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Akademický článek

2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Autor: Wuguo Li, Qing Zhang, Kaotan Chen, Zhenhua Sima, Jingli Liu, Qiang Yu, Jiawei Liu

Publikováno v: BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-13 (2019)

Abstract Background Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in ho

Externí odkaz: https://doaj.org/article/daddbdf6f6384e0fb3d256951c3bc577

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Akademický článek

Screening of neuraminidase inhibitory activities of some medicinal plants traditionally used in Lingnan Chinese medicines

Autor: Jiawei Liu, Mian Zu, Kaotan Chen, Li Gao, Huan Min, Weiling Zhuo, Weiwen Chen, Ailin Liu

Publikováno v: BMC Complementary and Alternative Medicine, Vol 18, Iss 1, Pp 1-11 (2018)

Abstract Background Neuraminidase (NA) is one of the key surface protein of the influenza virus, and has been established as a primary drug target for anti-influenza therapies. This study aimed to screen bioactive herbal extracts from some medicinal

Externí odkaz: https://doaj.org/article/a6e5ff34fc3942b781a734d741ed9b20

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2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Autor: Zhenhua Sima, Jingli Liu, Jiawei Liu, Wuguo Li, Kaotan Chen, Qing Zhang, Qiang Yu

Publikováno v: BMC Complementary and Alternative Medicine
BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-13 (2019)

Background Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5a0a89bd224e1e197d10299f450bc7
https://doi.org/10.1186/s12906-019-2440-9

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Additional file 1: of 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Autor: Wuguo Li, Zhang, Qing, Kaotan Chen, Zhenhua Sima, Jingli Liu, Yu, Qiang, Jiawei Liu

Figure S1. IR spectrum of 2-ethoxystypandrone. Figure S2. ESI-MS spectrum of 2-ethoxystypandrone Figure S3. HR-ESI-MS spectrum of 2-ethoxystypandrone Figure S4. 1H-NMR spectrum of 2-ethoxystypandrone Figure S5. 1H-1H COSY spectrum of 2-ethoxystypandr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5270f75b1bf209fdda435a35081d8e09

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Screening of neuraminidase inhibitory activities of some medicinal plants traditionally used in Lingnan Chinese medicines

Autor: Li Gao, Kaotan Chen, Mian Zu, Huan Min, Wei-Wen Chen, Weiling Zhuo, Jiawei Liu, Ai-Lin Liu

Publikováno v: BMC Complementary and Alternative Medicine
BMC Complementary and Alternative Medicine, Vol 18, Iss 1, Pp 1-11 (2018)

Background Neuraminidase (NA) is one of the key surface protein of the influenza virus, and has been established as a primary drug target for anti-influenza therapies. This study aimed to screen bioactive herbal extracts from some medicinal plants tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d8cc67abe4dd3ff24677fb6ad3c99d
https://pubmed.ncbi.nlm.nih.gov/29558938

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[Active neuraminidase constituents of Polygonum cuspidatum against influenza A(H1N1) influenza virus]

Autor: Wei-Ling Zhou, Jia-Wei Liu, Mian Zu, Ai-Lin Liu, Kaotan Chen, Wei-Wen Chen, Zi-Ning He, Guanhua Du

Publikováno v: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 37(20)

Objective To isolate and identify active neuraminidase constituents of Polygonum cuspidatum against influenza A (H1N1) influenza virus. Method On the basis of the bioassay-guided fractionation,such chromatographic methods as silica gel, sephadex LH-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a62fcce938c004449605031c6e7234
https://pubmed.ncbi.nlm.nih.gov/23311155

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