Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kaoru Inouye"'
Autor:
Tomohiro Ito, Yoko Takeuchi, Keiko Nohara, Chiharu Tohyama, Xiaoqing Pan, Kaoru Inouye, Yuichi Miyabara, Haruko Nagai
Publikováno v:
Toxicology. 204:51-60
Dioxin-like polychlorinated biphenyls (PCBs) exert their toxicities by activating the arylhydrocarbon receptor (AhR), a ligand-dependent transcription factor, in a similar manner to the most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239a474995d1c4fc8c7fa08164b5e256
https://doi.org/10.1016/j.tox.2004.06.024
https://doi.org/10.1016/j.tox.2004.06.024
Autor:
Keiko Nohara, Chiharu Tohyama, Toshitada Takemori, Tomohiro Ito, Kaoru Inouye, Xiaoqing Pan, Hidekazu Fujimaki, Yoshimasa Takahashi
Publikováno v:
Toxicological Sciences. 74:315-324
In the humoral immune response to an invasion of foreign antigens, B cells differentiate into low-affinity antibody-forming cells (AFCs) that mainly secrete IgM or, through germinal center (GC) formation, into high-affinity AFCs that secrete IgG-clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ac1e2f7fa826bf073066136c24e0b1
https://doi.org/10.1093/toxsci/kfg132
https://doi.org/10.1093/toxsci/kfg132
Autor:
Shin ichi Tsukumo, Kaoru Inouye, Hideko Sone, Chiharu Tohyama, Hidekazu Fujimaki, Keiko Nohara
Publikováno v:
Toxicology. 172:49-58
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to suppress both cellular and humoral immunity. Effector T cell-derived type-2 cytokines, including IL-4 and IL-5, play pivotal roles in humoral immunity. Herein, we studied whether TCDD affects typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9522a7f1314f24c7137761a9dfc86fd4
https://doi.org/10.1016/s0300-483x(01)00582-0
https://doi.org/10.1016/s0300-483x(01)00582-0
Publikováno v:
Journal of Biological Chemistry. 275:3737-3740
Although it is well established that Ras requires membrane localization for activation of its target molecule, Raf-1, the reason for this requirement is not fully understood. In this study, we found that modified Ras, which is purified from Sf9 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8decb1d58e2dbbd2048ed81fc91ff77d
https://doi.org/10.1074/jbc.275.6.3737
https://doi.org/10.1074/jbc.275.6.3737
Autor:
Yoshiaki Fujii-Kuriyama, Hozumi Motohashi, Yoshimi Miyamoto, Hikari Murai, Takehiro Suzuki, Kaoru Inouye, Kana Ao, Masayuki Yamamoto, Keiko Nohara, Xiaoqing Pan, Chiharu Tohyama
Publikováno v:
International immunology. 21(7)
The ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) has been implicated in various immune functions. Our previous studies have shown that AhR activation by exposure of ovalbumin (OVA)-immunized mice to the potent ligand 2,3,7,8-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a137a95466a5d123c986e6a599a6a76f
https://pubmed.ncbi.nlm.nih.gov/19461128
https://pubmed.ncbi.nlm.nih.gov/19461128
Publikováno v:
Toxicology letters. 177(1)
Our previous study showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure of NC/Nga mice, a mouse model of atopic dermatitis, induces no dermal changes. In the present study, to investigate whether TCDD exacerbates atopic dermatitis-like ski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dfde8342a54af9ce4a40e35f9f88a0
https://pubmed.ncbi.nlm.nih.gov/18272299
https://pubmed.ncbi.nlm.nih.gov/18272299
Autor:
Keiko Nohara, Yoshiaki Fujii-Kuriyama, Azumi Hida, Xiaoqing Pan, Hozumi Motohashi, Shin-ichi Tsukumo, Haruko Nagai, Chiharu Tohyama, Kaoru Inouye, Masayuki Yamamoto, Tomohiro Ito
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(5)
The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix-PER-ARNT-SIM superfamily. Xenobiotics, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, bind the receptor and trigger diverse biological reactions. Thym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab2bb0430713bae7530e737e1225580
https://pubmed.ncbi.nlm.nih.gov/15728486
https://pubmed.ncbi.nlm.nih.gov/15728486
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 70(1)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to suppress antigen-specific antibody production in humoral immune reactions, but the precise mechanism remains unclear. Since T cell activation and subsequent production of type 2 helper T (Th2) ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fa8dc904ecb1f83404d83567848303
https://pubmed.ncbi.nlm.nih.gov/12388834
https://pubmed.ncbi.nlm.nih.gov/12388834
Publikováno v:
FEBS letters. 507(3)
The mechanism of Ras-induced Raf-1 activation is not fully understood. Previously, we identified a 400-kDa protein complex as a Ras-dependent Raf-1 activator. In this study, we identified B-Raf as a component of this complex. B-Raf was concentrated d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d442921c07a0678cd5a2c7b5ba20488
https://pubmed.ncbi.nlm.nih.gov/11696358
https://pubmed.ncbi.nlm.nih.gov/11696358
Publikováno v:
Proceedings of the Japan Academy. 31:587-591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28dfa4dd278bfd381cc061eea0084e74
https://doi.org/10.2183/pjab1945.31.587
https://doi.org/10.2183/pjab1945.31.587