Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kaoru Beppu"'
Autor:
Yoshiteru Shimoda, Kaoru Beppu, Yoko Ikoma, Yosuke M. Morizawa, Satoshi Zuguchi, Utaro Hino, Ryutaro Yano, Yuki Sugiura, Satoru Moritoh, Yugo Fukazawa, Makoto Suematsu, Hajime Mushiake, Nobukazu Nakasato, Masaki Iwasaki, Kenji F. Tanaka, Teiji Tominaga, Ko Matsui
Publikováno v:
Neurobiology of Disease, Vol 163, Iss , Pp 105602- (2022)
Unlike an electrical circuit, the hardware of the brain is susceptible to change. Repeated electrical brain stimulation mimics epileptogenesis. After such “kindling” process, a moderate stimulus would become sufficient in triggering a severe seiz
Externí odkaz:
https://doaj.org/article/26ed65a25a8046279518fd7b90078375
Autor:
Yosuke M. Morizawa, Mami Matsumoto, Yuka Nakashima, Narumi Endo, Tomomi Aida, Hiroshi Ishikane, Kaoru Beppu, Satoru Moritoh, Hitoshi Inada, Noriko Osumi, Eiji Shigetomi, Schuichi Koizumi, Guang Yang, Hirokazu Hirai, Kohichi Tanaka, Kenji F. Tanaka, Nobuhiko Ohno, Yugo Fukazawa, Ko Matsui
Publikováno v:
Nature Neuroscience. 25:1458-1469
Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia participates in sculpting the neuronal circuits through synapse engulfment. However, whether glial involvement i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350e14d4d2dda9687414ccbacc3543e5
https://doi.org/10.1038/s41593-022-01184-5
https://doi.org/10.1038/s41593-022-01184-5
Autor:
Yoshiteru Shimoda, Kaoru Beppu, Yoko Ikoma, Yosuke M. Morizawa, Satoshi Zuguchi, Utaro Hino, Ryutaro Yano, Yuki Sugiura, Satoru Moritoh, Yugo Fukazawa, Makoto Suematsu, Hajime Mushiake, Nobukazu Nakasato, Masaki Iwasaki, Kenji F. Tanaka, Teiji Tominaga, Ko Matsui
Publikováno v:
Neurobiology of Disease, Vol 163, Iss, Pp 105602-(2022)
Unlike an electrical circuit, the hardware of the brain is susceptible to change. Repeated electrical brain stimulation mimics epileptogenesis. After such “kindling” process, a moderate stimulus would become sufficient in triggering a severe seiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07c61eadf910b2bcd75543d92593a31
https://pubmed.ncbi.nlm.nih.gov/34954320
https://pubmed.ncbi.nlm.nih.gov/34954320
Publikováno v:
The Journal of physiologyReferences. 599(7)
Key points Recent studies have repeatedly demonstrated the cross-talk of heterogeneous signals between neuronal and glial circuits. Here, we investigated the mechanism and the influence of physiological interactions between neurons and glia in the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2d4e83f939ebcb11495a0c542ef777
https://pubmed.ncbi.nlm.nih.gov/33590888
https://pubmed.ncbi.nlm.nih.gov/33590888
Autor:
Kayo Nishizawa, Yukari Takahashi, Shin-ichi Muramatsu, Kazuto Kobayashi, Keiko Ikeda, Hiroshi Onimaru, Kyo Koizumi, Ryosuke Kaneko, Ko Matsui, Yuchio Yanagawa, Kaoru Beppu, Hiromu Yawo, Hiroyuki Igarashi, Toru Ishizuka, Fusao Kato
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Rats are excellent animal models for experimental neuroscience. However, the application of optogenetics in rats has been hindered because of the limited number of established transgenic rat strains. To accomplish cell-type specific targeting of an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6fc22f85970af4b1894381081b5af4
http://hdl.handle.net/10097/00126898
http://hdl.handle.net/10097/00126898
Autor:
Fumihiko Furuya, Kyota Fujita, Kaoru Beppu, Nozomi Akimoto, Yuki Mori, Anastasia Kalashnikova, Daichi Tomonaga, Leonid P. Churilov, Toshihiko Katafuchi, Yuko Okuno, Mami Noda, Hiroki Shimura, Masataka Ifuku
Publikováno v:
Glia. 63:906-920
l-tri-iodothyronine (3, 3', 5–triiodothyronine; T3) is an active form of the thyroid hormone (TH) essential for the development and function of the CNS. Though nongenomic effect of TH, its plasma membrane–bound receptor, and its signaling has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd6e2667bb8590e88151e3f3ce281b3
https://doi.org/10.1002/glia.22792
https://doi.org/10.1002/glia.22792
Autor:
Kaoru Beppu, Ryuichi Shigemoto, Kenji F. Tanaka, Takuya Sasaki, Yugo Fukazawa, Ko Matsui, Akihiro Yamanaka
Publikováno v:
Neuron. 81:314-320
SummaryThe brain demands high-energy supply and obstruction of blood flow causes rapid deterioration of the healthiness of brain cells. Two major events occur upon ischemia: acidosis and liberation of excess glutamate, which leads to excitotoxicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add7d13c0585ef289337af98aa673948
https://doi.org/10.1016/j.neuron.2013.11.011
https://doi.org/10.1016/j.neuron.2013.11.011
Autor:
Masataka Ifuku, Yuichiro Kojima, Yuko Okuno, Rolf Sprengel, Nozomi Akimoto, Mizuho A. Kido, Rika Shinagawa, Mami Noda, Kyota Fujita, Yuki Kosai, Kaoru Beppu, Junichi Nabekura, Yuki Mori, Yukiko Yamakawa
Publikováno v:
Glia. 61:881-891
Microglia express AMPA (α-amino-hydroxy-5-methyl-isoxazole-4-propionate)-type of glutamate (Glu) receptors (AMPAR), which are highly Ca(2+) impermeable due to the expression of GluA2. However, the functional importance of AMPAR in microglia remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99a84b46036819999947d6ee6777ca16
https://doi.org/10.1002/glia.22481
https://doi.org/10.1002/glia.22481
Publikováno v:
Proceedings of the National Academy of Sciences. 109:20720-20725
Dynamic activity of glia has repeatedly been demonstrated, but if such activity is independent from neuronal activity, glia would not have any role in the information processing in the brain or in the generation of animal behavior. Evidence for neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21721dde008e5979f8e8895326a89045
https://doi.org/10.1073/pnas.1213458109
https://doi.org/10.1073/pnas.1213458109
Publikováno v:
Advances in Neuroimmune Biology. 1:53-62
Microglia, the immune cells of the central nervous system (CNS), are busy and vigilant housekeepers in the adult brain. The main candidate as a chemoattractant for microglia at damaged site is adenosine triphosphate (ATP). However, many other substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc7ea1b2a98731b3981df9c34c3a318
https://doi.org/10.3233/nib-2011-005
https://doi.org/10.3233/nib-2011-005