MOMENTUM Study Investigators & Severinsen, M T 2023, ' Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM) : results from an international, double-blind, randomised, controlled, phase 3 study ', The Lancet, vol. 401, no. 10373, pp. 269-280 . https://doi.org/10.1016/S0140-6736(22)02036-0

BACKGROUND: Janus kinase (JAK) inhibitors approved for myelofibrosis provide spleen and symptom improvements but do not meaningfully improve anaemia. Momelotinib, a first-in-class inhibitor of activin A receptor type 1 as well as JAK1 and JAK2, has s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0a29b32da77b75b50f0a41ca3581cd
https://vbn.aau.dk/da/publications/00e2be43-3d7e-42ce-a974-744fc61bd9e2

Dual-tracer PET/CT scan after injection of combined [

Autor: Nadia, Withofs, Yves, Beguin, François, Cousin, Tino, Tancredi, Paolo, Simoni, Victoria, Alvarez-Miezentseva, Bernard, De Prijck, Kaoutar, Hafraoui, Christophe, Bonnet, Frédéric, Baron, Roland, Hustinx, Jo, Caers

Publikováno v: Hematological oncology. 37(2)

The detection rates of whole-body combined [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29b9a635ef6b275aae3536ecdb072662
https://pubmed.ncbi.nlm.nih.gov/30821017

Erythropoietin therapy after allogeneic hematopoietic cell transplantation: a prospective, randomized trial

Autor: Yves Beguin, Kaoutar Hafraoui, Gaëtan Vanstraelen, Frédéric Baron, Aurélie Jaspers, Laurence Seidel, Christophe Bonnet, Evelyne Willems

Publikováno v: Blood. 124:33-41

We conducted a prospective randomized trial to assess hemoglobin (Hb) response to recombinant human erythropoietin (rhEPO) therapy after hematopoietic cell transplantation (HCT). Patients (N = 131) were randomized (1:1) between no treatment (control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cb34fd8a443184a473d99f2baba71c
https://doi.org/10.1182/blood-2014-01-546333

Darbepoetin‐alfa and intravenous iron administration after autologous hematopoietic stem cell transplantation: A prospective multicenter randomized trial

Autor: Laurence Seidel, Gaëtan Vanstraelen, Sophie Servais, Evelyne Willems, Rik Schots, Georges Fillet, Yves Beguin, Johan Maertens, Kaoutar Hafraoui, Christophe Bonnet, Bernard De Prijck, Frédéric Baron, Aurélie Jaspers

Publikováno v: Europe PubMed Central

We conducted a randomized study analyzing the impact of darbepoetin alfa (DA) administration with or without intravenous (i.v.) iron on erythroid recovery after autologous hematopoietic cell transplantation (HCT). Patients were randomized between no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cf5387ac435f699cfbedb9b47aec2f
https://doi.org/10.1002/ajh.23552

Erythropoietin therapy after allogeneic hematopoietic cell transplantation has no impact on long-term survival

Autor: Aurélie, Jaspers, Frédéric, Baron, Sophie, Servais, Marie, Lejeune, Évelyne, Willems, Laurence, Seidel, Kaoutar, Hafraoui, Christophe, Bonnet, Yves, Beguin

Publikováno v: American journal of hematology. 90(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2aee592d429279e11228e9f4c9b95ade
https://pubmed.ncbi.nlm.nih.gov/26113363