Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kaori Igarashi"'
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101531- (2022)
Summary: Capillary electrophoresis mass spectrometry (CE-MS) can measure the intracellular amount of highly polar and charged metabolites; liquid chromatography mass spectrometry (LC-MS) can quantify hydrophobic metabolites. A comprehensive metabolom
Externí odkaz:
https://doaj.org/article/c6fb5a7ce424436cbf059c205c84e541
Autor:
Julie Adam, Reshma Ramracheya, Margarita V. Chibalina, Nicola Ternette, Alexander Hamilton, Andrei I. Tarasov, Quan Zhang, Eduardo Rebelato, Nils J.G. Rorsman, Rafael Martín-del-Río, Amy Lewis, Gizem Özkan, Hyun Woong Do, Peter Spégel, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Benedikt M. Kessler, Christopher W. Pugh, Jorge Tamarit-Rodriguez, Hindrik Mulder, Anne Clark, Norma Frizzell, Tomoyoshi Soga, Frances M. Ashcroft, Andrew Silver, Patrick J. Pollard, Patrik Rorsman
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3135-3148 (2017)
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6–8 weeks but then develop progressive glucose intoleran
Externí odkaz:
https://doaj.org/article/05d52d7c48f340449106e32e0dd4ebf7
Autor:
Tsuyoshi Osawa, Teppei Shimamura, Kyoko Saito, Yoko Hasegawa, Naoko Ishii, Miyuki Nishida, Ritsuko Ando, Ayano Kondo, Muyassar Anwar, Rika Tsuchida, Shinjiro Hino, Akihisa Sakamoto, Kaori Igarashi, Kaori Saitoh, Keiko Kato, Keiko Endo, Shotaro Yamano, Yasuharu Kanki, Yoshihiro Matsumura, Takashi Minami, Toshiya Tanaka, Motonobu Anai, Youichiro Wada, Hideki Wanibuchi, Mitsuhiro Hayashi, Akinobu Hamada, Masayuki Yoshida, Shinichi Yachida, Mitsuyoshi Nakao, Juro Sakai, Hiroyuki Aburatani, Masabumi Shibuya, Kentaro Hanada, Satoru Miyano, Tomoyoshi Soga, Tatsuhiko Kodama
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 89-103.e7 (2019)
Summary: Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a common feature of aggressive cancer cells and can be targeted. However, metabolic alterations that support cancer cells upon nutrient starvation are
Externí odkaz:
https://doaj.org/article/c34c33e130784dc786b3ca3e8ed731d1
Autor:
Julie Adam, Ming Yang, Christina Bauerschmidt, Mitsuhiro Kitagawa, Linda O’Flaherty, Pratheesh Maheswaran, Gizem Özkan, Natasha Sahgal, Dilair Baban, Keiko Kato, Kaori Saito, Keiko Iino, Kaori Igarashi, Michael Stratford, Christopher Pugh, Daniel A. Tennant, Christian Ludwig, Benjamin Davies, Peter J. Ratcliffe, Mona El-Bahrawy, Houman Ashrafian, Tomoyoshi Soga, Patrick J. Pollard
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1440-1448 (2013)
The identification of mutated metabolic enzymes in hereditary cancer syndromes has established a direct link between metabolic dysregulation and cancer. Mutations in the Krebs cycle enzyme, fumarate hydratase (FH), predispose affected individuals to
Externí odkaz:
https://doaj.org/article/36f1008b51414a3d9cf692eec868d7c8
Autor:
Nicola Ternette, Ming Yang, Mahima Laroyia, Mitsuhiro Kitagawa, Linda O’Flaherty, Kathryn Wolhulter, Kaori Igarashi, Kaori Saito, Keiko Kato, Roman Fischer, Alexandre Berquand, Benedikt M. Kessler, Terry Lappin, Norma Frizzell, Tomoyoshi Soga, Julie Adam, Patrick J. Pollard
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 689-700 (2013)
