Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kaori Noridomi"'
Publikováno v:
eLife, Vol 6 (2017)
The nicotinic acetylcholine receptor (nAChR) is a major target of autoantibodies in myasthenia gravis (MG), an autoimmune disease that causes neuromuscular transmission dysfunction. Despite decades of research, the molecular mechanisms underlying MG
Externí odkaz:
https://doaj.org/article/dc254552d6ad4deabb5fc342005a6464
Autor:
Lin Chen, Christopher R. Hughes, Henry A. Lester, Ronald J. Lukas, Aaron L. Nichols, Gaurav Advani, J. Brek Eaton, Kaori Noridomi, Richard W. Roberts, Farzad Jalali-Yazdi, Lan Huong Lai
Publikováno v:
ACS Chem Biol
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that play a central role in neuronal and neuromuscular signal transduction. Here, we have developed FANG ligands, fibronectin antibody-mimetic nicotinic acetylcholine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02d0b2ee1d50f827a1c6fd92e3c7f06
https://doi.org/10.1021/acschembio.8b00513
https://doi.org/10.1021/acschembio.8b00513
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
The nicotinic acetylcholine receptor (nAChR) is a major target of autoantibodies in myasthenia gravis (MG), an autoimmune disease that causes neuromuscular transmission dysfunction. Despite decades of research, the molecular mechanisms underlying MG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2cca2e0f02a30ab596627b8da5c658
https://elifesciences.org/articles/23043
https://elifesciences.org/articles/23043
Autor:
Jun Ye, Tao Gao, Ju He, Michael A. Philips, Raja Dey, Jamie Jarusiewicz, Kevin J. Gaffney, Aidong Han, Lin Chen, Xiao Lei, Kaori Noridomi, Nicos A. Petasis, Nimanthi Jayathilaka
Publikováno v:
Nucleic Acids Research
Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e971092b8ed33e92ac3c2cbacab73d
http://europepmc.org/articles/PMC3384312
http://europepmc.org/articles/PMC3384312
Autor:
Sun Huang, Steven M. Sine, Cosma D. Dellisanti, Nina Bren, Kaori Noridomi, Lin Chen, Shu Xing Li
Publikováno v:
Nature Neuroscience. 14:1253-1259
The authors determine the crystal structure of the extracellular domain of a receptor chimera constructed from the human α7 acetylcholine receptor (AChR) and acetylcholine binding protein (AChBP), as well as the structure with bound epibatidine, a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9812660d981d958ba638866d329aa0
https://doi.org/10.1038/nn.2908
https://doi.org/10.1038/nn.2908
Publikováno v:
Biochemical Pharmacology. 97:627
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a075ba896cfe04894c51f46eb5d6b2f
https://doi.org/10.1016/j.bcp.2015.08.020
https://doi.org/10.1016/j.bcp.2015.08.020