Extensive HLA class I allele promiscuity among viral CTL epitopes

Autor: John Sidney, Tonia Woodberry, Nicole Frahm, Kaori Sango, Simon Mallal, Eunice Pae, Florian Bihl, Carl M. Kadie, Nebojsa Jojic, Bruce D. Walker, Karina Yusim, Todd J. Suscovich, Alessandro Sette, Peter T. Hraber, Kellie Faircloth, Ashok Khatri, Francesco M. Marincola, Sharon Adams, Daniel G. Kavanagh, Hannah S. Hewitt, Caitlyn Linde, Jennifer Listgarten, Mina John, Christian Brander, Leah M. Henry, M. Tauheed Zaman, Bette T. Korber, Nancy V. Brown, David Heckerman

Publikováno v: European Journal of Immunology. 37:2419-2433

Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3976035b4412908691a01c52a263159d
https://doi.org/10.1002/eji.200737365

Novel Mouse Models for Understanding HIV-1 Pathogenesis

Autor: Harris Goldstein, Kaori Sango, Aviva Joseph

Publikováno v: Methods in Molecular Biology ISBN: 9781588298591

Small animal models in which in vivo HIV-1 infection, pathogenesis, and immune responses can be studied would permit both basic research on the biology of the disease, as well as a system to rapidly screen developmental therapeutics and/or vaccines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afb170c53e7359c8223396aefc10c914
https://doi.org/10.1007/978-1-59745-170-3_21

Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity

Autor: Antonia Follenzi, Jian Hua Zheng, Ken Chen, Jaime Hyman, Teresa P. DiLorenzo, Christian Brander, Erik Hooijberg, Alicja Piechocka-Trocha, Bruce D. Walker, Harris Goldstein, Dario A. A. Vignali, Aviva Joseph, Kaori Sango

Publikováno v: Journal of Virology, 82(6), 3078-3089. American Society for Microbiology
Joseph, A, Zheng, J H, Follenzi, A, Dilorenzo, T, Sango, K, Hyman, J, Chen, K, Piechocka-Trocha, A, Brander, C, Hooijberg, E, Vignali, D A, Walker, B D & Goldstein, H 2008, ' Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity ', Journal of Virology, vol. 82, no. 6, pp. 3078-3089 . https://doi.org/10.1128/JVI.01812-07

The human immunodeficiency virus type 1 (HIV-1)-specific CD8 cytotoxic T-lymphocyte (CTL) response plays a critical role in controlling HIV-1 replication. Augmenting this response should enhance control of HIV-1 replication and stabilize or improve t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38bab610873b99caec99a577209c8a6
https://research.vumc.nl/en/publications/ce2a199e-c1f1-4590-b2e3-7bcd18dffdf6

HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load

Autor: Timothy Roach, Alysse G. Wurcel, Philip J. R. Goulder, Bruce D. Walker, Francesco M. Marincola, Eunice Pae, Kaori Sango, Todd M. Allen, Margaret E. Feeney, Christian Brander, Mathias Lichterfeld, Marcus Altfeld, Caitlyn Linde, Photini Kiepiela, Nicole Frahm, Hannah S. Hewitt, M. Anne St. John, Eric S. Daar, Eric S. Rosenberg, Bette T. Korber, Nancy V. Brown, Sharon Adams

Publikováno v: Journal of virology. 79(16)

Several HLA class I alleles have been associated with slow human immunodeficiency virus (HIV) disease progression, supporting the important role HLA class I-restricted cytotoxic T lymphocytes (CTL) play in controlling HIV infection. HLA-B63, the sero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8068c66360333959b90c5def16544e
https://pubmed.ncbi.nlm.nih.gov/16051815

Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells

Autor: Nithianandan Selliah, Richard P. Junghans, Gautam K. Sahu, Kaori Sango, Qiangzhong Ma, Gail Skowron

Publikováno v: Virology. (1-2):268-275

The current antiretroviral therapy (ART) can effectively reduce plasma HIV loads to undetectable levels, but cannot eliminate latently infected resting memory CD4 T cells that persist for the lifetime of infected patients. Therefore, designing new th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2086c90088270b952f6bedce6c670da9