Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Kaoru TOHYAMA"'
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Naohito Fujishima, Junki Kohmaru, Souichi Koyota, Keiji Kuba, Tomoo Saga, Ayumi Omokawa, Yuki Moritoki, Shigeharu Ueki, Fumihiro Ishida, Shinji Nakao, Akira Matsuda, Akiko Ohta, Kaoru Tohyama, Hiroshi Yamasaki, Kensuke Usuki, Yasuhiro Nakashima, Shinya Sato, Yasushi Miyazaki, Yasuhito Nannya, Seishi Ogawa, Kenichi Sawada, Kinuko Mitani, Makoto Hirokawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated. The PRCA2004/2006 study showed that poor responses to immunosuppression
Externí odkaz:
https://doaj.org/article/5b01912c18ce4399a6aa2f25513dfa7f
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Effective phagocytosis is crucial for host defense against pathogens. Macrophages entrap pathogens into a phagosome and subsequently acidic lysosomes fuse to the phagosome. Previous studies showed the pivotal role of actin-remodeling mediate
Externí odkaz:
https://doaj.org/article/d5dfff707a7f48d58d3fc7b9c6932ac2
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271245 (2022)
The prognosis of the patients with inoperable or advanced granulosa cell tumors (GCTs) is still poor, and therefore it is important to establish a novel treatment strategy. Here we investigated the in vitro effects of a histone deacetylase inhibitor,
Externí odkaz:
https://doaj.org/article/91592187d52e48a19ced3bd2d0737789
Autor:
Tatsumi Kawakami, Jinsong He, Hiroyuki Morita, Kunio Yokoyama, Hiroaki Kaji, Chisato Tanaka, Shin-ichiro Suemori, Kaoru Tohyama, Yumi Tohyama
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84704 (2014)
Neutrophils play a crucial role in host defence. In response to a variety of inflammatory stimulation, they form neutrophil extracellular traps (NETs). NETs are extracellular structures composed of chromatin fibers decorated with antimicrobial protei
Externí odkaz:
https://doaj.org/article/52c12ac013524ae4990be28e3c030898
Autor:
Akira Yoshida, Kouichi Zokumasu, Yuji Wano, Takahiro Yamauchi, Shin Imamura, Kazutaka Takagi, Shinji Kishi, Yoshimasa Urasaki, Kaoru Tohyama, Takanori Ueda
Publikováno v:
Haematologica, Vol 97, Iss 9 (2012)
Background Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Survivin is a member of the inhibitor of apoptosis family and suppresses apoptosis. Survivin also f
Externí odkaz:
https://doaj.org/article/c143076dd9d544c8bc11bcd387b03766
Autor:
Zhijian Qian, Tongyu Zhu, Howard Ozer, You-Yang Zhao, Amber Seba, Kaoru Tohyama, Nupur Mittal, Chao Hu, Wenshu Li, Yue Sheng, Liping Li
Deletion of the chromosome 5q [del(5q)] is one of the most common cytogenetic abnormalities observed in patients with de novo myelodysplastic syndromes (MDS) and therapy-related MDS or acute myeloid leukemia (t-MDS/tAML). Emerging evidence indicates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4def852c40f7f07cf2a850b9f333b96d
https://doi.org/10.1158/0008-5472.c.6508988.v1
https://doi.org/10.1158/0008-5472.c.6508988.v1
Autor:
Zhijian Qian, Tongyu Zhu, Howard Ozer, You-Yang Zhao, Amber Seba, Kaoru Tohyama, Nupur Mittal, Chao Hu, Wenshu Li, Yue Sheng, Liping Li
Supplemental Figure 1. Indo suppresses beta-catenin expression. (A) Luciferase reporter assay of beta-catenin transcription activity. (B) beta-catenin expression in MDSL and UoC-M1 cells after Indo treatment for 72 hours. *, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadb3bcf9e10202ca78e1abd1ec7b6c8
https://doi.org/10.1158/0008-5472.22414466.v1
https://doi.org/10.1158/0008-5472.22414466.v1
Autor:
Takako Nakahara, Mamoru Ouchida, Akira Kitanaka, Kaoru Tohyama, Kanae Sakakibara, Shin ichiro Suemori, Nami Kurozumi, Takayuki Tsujioka, Masaki Takeuchi, Misako Shibakura
Publikováno v:
Cancer Science
A novel proteasome deubiquitinase inhibitor, VLX1570, has been highlighted as a promising therapeutic agent mainly for lymphoid neoplasms and solid tumors. We examined in vitro effects of VLX1570 on eight myeloid and three lymphoid leukemia cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d8b084c9f667de42a169bde4c0f818
https://doi.org/10.1111/cas.14982
https://doi.org/10.1111/cas.14982
Autor:
Bjørn Tore Gjertsen, Anders Molven, Kaoru Tohyama, Mihaela Popa, Astrid Olsnes Kittang, Monica Hellesøy, Biju Parekkadan, Rakel Brendsdal Forthun, Jungwoo Lee, Sahba Shafiee, Randi Hovland, Pascal Gelebart, Emmet McCormack
Publikováno v:
Br J Haematol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f33ebf6b01b15d8268fae445f102f9f
https://doi.org/10.1111/bjh.17372
https://doi.org/10.1111/bjh.17372