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Akademický článek

Case Report: MYH9-related disease caused by Ala44Pro mutation in a child with a previous diagnosis of chronic immune thrombocytopenia

Autor: Kaori Niwa, Hidemi Toyoda, Atsushi Kohso, Yosuke Okumura, Shinji Kunishima, Masahiro Hirayama

Publikováno v: Frontiers in Pediatrics, Vol 12 (2024)

MYH9-related disease, a rare autosomal dominant platelet disorder characterized by thrombocytopenia, giant platelets, and leukocyte inclusion bodies, may mimic immune thrombocytopenia in children unless suspected and carefully excluded. Here, we pres

Externí odkaz: https://doaj.org/article/69ef46d68e51463bb9d702afdf78d67e

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Akademický článek

Improved Antitumor Effect of NK Cells Activated by Neutrophils in a Bone Marrow Transplant Model

Autor: Daisuke Nakato, Shotaro Iwamoto, Keishiro Amano, Takahiro Ito, Hidemi Toyoda, Ryo Hanaki, Mari Morimoto, Kaori Niwa, Isao Tawara, Kyoko Imanaka-Yoshida, Masahiro Ogawa, Masahiro Hirayama

Publikováno v: Mediators of Inflammation, Vol 2023 (2023)

The licensing process mediated by inhibitory receptors of the Ly49 C-type lectin superfamily that recognizes self-major histocompatibility complex (MHC) class I in mice is essential for the proper antitumor function of natural killer (NK) cells. Seve

Externí odkaz: https://doaj.org/article/20b9b5d21a3845a0a85a3b857a70aec6

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Akademický článek

Donor‐derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation

Autor: Ryo Hanaki, Hidemi Toyoda, Shotaro Iwamoto, Mari Morimoto, Daisuke Nakato, Takahiro Ito, Kaori Niwa, Keishiro Amano, Ryotaro Hashizume, Isao Tawara, Masahiro Hirayama

Publikováno v: Immunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1489-1499 (2021)

Abstract Introduction Graft‐versus‐host disease (GVHD) is frequent and fatal complication following allogeneic hematopoietic stem cell transplantation (HSCT) and characteristically involves skin, gut, and liver. Macrophages promote tissue regener

Externí odkaz: https://doaj.org/article/4ca97194d62e4f2aae0ccf11a866334a

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Akademický článek

Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.

Autor: Kenshiro Tsuda, Keiichi Yamanaka, Hiroshi Kitagawa, Tomoko Akeda, Masanao Naka, Kaori Niwa, Takehisa Nakanishi, Masato Kakeda, Esteban C Gabazza, Hitoshi Mizutani

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31465 (2012)

T cells have been classified as belonging to the Th1 or Th2 subsets according to the production of defining cytokines such as IFN-γ and IL-4. The discovery of the Th17 lineage and regulatory T cells shifted the simple concept of the Th1/Th2 balance

Externí odkaz: https://doaj.org/article/744027cbc2f84e069f916c82b6176df4

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Donor‐derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation

Autor: Daisuke Nakato, Mari Morimoto, Kaori Niwa, Shotaro Iwamoto, Isao Tawara, Keishiro Amano, Hidemi Toyoda, Masahiro Hirayama, Ryotaro Hashizume, Takahiro Ito, Ryo Hanaki

Publikováno v: Immunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1489-1499 (2021)
Immunity, Inflammation and Disease

Introduction Graft‐versus‐host disease (GVHD) is frequent and fatal complication following allogeneic hematopoietic stem cell transplantation (HSCT) and characteristically involves skin, gut, and liver. Macrophages promote tissue regeneration and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d675cfa10ab700985189ebd42781d90
https://doaj.org/article/4ca97194d62e4f2aae0ccf11a866334a

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Nafamostat mesylate prevents metastasis and dissemination of neuroblastoma through vascular endothelial growth factor inhibition

Autor: Mari, Morimoto, Hidemi, Toyoda, Kaori, Niwa, Ryo, Hanaki, Taro, Okuda, Daisuke, Nakato, Keishiro, Amano, Shotaro, Iwamoto, Masahiro, Hirayama

Publikováno v: Molecular and Clinical Oncology. 17

Neuroblastoma is a highly malignant disease with a poor prognosis and few treatment options. Despite conventional chemotherapy for neuroblastoma, resistance, invasiveness, and metastatic mobility limit the treatment efficacy. Therefore, it is necessa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35357281eb0efcfbbaee720243a87e7d
https://doi.org/10.3892/mco.2022.2571

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High-resolution mapping of zym, a recessive gene for Zucchini yellow mosaic virus resistance in cucumber

Autor: Kaori Niwa, Akira Mochizuki, Masashi Amano, Takanori Maeda, Yoshiyuki Imura, Keisuke Iwahori, Jiri Svoboda, Yumi Kawagoe

Publikováno v: Theoretical and Applied Genetics. 126:2983-2993

Using a high-resolution mapping approach, we identified a candidate gene for ZYMV resistance in cucumber. Our findings should assist the development of high-versatility molecular markers for MAS for ZYMV resistance. Zucchini yellow mosaic virus (ZYMV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae180648d4c16a46ebb82ed55dd5f54a
https://doi.org/10.1007/s00122-013-2187-5

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