Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kaoru Sota"'
Publikováno v:
ChemInform. 21
The preparation of D-penicillamine (5) was achieved by a single-step reaction of benzylpenicillin potassium salt (1) with arylamines (2, 7, and 13). The intermediates in these reactions should be the penicilloic acid α-amides. The structures of by-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24fe2758a357e1dbd5c366d8cadd7bdc
https://doi.org/10.1002/chin.199002308
https://doi.org/10.1002/chin.199002308
Publikováno v:
Chemical and Pharmaceutical Bulletin. 36:1957-1962
Benzylpenicilloic acid α-amides (1a-d) prepared by aminolysis of benzylpenicillin were treated with arylamines (2, 7, 9 and 13a-f) in the presence of acetic acid to give D-penicillamine (3) in good yield and high purity. The structures pf the by-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e57c98bdd26beb3aecf28e611acdc78
https://doi.org/10.1248/cpb.36.1957
https://doi.org/10.1248/cpb.36.1957
Autor:
Chihiro Yokoo, Mitsuo Murata, Kaoru Sota, Takatoshi Nagate, Yoshiaki Watanabe, Masami Goi, Akira Onodera
Publikováno v:
The Journal of Antibiotics. 41:170-180
The synthesis, antibacterial activity and oral absorption of new 7 beta-[D-alpha-amino-alpha-(4-hydroxyphenyl)acetamido]cephalosporins (1) with various O-substituents at the C-3 position of a cephalosporin nucleus are described. Of these, the cephalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a2da326fe910c89ff204e4dd558f0a
https://doi.org/10.7164/antibiotics.41.170
https://doi.org/10.7164/antibiotics.41.170
Autor:
Shigeo Morimoto, Hideaki Kondoh, Takatoshi Nagate, Takashi Adachi, Yoshiaki Watanabe, Kaoru Sota
Publikováno v:
The Journal of Antibiotics. 41:966-975
(14R)-14-Hydroxy-6-O-methylerythromycin A and (14S)-epimer have been isolated as active metabolites from human urine after oral administration of 6-O-methylerythromycin A (TE-031, A-56268). The structures of these metabolites were determined by means
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b8326dfd297afed8e34ee1adb0ff0c
https://doi.org/10.7164/antibiotics.41.966
https://doi.org/10.7164/antibiotics.41.966
Autor:
Masaharu Tamai, Mitsuo Murata, Eisuke Sato, Kaoru Sota, Yuichi Kanaoka, Kiyoshi Oguma, Chihiro Yokoo
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:1098-1104
Ethly (+)-(2S, 3S) -3- [(S) -3-methyl-1- (3-methylbutylcarbamoyl) butylcarbamoyl] -2- oxirane-carboxylate (EST ; la) is expected to be useful as an oral therapeutic agent for muscular dystrophy on the basis of its potent inhibitory activities against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b716f782faf0484100f09c693a7af94
https://doi.org/10.1248/cpb.35.1098
https://doi.org/10.1248/cpb.35.1098
Autor:
Yumiko Asami, Kazuya Kameo, Kunio Ogawa, Kazuyuki Tomisawa, Shiuji Saito, Tohru Matsunaga, Kaoru Sota
Publikováno v:
Chemical and Pharmaceutical Bulletin. 37:1260-1267
2-Acetylthio-3-benzoylpropionic acid derivatives having two benzene rings or condensed-ring moieties were prepared, and tested for hypolipidemic activity in normal rats. Some of these compounds were active. 2-Acetylthio-3-[4-(phenylthio)benzoyl]propi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c60ce194dcda1c5681d8262339946c
https://doi.org/10.1248/cpb.37.1260
https://doi.org/10.1248/cpb.37.1260
Autor:
Minoru Taguchi, Katsuo Hatayama, Morihiro Mitsukuchi, Hajime Yasui, Satoshi Abe, Shohei Higuchi, Tomoyuki Ikemoto, Kaoru Sota
Publikováno v:
Chemical and Pharmaceutical Bulletin. 37:3286-3293
A series of 21-thio derivatives of 9 alpha-fluoro-11 beta,17 alpha-dihydroxy-16 beta-methyl-1,4-pregnadiene-3, 20-dione 17-esters and related compounds were synthesized and evaluated as topical antiinflammatory agents. These compounds were prepared b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd523c4c09d6399ecadbee7a4e6f13c
https://doi.org/10.1248/cpb.37.3286
https://doi.org/10.1248/cpb.37.3286
Autor:
Kaoru Sota, Yutaka Kawashima, Fusao Amanuma, Ikuo Moriguchi, Shigeru Okuyama, Yoshimoto Nakashima, M. Sato, Yuichi Hatada
Publikováno v:
Chemical and Pharmaceutical Bulletin. 34:3267-3272
4, 6-Disubstituted N-(3-piperidinopropyl)furo[3, 2-b]indole-2 carboxamide derivatives possess analgesic and antiinflammatory activities. To understand how substituents affect the biological activities, the quantitative structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ff6bf11dce81338fe45d6f6fd66694
https://doi.org/10.1248/cpb.34.3267
https://doi.org/10.1248/cpb.34.3267
Autor:
Yasuhide Tachi, Susumu Otomo, Jozi Nakagami, Kaoru Sota, Jiro Sawada, Morihiro Mitsukuchi, Masahiro Ohzeki
Publikováno v:
YAKUGAKU ZASSHI. 102:365-370
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a36fe85217cf391f602cadc1f776d6
https://doi.org/10.1248/yakushi1947.102.4_365
https://doi.org/10.1248/yakushi1947.102.4_365
Autor:
Yoshiaki Watanabe, Mitsuo Murata, Takatoshi Nagate, Kaoru Sota, Chihiro Yokoo, Akira Onodera, Masami Goi
Publikováno v:
The Journal of Antibiotics. 41:181-192
The synthesis, antibacterial activity and oral absorption in rats of 3-alkoxycarbonyl-methoxy-7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(O-substituted oxyimino)acetamido]cephalosporins (1) are described. In this cephalosporin series, 7 beta-[(Z)-2-(2-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09c87dc67e3318b91328af5e62b8b1c
https://doi.org/10.7164/antibiotics.41.181
https://doi.org/10.7164/antibiotics.41.181