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of 8
pro vyhledávání: '"Kaori Nakamoto"'
Publikováno v:
Pharmacogenetics and Genomics. 18:11-24
Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons to all microsomal P450 enzymes, which catalyze the biosynthesis of steroids, fatty acids, and bile acids, as well as metabolism of more than 80% of prescription drug
Autor:
Xiao-bo Zhong, Kenneth K. Kidd, Kaori Nakamoto, Robert D. Jenison, Curtis D. Klaassen, Yu-Jui Yvonne Wan, Judith R. Kidd
Publikováno v:
Pharmacogenetics and Genomics. 17:103-114
Numerous functional polymorphisms in the CYP2C19 gene have been identified; some alleles (e.g. CYP2C19*2 and CYP2C19*3) are associated with poor metabolism of CYP2C19 substrate drugs. Studies have found that the proportion of poor metabolizers, expla
Publikováno v:
Drug Metabolism and Pharmacokinetics. 22:322-326
Summary: Cytochrome P450 oxidoreductase (POR) is the single flavoprotein which donates electrons to the microsomal cytochrome P450 enzymes for oxidation of their substrates. In this study, we sequenced all 15 exons and the surrounding intronic sequen
Autor:
Kaori Nakamoto
Publikováno v:
HISPANICA / HISPÁNICA. 2002:98-111
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(6)
HepaRG cells, derived from a female hepatocarcinoma patient, are capable of differentiating into biliary epithelial cells and hepatocytes. More importantly, differentiated HepaRG cells are able to maintain activities of many xenobiotic-metabolizing e
Publikováno v:
The FASEB Journal. 22
Autor:
David B. Buckley, Xiao-bo Zhong, Curtis D. Klaassen, Kaori Nakamoto, Steven N. Hart, Shuang Wang, Ye Li
Publikováno v:
The FASEB Journal. 22
Autor:
Shuang Wang, Grace L. Guo, Curtis D. Klaassen, Robert D. Jenison, Xiao-bo Zhong, Yu-Jui Yvonne Wan, Kaori Nakamoto
Publikováno v:
BMC Genetics, Vol 7, Iss 1, p 29 (2006)
BMC genetics, vol 7, iss 1
BMC Genetics
BMC genetics, vol 7, iss 1
BMC Genetics
BackgroundCholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol and bile acids, including hy