The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity causes accumulation of intracellular fumarate, which can directly modify cysteine residues to
Externí odkaz:
https://doaj.org/article/dd77064ebe1648f7a88f44f3b46d35fb
Autor:
Tomohiro Suzuki, Kaori Igarashi, Hideo Dohra, Takumi Someya, Tomoyuki Takano, Kiyonori Harada, Saori Omae, Hirofumi Hirai, Kentaro Yano, Hirokazu Kawagishi
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69681 (2013)
BACKGROUND: Pleurocybellaporrigens is a mushroom-forming fungus, which has been consumed as a traditional food in Japan. In 2004, 55 people were poisoned by eating the mushroom and 17 people among them died of acute encephalopathy. Since then, the Ja
Externí odkaz:
https://doaj.org/article/8b2533ad38d2416888792b9aff9bfa3e
Autor:
Sho Tabata, Yasushi Kojima, Takeharu Sakamoto, Kaori Igarashi, Ko Umetsu, Takamasa Ishikawa, Akiyoshi Hirayama, Rie Kajino-Sakamoto, Naoya Sakamoto, Ken-ichi Yasumoto, Keiichi Okano, Yasuyuki Suzuki, Shinichi Yachida, Masahiro Aoki, Tomoyoshi Soga
Publikováno v:
Oncogene. 42:1294-1307
Oncometabolites, such as D/L-2-hydroxyglutarate (2HG), have directly been implicated in carcinogenesis; however, the underlying molecular mechanisms remain poorly understood. Here, we showed that the levels of the L-enantiomer of 2HG (L2HG) were spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82dbafc82bee65cdd7bb42b7543c6cc4
https://doi.org/10.1038/s41388-023-02632-7
https://doi.org/10.1038/s41388-023-02632-7
Autor:
Hiroki Kuroda, Tomoyoshi Soga, Sanae Ashitani, Yusuke Hara, Atsushi Shinjo, Kaori Igarashi, Keiko Endo, Ayaka Sugawara, Kosuke Cris Yamada
Publikováno v:
Nippon Shokuhin Kagaku Kogaku Kaishi. 67:499-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aea0da0b6d5963000d33ef638f4bb8c7
https://doi.org/10.3136/nskkk.67.499
https://doi.org/10.3136/nskkk.67.499
Autor:
Keisuke Yamamoto, Y. Nakai, Kazuhiko Koike, Keisuke Tateishi, Yoku Hayakawa, Kento Misumi, Hiroaki Fujiwara, Takuma Nakatsuka, Hiroyuki Isayama, Hideaki Ijichi, Nobumi Suzuki, Hayato Nakagawa, Yotaro Kudo, Akimasa Hayashi, Hirofumi Kogure, Hiroyuki S. Kato, Kiyoshi Hasegawa, Yasuo Tanaka, Masashi Fukayama, Tomoyoshi Soga, Kaori Igarashi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Metabolism is a critical regulator of cell fate determination. Recently, the significance of metabolic reprogramming in environmental adaptation during tumorigenesis has attracted much attention in cancer research. Recurrent mutations in the isocitra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8748b23bba5f7e70b16903701108e5e
http://link.springer.com/article/10.1038/s41598-019-55211-w
http://link.springer.com/article/10.1038/s41598-019-55211-w
Autor:
Hokuto Nakayama, Michitaka Notaguchi, Atsushi J. Nagano, Masaki Yasugi, Kaori Igarashi, Kentaro Yano, Kaori Kaminoyama, Nakao Kubo, Yaichi Kawakatsu, Hiroshi Kudoh, Tomoaki Sakamoto, Seisuke Kimura
Publikováno v:
Horticulture Research
Since ancient times, humans have bred several plants that we rely on today. However, little is known about the divergence of most of these plants. In the present study, we investigated the divergence of Mibuna (Brassica rapa L. subsp. nipposinica L.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6753132f5d797ba636a561144e70256c
http://europepmc.org/articles/PMC8167115
http://europepmc.org/articles/PMC8167115