Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kaoru Toyosawa"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 3, Pp 340-348 (2008)
We investigated the chronic functional and histopathological changes in the sciatic nerve and lens of streptozotocin (STZ)-diabetic rats and evaluated the preventive effects of ranirestat (AS-3201), a potent aldose reductase inhibitor, on these chang
Externí odkaz:
https://doaj.org/article/175beb06cfe24e73892c416d4ea4e89c
Autor:
Takatoshi Koujitani, Izumi Matsumoto, Tomoaki Tochitani, Juki Kimura, Hitoshi Funabashi, Kaoru Toyosawa, Kohei Hoshino, Mami Kouchi
Publikováno v:
Journal of Toxicologic Pathology. 26:187-191
The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background pathology of this species is scarce. Here, we report a case of rhabdomyosarcoma that spontaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa14cb71568f5b173e08be125ad524d
https://doi.org/10.1293/tox.26.187
https://doi.org/10.1293/tox.26.187
Autor:
Mami Kouchi, Yoshiko Michimae, Takatoshi Koujitani, Hitoshi Funabashi, Tomoaki Tochitani, Takaki Seki, Kaoru Toyosawa, Kazuo Okimoto, Izumi Matsumoto
Publikováno v:
Journal of Toxicologic Pathology
A female congenic rat produced by repeated backcrossing of Nihon rats, a model for hereditary renal cell carcinoma, to Brown Norway rats was necropsied at 24 months of age. At necropsy, a white mass about 1 centimeter in size was observed in the thor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ae6e21b06c52649e019a70c35d04c5
https://doi.org/10.1293/tox.25.41
https://doi.org/10.1293/tox.25.41
Autor:
Takaki Seki, Tomoaki Tochitani, Mami Kouchi, Izumi Matsumoto, Kaoru Toyosawa, Yoshiko Michimae, Takatoshi Koujitani, Hitoshi Funabashi
Publikováno v:
Journal of Toxicologic Pathology
In the present study, we investigated the histological, immunohistochemical and ultrastructural characteristics of cytoplasmic blood plasma inclusions that spontaneously occurred in a rat liver. Histologically, a number of cytoplasmic inclusions were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d240cd1ee43a65cb4bce261eae2618f
https://doi.org/10.1293/tox.24.245
https://doi.org/10.1293/tox.24.245
Autor:
Mami Kouchi, Takatoshi Koujitani, Takaki Seki, Izumi Matsumoto, Shinichi Mikami, Kaoru Toyosawa, Tadashi Inoue, Yoshiko Michimae
Publikováno v:
Journal of Toxicologic Pathology. 21:119-122
An immunohistochemical staining method for prohibitin, a 30-kDa protein located in the inner membrane of mitochondria, is used for detection of mitochondria on formalin-fixed paraffin-embedded sections. Methapyrilene hydrochloride (MP), which is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e37cc882c647db8b75ebda2d513d62ff
https://doi.org/10.1293/tox.21.119
https://doi.org/10.1293/tox.21.119
Autor:
Masatoshi Komiyama, Tetsuya Adachi, Kazuyasu Kijima, Kaoru Toyosawa, Masashi Yasuba, Chisato Mori, Nobuo Matsuoka
Publikováno v:
Toxicology and Applied Pharmacology. 200:103-110
To investigate the effects of di(2-ethylhexyl) phthalate (DEHP) on gene expression in rat testis, 6-week-old male Sprague-Dawley rats were given a single oral dose of 20 or 2000 mg/kg and euthanized 3, 6, 24, or 72 h thereafter. Terminal deoxynucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254539a029a3c05e6b8499fd9fadbaa0
https://doi.org/10.1016/j.taap.2004.03.015
https://doi.org/10.1016/j.taap.2004.03.015
Autor:
Kaoru Toyosawa, Masao Hirose, Kunitoshi Mitsumori, Kohji Tanaka, Toshio Imai, Kazuo Yasuhara, Takatoshi Koujitani
Publikováno v:
Toxicologic Pathology. 31:491-495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78fdcdfbf172d6e391ce8f0392def5ea
https://doi.org/10.1080/01926230309796
https://doi.org/10.1080/01926230309796
Publikováno v:
Cancer Letters. 192:199-203
The mRNA profiles for peroxisome proliferator activated receptor (PPAR) alpha and human c-Ha-ras genes were determined by real-time semi-quantitative polymerase chain reaction analysis of hepatocellular adenomas induced by di(2-ethylhexyl)phthalate (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a96e400aea101a187a5830b2ff16b6
https://doi.org/10.1016/s0304-3835(02)00714-0
https://doi.org/10.1016/s0304-3835(02)00714-0
Autor:
Masaya Takaoka, Shinya Sehata, Takanori Maejima, Toshio Imai, Mikinori Torii, Hiroshi Satoh, Kaoru Toyosawa, Zen-yo Tanakamaru, Tamiko Adachi, Shigeru Hisada, Makoto Ueda, Hiroyuki Ogasawara, Masahiro Matsumoto, Kiyoshi Kobayashi, Mamoru Mutai, Toshimi Usui
Publikováno v:
Toxicologic Pathology. 31:191-199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0446db803af3ee62ecc48b63da604c6f
https://doi.org/10.1080/01926230309812
https://doi.org/10.1080/01926230309812
Autor:
Hiroshi Kato, Satoshi Kimura, Kaoru Toyosawa, Kaori Kato, Akinori Nomura, Yasuji Furutani, Mayumi Ohue, Takashi Kadowaki
Publikováno v:
Diabetes. 50:113-122
The mechanism by which the specific β3-adrenoceptor agonist AJ-9677 relieves insulin resistance in vivo was investigated by studying its effects in the white and brown adipose tissues of the KK-Ay/Ta diabetic obese mouse model. AJ-9677 reduced the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc18710eba091955ed955c0427db665a
https://doi.org/10.2337/diabetes.50.1.113
https://doi.org/10.2337/diabetes.50.1.113