Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kaori Yuuki"'
Autor:
Yoshihiko Tomita, Tomoyuki Kato, Akira Nagaoka, Teiichi Motoyama, Andrey Ugolkov, Kaori Yuuki, Vladimir Bilim, Sei Naito
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df747c5b8ff8a2b6388bb1220d0f4f9
https://doi.org/10.1158/1078-0432.22442088.v1
https://doi.org/10.1158/1078-0432.22442088.v1
Autor:
Yoshihiko Tomita, Tomoyuki Kato, Akira Nagaoka, Teiichi Motoyama, Andrey Ugolkov, Kaori Yuuki, Vladimir Bilim, Sei Naito
Supplemental Figure 1. Immunohistochemical staining of GSK-3β in low (A-C) and high (D-F) grade urothelial tumors. Supplemental Figure 2. Hoechst staining of T24 cancer cells treated with 3 distinct small molecule inhibitors of GSK-3 (AR-A014418, SB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dd963d00ae2c104ad4d834bc765ac8
https://doi.org/10.1158/1078-0432.22442085.v1
https://doi.org/10.1158/1078-0432.22442085.v1
Autor:
Andrey Ugolkov, Akira Nagaoka, Yoshihiko Tomita, Sei Naito, Vladimir Bilim, Hisashi Kawazoe, Kaori Yuuki, Tomoyuki Kato
Publikováno v:
Biochemical and Biophysical Research Communications. 423:490-495
Sorafenib is a multikinase inhibitor approved for the systemic treatment of renal cell carcinoma (RCC). However, sorafenib treatment has a limited effect due to acquired chemoresistance of RCC. Previously, we identified glycogen synthase kinase-3 (GS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e281fa0dd0c244154854f65b4af57c38
https://doi.org/10.1016/j.bbrc.2012.05.147
https://doi.org/10.1016/j.bbrc.2012.05.147
Autor:
Kaori Yuuki, Andrey Ugolkov, Masaaki Tsukigi, Toshihiko Sakurai, Teiichi Motoyama, Vladimir Bilim, Yoshihiko Tomita
Publikováno v:
Biochemical and Biophysical Research Communications. 422(4):607-614
We investigated a prognostic significance and the mechanism of aberrant nuclear expression of EZH2, a histone methyltransferase, in human renal cell carcinoma (RCC). We found nuclear EZH2 in 48 of 100 RCCs and it was significantly correlated with wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427c47e4f7428ecd21ce077bd7fef2de
Autor:
Sei Naito, Yoshihiko Tomita, Vladimir Bilim, Kaori Yuuki, Tomoyuki Kato, Teiichi Motoyama, Andrey Ugolkov, Akira Nagaoka
Publikováno v:
Clinical Cancer Research. 16:5124-5132
Purpose: Although recent studies have shown glycogen synthase kinase-3β (GSK-3β), a serine/threonine kinase, as a positive regulator of pancreatic, colon, and kidney cancer cell survival and proliferation, the role of GSK-3 in bladder cancer remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee33a42c7075faa86560a80ced89cea2
https://doi.org/10.1158/1078-0432.ccr-10-0275
https://doi.org/10.1158/1078-0432.ccr-10-0275
Autor:
Yoshihiko Tomita, Daniel D. Billadeau, Hisashi Kawazoe, Akinori Muto, Vladimir Bilim, Sei Naito, Mototsugu Oya, Teiichi Motoyama, Kaori Yuuki, A. V. Ougolkov
Publikováno v:
British Journal of Cancer
Background: Renal cell carcinoma (RCC) is highly resistant to chemotherapy because of a high apoptotic threshold. Recent evidences suggest that GSK-3β positively regulates human pancreatic cancer and leukaemia cell survival in part through regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34acfcdc922d6222dba6eac160a54e1d
https://doi.org/10.1038/sj.bjc.6605437
https://doi.org/10.1038/sj.bjc.6605437
Autor:
Vladimir Bilim, Akinori Muto, Yoshihiko Tomita, Akira Nagaoka, Toshiyuki Itoi, Tomoyuki Kato, Teiichi Motoyama, Kaori Yuuki
Publikováno v:
British Journal of Cancer
Renal cell carcinoma (RCC) is known to be resistant to chemo- and radiotherapy due to a high apoptotic threshold. Smac and XIAP (X-linked inhibitor of apoptosis protein) proteins were detected in all RCC cell lines and tissue samples examined. We mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3df8b88aa18f6d0b682458f6390d4d
http://europepmc.org/articles/PMC2266840
http://europepmc.org/articles/PMC2266840
Autor:
Tomoyuki Kato, Sei Naito, Vladimir Bilim, Kaori Yuuki, Masaaki Tsukigi, Teiichi Motoyama, Akira Nagaoka, Andrey Ugolkov, Yoshihiko Tomita
Publikováno v:
Cancer letters. 315(2)
Recently, we have identified GSK-3 as a new therapeutic target in renal cell cancer (RCC). miR-199a could potentially downregulate GSK-3β expression. Here, we found a decreased miR-199a expression in 59% (32 of 54) of RCCs and it was correlated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48d184b77bf7a3eefab4803f7a05733
https://pubmed.ncbi.nlm.nih.gov/22093618
https://pubmed.ncbi.nlm.nih.gov/22093618
Autor:
Noriaki Hosoya, Tomoyuki Kato, Hisashi Kawazoe, Mototsugu Oya, Vladimir Bilim, Takahumi Narisawa, Masaaki Tsukigi, Toshihiko Sakurai, Teiichi Motoyama, Akira Nagaoka, Sei Naito, Kaori Yuuki, Yoshihiko Tomita, Andrey Ugolkov
Publikováno v:
Journal of Urology. 185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::755e52ba749ce2d5f4df6a61f9c54b16
https://doi.org/10.1016/j.juro.2011.02.183
https://doi.org/10.1016/j.juro.2011.02.183
Autor:
Tomoyuki, Kato, Vladimir, Bilim, Kaori, Yuuki, Sei, Naito, Takuya, Yamanobe, Akira, Nagaoka, Ikuya, Yano, Hideyuki, Akaza, Yoshihiko, Tomita
Publikováno v:
Anticancer research. 30(10)
Bacillus Calmette-Guerin (BCG) is one of therapeutic options for urothelial carcinoma (UC). The objectives of this study were to determine the direct effect of viable or heat-killed BCG and BCG cell wall skeleton (BCG-CWS) on UC cells in vitro.UC cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08a810c27808db90d9fed986330f95b5
https://pubmed.ncbi.nlm.nih.gov/21036724
https://pubmed.ncbi.nlm.nih.gov/21036724