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Autor:
Udit Kumar Chakraborty, Peng Chen, Chunming Liu, Geoffrey W. Coates, Susil Baral, Kaori Kubo, Xianwen Mao
Publikováno v:
Chem. 7:2175-2189
Summary Conjugated polymers possess unique optoelectrical properties. Characterizing their synthesis and mechanical processability is crucial for tailored applications. Their poor solubility presents a universal challenge, however. Here, we report a
Autor:
Yuka Kawato, Hidehiko Fukahori, Koji Nakamura, Kaori Kubo, Masaki Hiramitsu, Fumitaka Kinugasa, Tatsuaki Morokata
Publikováno v:
European journal of pharmacology. 938
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multi-organ systems with a widely heterogeneous clinical presentation. Renal involvement, observed mainly in lupus nephritis (LN), is the most common organ lesion associated with S
Autor:
Yuka, Kawato, Hidehiko, Fukahori, Koji, Nakamura, Atsuo, Kanno, Kaori, Kubo, Masaki, Hiramitsu, Toshihiro, Matsuda, Yuichi, Hanada, Takako, Furukawa, Yutaka, Nakajima, Fumitaka, Kinugasa, Tatsuaki, Morokata
Publikováno v:
European Journal of Pharmacology. 919:174826
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the dysregulation of various cell types and immunological pathways. Autoantibodies play an important role in its pathogenesis. The presence of autoantibodies suggests that s
Autor:
Takuya Kamio, Kenichi Yoshida, Tomohiko Sato, Ko Kudo, Tsutomu Toki, Etsuro Ito, Kaori Kubo, Yusuke Shiozawa, Shinya Sasaki, Seishi Ogawa, Kiminori Terui, Rika Kanezaki, Akie Kobayashi, Akira Kurose, Hiroo Ueno
Publikováno v:
Genes, Chromosomes and Cancer. 57:665-669
The authors report two siblings with familial neuroblastoma with a germline R1275Q mutation of the tyrosine kinase domain of ALK. Whole exome sequencing and copy number variation assay were performed to investigate genetic alterations in the two case
Autor:
Takahisa Noto, Yuka Kawato, Kaori Kubo, Tatsuaki Morokata, Yoko Kaneko, Hidehiko Fukahori, Tomonori Nakanishi, Masamichi Inami, Misato Ito, Masashi Maeda, Jun Hirose, Kaori Hanaoka, Koji Nakamura
Publikováno v:
Transplant Immunology. 46:14-20
Background Janus kinase (JAK) inhibitors are thought to be promising candidates to aid renal transplantation. However, the effectiveness of JAK inhibitors against features of chronic rejection, including interstitial fibrosis/tubular atrophy (IF/TA)
Autor:
Chunming Liu1, Kaori Kubo1, Endian Wang2, Kyu-Sung Han1, Feng Yang1, Guanqun Chen1, Escobedo, Fernando A.2 fe13@cornell.edu, Coates, Geoffrey W.1 coates@cornell.edu, Peng Chen1 pc252@cornell.edu
Publikováno v:
Science. 10/20/2017, Vol. 358 Issue 6361, p352-355. 4p. 1 Color Photograph, 3 Diagrams.
Autor:
Junichi Mineno, Toshikazu Nishie, Sachiko Okamoto, Koji Nagaoka, Jun Nakajima, Kazuhiro Kakimi, Yukari Kobayashi, Kaori Kubo, Shunji Takahashi, Yasuyoshi Sato, Tatsuji Enoki
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A71-A71
BackgroundT-cells that target tumor neoantigens arising from cancer mutations are the primary mediators of cancer immunotherapies. Identifying neoantigens and T-cells that recognize them is essential for T-cell-based immunotherapy. However, neoantige
Autor:
Akiyoshi Fukamizu, Shota Okamuro, Tsuyoshi Waku, Hiroaki Taniguchi, Kaori Kubo, Akira Kobayashi, Atsushi Hatanaka, Yimeng Sun, Misaki Koji, A.M. Masudul Azad Chowdhury
Publikováno v:
Biochemical and Biophysical Research Communications. 484:176-183
The transcription factor Nrf1 (NFE2L1) maintains protein homeostasis (proteostasis) by regulating the gene expression of proteasome subunits in response to proteasome inhibition. The deletion of the Nrf1 gene in neural stem/progenitor cells causes se
Autor:
Kaori Hanaoka, Hidehiko Fukahori, Yasuyuki Higashi, Masamichi Inami, Yuka Kawato, Terry Y. Nakagawa, Shinsuke Oshima, Koji Nakamura, Tatsuaki Morokata, Yutaka Nakajima, Kaori Kubo
Publikováno v:
European journal of pharmacology. 838
Donor-specific antibodies (DSA) are a major risk factor for antibody-mediated rejection (ABMR) in solid organ transplantation, and ABMR remains a medical challenge. Therefore, effective anti-ABMR therapies are needed to improve overall graft survival