Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kanzo Kimura"'
Autor:
Kanzo Kimura, Tetsuya Shigeta, Harumi Namiki, Yoshitaka Ino, Sachio Kawasaki, Yasuhide Kitazaki, Katsutoshi Inaba, Sumi Imada
Publikováno v:
The Quality Assurance Journal. 11:44-52
In Japan, many test facilities have been inspected by the monitoring agency since 1984 and inspectors pointed out some issues for improvement. The interest in test article analyses in support of Good Laboratory Practice (GLP)-compliant studies has be
Autor:
Eiji Takahara, Taisei Mushiroda, Kanzo Kimura, Osamu Nagata, Tetsuya Kamataki, Hideo Kato, Noritaka Ariyoshi
Publikováno v:
Biochemical and Biophysical Research Communications. 269:393-396
Northern blot analysis of mRNA prepared from the lung of Suncus murinus (suncus), which was classified as an ancestor of primates, revealed that the expression level of cytochrome P450 2A (CYP2A) mRNA was about 100-fold higher than in the lung from r
Autor:
Yuki Takahashi, Masami Miyamoto, Kanzo Kimura, Yuri Umetsu, Satoshi Daigo, Noritaka Ariyoshi, Philippe Beaune, Tetsuya Kamataki, Tsuyoshi Yokoi, Ken-ichi Nunoya
Publikováno v:
Drug Metabolism and Pharmacokinetics. 15:57-61
CYP2A6 has been characterized as a coumarin 7-hydroxylase in humans. A large interindividual difference in the activity of coumarin 7-hydroxylation suggested an existence of genetic polymorphism of this enzyme. In fact, CYP2A6*2 variant allele which
Publikováno v:
Xenobiotica. 25:1283-1291
1. Rat hepatic flavin-containing monooxygenase 1 (FMO1) expressed in yeast catalyzed the S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) in vitro. 2. S-oxidation was inhibited by 1-(1-naphthyl)-2-thiourea a
Autor:
Kanzo Kimura, Carol E. Green, Kazuo Nagashima, Tsuyoshi Yokoi, Moritoshi Kinoshita, Ken ichi Nunoya, Yoshihiko Funae, Takao Kodama, Masato Funayama, Kazuaki Inoue, Tetsuya Kamataki
Publikováno v:
Pharmacogenetics. 8(3)
The S-oxidation of (4)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) and the 7-hydroxylation of coumarin are primarily catalyzed by cytochrome P450 2A6 (CYP2A6). The activities of SM-12502 S-oxidase and coumarin 7-hydroxyla
Autor:
Jun-Tack Kwon, Fred F. Kadlubar, Philippe Beaune, Yuki Takahashi, Tetsuya Kamataki, Satoshi Daigo, Rashimi Shinha, Noritaka Ariyoshi, Tsuyoshi Yokoi, Ken-ichi Nunoya, Masami Miyamoto, Kanzo Kimura, Yuri Umetsu
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:100-101
CYP2A6 is known as an enzyme responsible for the metabolism of coumarin. As its toxicological significance, aflatoxin B1 and NNK are metabolically activated by this CYP to mutagens. In our recent studies, we found that a newly developed drug, SM-1250
Autor:
Kanzo Kimura, Setsuko Komuro, Akira Yoshitake, Iwao Nakatsuka, Masaki Ito, Yoshiko Mizuno, Koichi Sugihara, Humiaki Shono, Yoshitaka Ohbe
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:91-111
The metabolism of (−)-(2S, 3R)-2-amino-3-hydroxy-3-(3, 4-dihydroxyphenyl) propionic acid (L-DOPS), an unphysiological amino acid and the precursor of (−)-norepinephrin (NE) was investigated in mice, rats, dogs and Rhesus monkeys after oral admini
Publikováno v:
Drug Metabolism and Pharmacokinetics. 4:63-81
The absorption, distribution and excretion of ethan-l-hydroxy-1, 1-diphosphonate (EHDP, SM-5600) were investigated in mice, rats and dogs after single oral or intravenous administration of 14C-SM-5600.1. When 14C-SM-5600 was orally administered (50 m
Autor:
Kanzo Kimura, Setsuko Komuro, Humiaki Shono, Yoshiko Mizuno, Akira Yoshitake, Yoshitaka Ohbe, Iwao Nakatsuka, Masaki Ito, Koichi Sugihara
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:53-70
The absorption, distribution and excretion of (−)-(2 S, 3 R)-2-amino-3-hydroxy-3-(3, 4-dihydroxyphenyl) propionic acid (L-DOPS), an unphysiological amino acid and the precursor of norepinephrine, were investigated in mice, rats, dogs and Rhesus mon
Autor:
Koichi Sugihara, Iwao Nakatsuka, Humiaki Shono, Masaki Ito, Yoshiko Mizuno, Kanzo Kimura, Akira Yoshitake
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:519-529
1. After a single oral administration of 14C-L-DOPS (10 mg/kg), substantially no differences in serum 14C levels, 14C excretion and urinary excretion rates of motabolites were found between aged (53 weeks old) and young adult (7 weeks old) rats. 2. A