Zobrazeno 1 - 10 of 76 pro vyhledávání: '"Kaoru Kiguchi"'
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Akademický článek
Progressive Metaplastic and Dysplastic Changes in Mouse Pancreas Induced by Cyclooxygenase-2 Overexpression
Autor: Jennifer K.L. Colby, Russell D. Klein, Mark J. McArthur, Claudio J. Conti, Kaoru Kiguchi, Toru Kawamoto, Penny K. Riggs, Amy I. Pavone, Janet Sawicki, Susan M. Fischer
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 8, Pp 782-796 (2008)
Cyclooxygenase-2 (COX-2) overexpression is an established factor linking chronic inflammation with metaplastic and neoplastic change in various tissues. We generated transgenic mice (BK5.COX-2) in which elevation of COX-2 and its effectors trigger a
Externí odkaz: https://doaj.org/article/1c8c6b443fb1402eaa92546ddfd47636
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4
Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes
Autor: Dharanija Rao, Steve Carbajal, Everardo Macias, John DiGiovanni, Kaoru Kiguchi
Publikováno v: Journal of Investigative Dermatology. 134:1971-1980
The nuclear transcription factor signal transducer and activator of transcription 3 (Stat3) has recently been reported to have a localized mitochondrial regulatory function. Current data suggest that mitochondrial Stat3 (mitoStat3) is necessary for m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e50b876fdaf30a47f12b5f6b903265
https://doi.org/10.1038/jid.2014.68
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5
Bile acid accelerates erbB2-induced pro-tumorigenic activities in biliary tract cancer
Autor: Kaoru Kiguchi, John DiGiovanni, Takuya Kitamura, Jaya Srivastava
Publikováno v: Molecular Carcinogenesis. 54:459-472
Although very few studies have addressed the molecular and cellular mechanisms underlying the development of biliary tract cancer (BTC), several lines of evidence suggest a role for the erbB receptor family. Overexpression and activation of erbB2 has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38ce63385b71e9350b6b3f0b6fec204a
https://doi.org/10.1002/mc.22118
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6
Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations
Autor: John DiGiovanni, Kaoru Kiguchi, Dharanija Rao, Steve Carbajal, Everardo Macias
Publikováno v: Molecular Carcinogenesis. 54:121-133
STATs play crucial roles in a wide variety of biological functions, including development, proliferation, differentiation and migration as well as in cancer development. In the present study, we examined the impact of constitutive activation of Stat3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b067db40ac61cac2f501e3428fc9985
https://doi.org/10.1002/mc.22080
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7
Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells
Autor: John DiGiovanni, Woon Gye Chung, Piyanuch Wonganan, Saijie Zhu, Zhengrong Cui, Kaoru Kiguchi
Publikováno v: Cancer Biology & Therapy. 13:908-914
Gemcitabine is a deoxycytidine analog used for the treatment of a wide range of solid tumors. Its efficacy is however often reduced due to the development of resistance. Ribonucleotide reductase M1 subunit (RRM1) is a key determinant of gemcitabine r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930d5bafe40109873f46f7220b8c39ee
https://doi.org/10.4161/cbt.20843
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8
Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis
Autor: Edward M. Mills, Katsuya Hirasaka, Kaoru Kiguchi, John DiGiovanni, Joyce E. Rundhaug, X.L. Yang, Okkyung Rho, Ellen M. Abramson, Matthew Pfeiffer, Shawn B. Bratton, Takeshi Nikawa, C. U. Lago, Sara M. Nowinski, Carol S. Trempus, Renata Colavitti, Susan M. Fischer, M. A. Kenaston
Publikováno v: Oncogene. 31:4725-4731
Decreased mitochondrial oxidative metabolism is a hallmark bioenergetic characteristic of malignancy that may have an adaptive role in carcinogenesis. By stimulating proton leak, mitochondrial uncoupling proteins (UCP1-3) increase mitochondrial respi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c052cbb465455ac771e5da9161ea5792
https://doi.org/10.1038/onc.2011.630
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9
EGFR-targeted stearoyl gemcitabine nanoparticles show enhanced anti-tumor activity
Autor: John DiGiovanni, Michael A. Sandoval, Brian R. Sloat, Kaoru Kiguchi, Zhengrong Cui, Amit Kumar, Dharmika S.P. Lansakara-P, B. Leticia Rodriguez
Publikováno v: Journal of Controlled Release. 157:287-296
Previously, it was shown that a novel 4-(N)-stearoyl gemcitabine nanoparticle formulation was more effective than gemcitabine hydrochloride in controlling the growth of model mouse or human tumors pre-established in mice. In the present study, the fe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edf665957a86f94ecc40556a13830fd
https://doi.org/10.1016/j.jconrel.2011.08.015
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10
In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles
Autor: John DiGiovanni, Brian R. Sloat, Kaoru Kiguchi, Woon Gye Chung, Michael A. Sandoval, Zhengrong Cui, Dharmika S.P. Lansakara-P, Dong Li, Philip Proteau
Publikováno v: International Journal of Pharmaceutics. 409:278-288
Gemcitabine (Gemzar ® ) is the first line treatment for pancreatic cancer and often used in combination therapy for non-small cell lung, ovarian, and metastatic breast cancers. Although extremely toxic to a variety of tumor cells in culture, the cli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f01efe9b6fc9e86a3f50c5789810e6f
https://doi.org/10.1016/j.ijpharm.2011.02.037
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