Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kanta Kon"'
Autor:
Hiroshi Tsuneki, Takahiro Maeda, Shinjiro Takata, Masanori Sugiyama, Koyuki Otsuka, Hinako Ishizuka, Yasuhiro Onogi, Emi Tokai, Chiaki Koshida, Kanta Kon, Ichiro Takasaki, Takeru Hamashima, Masakiyo Sasahara, Assaf Rudich, Daisuke Koya, Takeshi Sakurai, Masashi Yanagisawa, Akihiro Yamanaka, Tsutomu Wada, Toshiyasu Sasaoka
Publikováno v:
Cell Reports. 41:111497
Non-alcoholic steatohepatitis (NASH) occasionally occurs under obesity; however, factors modulating the natural history of fatty liver disease remain unknown. Since hypothalamic orexin that regulates physical activity and autonomic balance prevents o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349139e13eef6d481ac6ad0aa4c208eb
https://doi.org/10.1016/j.celrep.2022.111497
https://doi.org/10.1016/j.celrep.2022.111497
Autor:
Zydrune, Polianskyte-Prause, Tuomas A, Tolvanen, Sonja, Lindfors, Kanta, Kon, Laura C, Hautala, Hong, Wang, Tsutomu, Wada, Hiroshi, Tsuneki, Toshiyasu, Sasaoka, Sanna, Lehtonen
Publikováno v:
International journal of biological sciences. 18(5)
Ebselen, a multifunctional organoselenium compound, has been recognized as a potential treatment for diabetes-related disorders. However, the underlying mechanisms whereby ebselen regulates metabolic pathways remain elusive. We discovered that ebsele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::851cb6792e3401caf42cf10b7be2a31e
https://pubmed.ncbi.nlm.nih.gov/35342343
https://pubmed.ncbi.nlm.nih.gov/35342343
Autor:
Oleg Dukhno, Hiroshi Tsuneki, Toshiyasu Sasaoka, Yftach Gepner, Boris Kirshtein, Yulia Haim, Tsutomu Wada, Idit F. Liberty, Nitzan Maixner, Assaf Rudich, Eleonora Aimaretti, Nir Goldstein, Nikhil S. Bhandarkar, Kanta Kon, Kiyofumi Sato
Publikováno v:
Obesity (Silver Spring, Md.)REFERENCES. 29(11)
OBJECTIVE Orexin/hypocretin (Ox) and its receptors (OxR), a neuroendocrine system centrally regulating sleep/wakefulness, were implicated in the regulation of peripheral metabolism. It was hypothesized that human adipose tissue constitutes a direct t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9497c6e79a804a9ed45cef01c73062ac
https://pubmed.ncbi.nlm.nih.gov/34472713
https://pubmed.ncbi.nlm.nih.gov/34472713
Autor:
Wolfgang F. Graier, Tobias Pendl, Dagmar Kratky, Dina Hofer, Renate Schreiber, Wael Al Zoughbi, Kyosuke Uno, Masakiyo Sasahara, Hiroshi Tsuneki, Gabriele Schoiswohl, Kanta Kon, Toshiyasu Sasaoka, Toh Miyazaki, Johan Auwerx, Katharina Huber, Tobias Eisenberg, Juliane G. Bogner-Strauss, Gabriel Zirkovits, Ariane Pessentheiner, Corina T. Madreiter-Sokolowski, Wenmin Xia, Matthias Eckhardt, Gerald Hoefler, Atsumi Nitta, Christoph Magnes, Gert Trausinger, Simon Sedej, Helmut Josef Pelzmann, Mahmoud Abdellatif
Publikováno v:
The FASEB Journal
N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl–coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1480ca65a22739c70493457b045177
https://doi.org/10.1096/fj.201801323r
https://doi.org/10.1096/fj.201801323r
Hypothalamic orexin prevents obesity and non-alcoholic fatty liver disease in mice fed high fat diet
Autor:
Chiaki Koshida, Takahiro Maeda, Hiroshi Tsuneki, Shinjiro Takata, Tsutomu Wada, Toshiyasu Sasaoka, Kanta Kon
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO2-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c54b4542bd9b938899642b77fb55bb
https://doi.org/10.1254/jpssuppl.wcp2018.0_po2-7-35
https://doi.org/10.1254/jpssuppl.wcp2018.0_po2-7-35
Autor:
Tsutomu Wada, Kanta Kon, Hisakatsu Ito, Toshiyasu Sasaoka, Masakiyo Sasahara, Hiroshi Tsuneki, Kiyofumi Sato, Yoshinori Takemura, Yoko Ishii, Takahiro Maeda, Mitsuaki Yamazaki, Assaf Rudich
Publikováno v:
The Journal of endocrinology.
Disrupted sleep is associated with increased risk of type 2 diabetes. Central actions of orexin, mediated by orexin-1 and orexin-2 receptors, play a crucial role in the maintenance of wakefulness; accordingly, excessive activation of the orexin syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114402f006c1a0993f79be51fc598702
https://pubmed.ncbi.nlm.nih.gov/31394498
https://pubmed.ncbi.nlm.nih.gov/31394498
Autor:
Hisakatsu Ito, Mitsuaki Yamazaki, Satoyuki Takahara, Toshiyasu Sasaoka, Yoko Ishii, Masakiyo Sasahara, Kanta Kon, Hiroshi Tsuneki, Naoki Toyooka, Masashi Yanagisawa, Takeshi Sakurai, Tsutomu Wada
Publikováno v:
Endocrinology. 157:4146-4157
Sleep disturbances are associated with type 2 diabetes; therefore, the amelioration of sleep may improve metabolic disorders. To investigate this possibility, we here examined the effects of suvorexant, an antiinsomnia drug targeting the orexin syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712620149bf790a216a4e13437823c00
https://doi.org/10.1210/en.2016-1404
https://doi.org/10.1210/en.2016-1404
Autor:
Mikio Fujita, Kaoru Yamaguchi, Hisao Nishijo, Takashi Nagata, Toshiyasu Sasaoka, Naizhen Wu, Hiroshi Tsuneki, Takeshi Sakurai, Tsutomu Wada, Mayumi Takatsuki, Masashi Yanagisawa, Kanta Kon
Publikováno v:
Endocrinology. 157:195-206
Nicotine is known to affect the metabolism of glucose; however, the underlying mechanism remains unclear. Therefore, we here investigated whether nicotine promoted the central regulation of glucose metabolism, which is closely linked to the circadian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c06e54387f7172e0eafad4809d318d
https://doi.org/10.1210/en.2015-1488
https://doi.org/10.1210/en.2015-1488
Publikováno v:
Diabetes. 67
Decreased estrogen is a crucial pathogenic factor for type 2 diabetes in postmenopausal women; however, the precise mechanism remains unknown. Orexin is a major hypothalamic neuropeptides regulating energy/glucose metabolism, and its anti-obese effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a98d9f00af6f81b97441d364ff05faf
https://doi.org/10.2337/db18-1851-p
https://doi.org/10.2337/db18-1851-p
Autor:
Kanta Kon, Hiroshi Tsuneki, Hisakatsu Ito, Yoshinori Takemura, Kiyofumi Sato, Mitsuaki Yamazaki, Yoko Ishii, Masakiyo Sasahara, Rudich, Assaf, Takahiro Maeda, Tsutomu Wada, Toshiyasu Sasaoka
Publikováno v:
Journal of Endocrinology; Oct2019, Vol. 243 Issue 1, p59-72, 14p