Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kanoh Kondo"'
Autor:
Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Brain inflammation generally accelerates neurodegeneration but the mechanisms of this are not fully characterised. Here the authors show that PQBP1 in microglia is important for sensing extrinsic Tau 3 R/4 R proteins and triggers an innate immune res
Externí odkaz:
https://doaj.org/article/a6f77446056c4920834d3c51e49c5a27
Autor:
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E. Bianchi, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Tanaka et al use phosphoproteome analysis of post-mortem Alzheimer’s Disease (AD) brains and identified abnormal phosphorylation of Ku70, which leads to DNA damage and transcriptional repression-induced atypical cell death. In a mouse model of AD,
Externí odkaz:
https://doaj.org/article/fd80c0c5e83d4543afa38997ad8b886c
Autor:
Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Shingo Yamada, Xiaocen Jin, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Kazuhiko Tagawa, Naoki Atsuta, Masahisa Katsuno, Naoki Tomita, Katsutoshi Furukawa, Yuko Saito, Takashi Saito, Ayaka Ichise, Shinsuke Shibata, Hiroyuki Arai, Takaomi Saido, Marius Sudol, Shin-ichi Muramatsu, Hideyuki Okano, Elliott J. Mufson, Gen Sobue, Shigeo Murayama, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
The precise mechanisms of neuronal cell death in neurodegeneration are not fully understood. Here the authors show that YAP-mediated neuronal necrosis is increased in pre-symptomatic stages of Alzheimer’s disease and intervention to the necrosis re
Externí odkaz:
https://doaj.org/article/f3578dfd2ff148919a9dde2c540ddafd
Autor:
Satoshi Mizutani, Junko Nishio, Kanoh Kondo, Kaori Motomura, Zento Yamada, Shotaro Masuoka, Soichi Yamada, Sei Muraoka, Naoto Ishii, Yoshikazu Kuboi, Sho Sendo, Tetuo Mikami, Toshio Imai, Toshihiro Nanki
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 474 (2021)
CX3C Motif Chemokine Ligand 1 (CX3CL1; fractalkine) has been implicated in the pathogenesis of rheumatoid arthritis (RA) and its inhibition was found to attenuate arthritis in mice as well as in a clinical trial. Therefore, we investigated the effect
Externí odkaz:
https://doaj.org/article/c21147631aaf4f7da94e6a4dd6707d8b
Autor:
Hiroki Shiwaku, Shingo Katayama, Mengxuan Gao, Kanoh Kondo, Yuri Nakano, Yukiko Motokawa, Saori Toyoda, Fuyuko Yoshida, Hiroaki Hori, Tetsuo Kubota, Kinya Ishikawa, Hiroshi Kunugi, Yuji Ikegaya, Hitoshi Okazawa, Hidehiko Takahashi
Publikováno v:
Brain, Behavior, and Immunity. 111:32-45
Autor:
Su Liu, Kanoh Kondo, Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Hikari Tanaka, Nobutoshi Ito, Kazuhiko Tagawa, Yong Huang, Ryosuke Kawasaki, Sumire Takayama, Shin-ichi Tate, Hitoshi Okazawa, Teikichi Ikura
Publikováno v:
ACS Chemical Neuroscience. 12:3015-3027
Tau aggregation is a central hallmark of tauopathies such as frontotemporal lobar degeneration and progressive supranuclear palsy as well as of Alzheimer's disease, and it has been a target for therapeutic development. Herein, we unexpectedly found t
Autor:
Gaku Ohtomo, Kanoh Kondo, Katsutoshi Furukawa, Masaaki Waragai, Hidenori Homma, Shinsuke Shibata, Marius Sudol, Shingo Yamada, Hiroyuki Arai, Yuko Saito, Atsushi Iwata, Naoki Atsuta, Xiaocen Jin, Kazuhiko Tagawa, Hikari Tanaka, Ayaka Ichise, Takashi Saito, Masahisa Katsuno, Naoki Tomita, Hideyuki Okano, Kyota Fujita, Shin-ichi Muramatsu, Elliott J. Mufson, Gen Sobue, Hitoshi Okazawa, Shigeo Murayama, Takaomi C. Saido
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
Nature Communications
Nature Communications
The timing and characteristics of neuronal death in Alzheimer’s disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS),
Autor:
Hitomi Masuda, Teikichi Ikura, Kanoh Kondo, Meihua Jin, Yuki Yoshioka, Hitoshi Okazawa, Yu Yamamori, Shigeo Murayama, Kyota Fujita, Marco E. Bianchi, Sumire Takayama, Yukoh Nakazaki, Rie Tokuyama, Xiaocen Jin, Hidenori Homma, Hikari Tanaka, Kentaro Tomii, Nobutoshi Ito, Kazuhiko Tagawa, Takaomi C. Saido, Takashi Saito
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Communications Biology
Communications Biology
DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, whic
Autor:
Hiroki Shiwaku, Shingo Katayama, Kanoh Kondo, Yuri Nakano, Hikari Tanaka, Yuki Yoshioka, Kyota Fujita, Haruna Tamaki, Hironao Takebayashi, Omi Terasaki, Yukihiro Nagase, Teruyoshi Nagase, Tetsuo Kubota, Kinya Ishikawa, Hitoshi Okazawa, Hidehiko Takahashi
Publikováno v:
Cell reports. Medicine. 3(4)
From genetic and etiological studies, autoimmune mechanisms underlying schizophrenia are suspected; however, the details remain unclear. In this study, we describe autoantibodies against neural cell adhesion molecule (NCAM1) in patients with schizoph
Autor:
Kazuhiko Tagawa, Aurelian Kerever, Xigui Chen, Hikari Tanaka, Takashi Saito, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Shin-ichi Muramatsu, Shigeki Aoki, Hitoshi Okazawa, Takaomi C. Saido
Publikováno v:
Molecular Psychiatry
Early-phase pathologies of Alzheimer’s disease (AD) are attracting much attention after clinical trials of drugs designed to remove beta-amyloid (Aβ) aggregates failed to recover memory and cognitive function in symptomatic AD patients. Here, we s