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pro vyhledávání: '"Kanoko Matsuura"'
Autor:
Kenta Kono, Rui Fujimura, Yuka Nakamura, Kanoko Matsuura, Ken-ichi Nunoya, Yoshiyuki Yamaura, Haruo Imawaka, Hiroshi Watanabe, Toru Maruyama
Publikováno v:
Molecular Pharmaceutics. 19:798-804
In human plasma, the main agent of hydrolysis of the ester-type prodrug of levodopa, designated ONO-2160, is alpha-1-acid glycoprotein (AGP), which is a mixture of the F1*S and A variants at molar ratios of 3:1 to 2:1. In this study, the mechanism of