Výsledky vyhledávání - "Kanneganti G.K. Murthy"

THE NOVEL INOSINE ANALOGUE INO-2002 EXERTS AN ANTI-INFLAMMATORY EFFECT IN A MURINE MODEL OF ACUTE LUNG INJURY

Autor: Pal Pacher, Kanneganti G.K. Murthy, Csaba Szabó, Garry J. Southan, Jon G. Mabley, Andrew L. Salzman, William Williams

Publikováno v: Shock. 32:258-262

Endogenous purines, including inosine, have been shown to exert immunomodulatory and anti-inflammatory effects in a variety of disease models. The dosage of inosine required for these effects has been shown to be between 200 and 600 mg kg(-1) because

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080269a8bea823d3c9b275d2d4d7fd22
https://doi.org/10.1097/shk.0b013e31819c3414

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Activation of Poly(ADP-Ribose) Polymerase by Myocardial Ischemia and Coronary Reperfusion in Human Circulating Leukocytes

Autor: Eszter Pankotai, Kanneganti G.K. Murthy, Zsuzsanna K. Zsengellér, Tamás Pék, Katarina Vargova, Domokos Gero, Róbert Gábor Kiss, Katalin Fekete, István Préda, Emese Toth-Zsamboki, Eszter M. Horváth, Zsombor Lacza, Csaba Szabó, Tamás Bárány

Publikováno v: Molecular Medicine. 12:221-228

Reactive free radical and oxidant production leads to DNA damage during myocardial ischemia/reperfusion. Consequent overactivation of poly(ADP-ribose) polymerase (PARP) promotes cellular energy deficit and necrosis. We hypothesized that PARP is activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56dcc5311229f3b27d7fd672b31e3df
https://doi.org/10.2119/2006-00055.toth-zsamboki

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Flagellin from Gram-Negative Bacteria is a Potent Mediator of Acute Pulmonary Inflammation in Sepsis

Autor: Kanneganti G.K. Murthy, Pal Pacher, Mikhail Y. Kirov, Andrew L. Salzman, László Virág, Lucas Liaudet, Lars J. Bjertnaes, Oleg V. Evgenov, Jon G. Mabley, Csaba Szabó, Anita Marton, Francisco Garcia Soriano

Publikováno v: Shock. 19:131-137

Flagellin is a recently identified bacterial product that elicits immune response via toll-like receptor 5. Here, we demonstrate that flagellin is an extraordinarily potent proinflammatory stimulus in the lung during sepsis. In vitro, flagellin trigg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8013af7b53b77b9aeeaf10e9da9b7289
https://doi.org/10.1097/00024382-200302000-00008

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Requirements of the RNA Polymerase II C-Terminal Domain for Reconstituting Pre-mRNA 3′ Cleavage

Autor: Kanneganti G.K. Murthy, Syuzo Kaneko, Kevin Ryan, James L. Manley

Publikováno v: Molecular and Cellular Biology. 22:1684-1692

RNA polymerase II (RNAP II) has previously been shown to be required for the pre-mRNA polyadenylation cleavage reaction in vitro. This activity was found to reside solely in the C-terminal domain (CTD) of the enzyme's largest subunit. Using a deletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e658182ca2bf82f5cb4d376a73b61410
https://doi.org/10.1128/mcb.22.6.1684-1692.2002

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Flagellin, a Novel Mediator of Salmonella-Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction

Autor: Andrew L. Salzman, László Virág, Francisco Garcia Soriano, Kanneganti G.K. Murthy, Lucas Liaudet, Gary F. Ross, Tonyia Eaves-Pyles, Csaba Szabó

Publikováno v: The Journal of Immunology. 166:1248-1260

Gram-negative sepsis is mediated by the actions of proinflammatory genes induced in response to microbes and their products. We report that flagellin, the monomeric subunit of flagella, is a potent proinflammatory species released by Salmonella. Flag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6649e1f078a0e9969d443adba0491d
https://doi.org/10.4049/jimmunol.166.2.1248

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High mobility group protein-1 (HMG-1) is a unique activator of p53

Autor: Lata Jayaraman, Kanneganti G.K. Murthy, Michael Bustin, Carol Prives, Narayani Chandra Moorthy, James L. Manley

Publikováno v: Genes & Development. 12:462-472

The binding of p53 protein to DNA is stimulated by its interaction with covalent as well as noncovalent modifiers. We report the identification of a factor from HeLa nuclear extracts that activates p53 DNA binding. This factor was purified to homogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b19086445cd26da07d177ca22fa3529
https://doi.org/10.1101/gad.12.4.462

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Autor: Kanneganti G.K. Murthy, Carol Prives, James L. Manley, Diana Foukal Colgan

Publikováno v: Nature. 384:282-285

THE poly(A) tail found on almost all eukaryotic messenger RNAs1,2 is important in enhancing translation initiation and determining mRNA stability3,4. Control of poly (A)-tail synthesis thus has the potential to be a key regulatory step in gene expres

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https://doi.org/10.1038/384282a0

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Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus

Autor: Kanneganti G.K. Murthy, James L. Manley

Publikováno v: Journal of Biological Chemistry. 267:14804-14811

Cleavage-polyadenylation specificity factor (CPSF) is one of five separable factors known to be required for 3' cleavage and polyadenylation of mRNA precursors in vitro. Previous studies have shown that the cleavage and poly(A) addition reactions can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::144bbad6f18cd899d7fc8cae4e16bfea
https://doi.org/10.1016/s0021-9258(18)42111-4

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The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes

Autor: William Williams, Kanneganti G.K. Murthy, Pal Pacher, Garry J. Southan, Jon G. Mabley, Andrew L. Salzman, Csaba Szabó

Publikováno v: The Journal of endocrinology. 198(3)

Endogenous purines including inosine have been shown to exert immunomodulatory and anti-inflammatory effects in a variety of disease models. The dosage of inosine required for protection is very high because of the rapid metabolism of inosine in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a349354401b850b3b0c5f429023f3
https://pubmed.ncbi.nlm.nih.gov/18562629

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Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation

Autor: Kanneganti G.K. Murthy, Csaba Szabó, Márk Kollai, Jon G. Mabley, Anne Vaslin, Eszter M. Horváth, Rita Benko, Zsuzsanna K. Zsengellér

Publikováno v: University of Brighton

Activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of various cardiovascular and inflammatory diseases. Here, we report that the gender-specific inflammatory response is preferentially down-regulated by PARP i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7b2d5db3995c4af14bedab9940f621
https://pubmed.ncbi.nlm.nih.gov/16079296

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