Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kannan Thirunavukkarasu"'
Publikováno v:
BioTechniques, Vol 28, Iss 3, Pp 506-510 (2000)
Luciferase reporter vectors are commonly used for the functional analysis of basal promoter and enhancer elements of eukaryotic genes. Randomly occurring cisacting elements in the vector sequences that can spuriously respond to various transcription
Externí odkaz:
https://doaj.org/article/acc69be2483a415b8bc7b914ff488361
Autor:
Divyani Paul, Madelyn H Miller, Josh Born, Shayak Samaddar, Huanzhen Ni, Hugo Avila, Venkata R. Krishnamurthy, Kannan Thirunavukkarasu
Publikováno v:
Expert Opinion on Drug Discovery. 18:193-206
Fibrotic lung diseases represent a large subset of diseases with an unmet clinical need. Oligonucleotide therapies (ONT) are a promising therapeutic approach for the treatment of pulmonary disease as they can inhibit pathways that are otherwise diffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c8a1ea69237d638a6c12eb3151593f
https://doi.org/10.1080/17460441.2023.2160439
https://doi.org/10.1080/17460441.2023.2160439
Autor:
Josef G, Heuer, Catalina M, Meyer, Hana E, Baker, Andrea, Geiser, Jonathan, Lucchesi, Daniel, Xu, Matthew, Hamang, Jennifer A, Martin, Charlie, Hu, Kenneth D, Roth, Kannan, Thirunavukkarasu, Jorge, Alsina-Fernandez, Yanfei L, Ma
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:287-298
Urocortin-1 (UCN1) is a member of the corticotropin releasing hormone (CRH) family of peptides that acts through CRH-receptor 1 (CRHR1) and CRH-receptor 2 (CRHR2). UCN1 can induce the adrenocorticotropin hormone and downstream glucocorticoids through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e901ccde71fc1559ceeb78b57a66ba8
https://doi.org/10.1124/jpet.122.001151
https://doi.org/10.1124/jpet.122.001151
Autor:
Kannan Thirunavukkarasu, Mark Chambers, Daniel R. Mudra, Michael Robert Wiley, Craig A. Swearingen, Lisa A. Adams, Timothy B. Durham, Jothirajah Marimuthu, C. Lin, James Lee Toth, Chin Liu
Publikováno v:
Journal of Medicinal Chemistry. 60:5933-5939
Aggrecanase-1 and -2 (ADAMTS-4 and ADAMTS-5) are zinc metalloproteases involved in the degradation of aggrecan in cartilage. Inhibitors could provide a means of altering the progression of osteoarthritis. We report the identification of 7 which had g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1aa6bde3d0801758aea530059c1a40
https://doi.org/10.1021/acs.jmedchem.7b00650
https://doi.org/10.1021/acs.jmedchem.7b00650
Autor:
Guilherme Rocha, Bailin Tan, Denis J. McCann, Lance Allen Pfeifer, Craig A. Swearingen, Spencer B. Jones, Kannan Thirunavukkarasu, Hai H Bui, Bryan H. Norman, Joy K. Saha
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 359:207-214
Autotaxin is a secreted enzyme that catalyzes the conversion of lysophosphatidyl choline into the bioactive lipid mediator lysophosphatidic acid (LPA). It is the primary enzyme responsible for LPA production in plasma. It is upregulated in inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d250eb5fc1795659092707a352ba0089
https://doi.org/10.1124/jpet.116.234013
https://doi.org/10.1124/jpet.116.234013
Autor:
Thomas James Beauchamp, Thomas J. Bleisch, Norman Earle Hughes, Daniel R. Mudra, Srinivasan Chandrasekhar, Bryan H. Norman, Hai Bui, Jim D. Durbin, Spencer B. Jones, Yen Dao, Kannan Thirunavukkarasu, Mark Chambers, Denis J. McCann, J.L. Oskins, Joseph Michael Gruber, Lance Allen Pfeifer, Craig A. Swearingen, Christopher John Rito, V. Joseph Klimkowski, C. Lin
Publikováno v:
ACS Medicinal Chemistry Letters. 7:857-861
In an effort to develop a novel therapeutic agent aimed at addressing the unmet need of patients with osteoarthritis pain, we set out to develop an inhibitor for autotaxin with excellent potency and physical properties to allow for the clinical inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095ce4b285974ea117e2612b0b46c193
https://doi.org/10.1021/acsmedchemlett.6b00207
https://doi.org/10.1021/acsmedchemlett.6b00207
Autor:
Kannan Thirunavukkarasu, Mark Chambers, Daniel R. Mudra, Craig A. Swearingen, Lisa A. Adams, Jennifer M. Weller, P.G. Mitchell, Timothy B. Durham, Chin Liu, C. Lin, James Lee Toth, Michael Robert Wiley, Jothirajah Marimuthu
Publikováno v:
Journal of Medicinal Chemistry. 59:5810-5822
The development of reliable relationships between in vivo target engagement, pharmacodynamic activity, and efficacy in chronic disease models is beneficial for enabling hypothesis-driven drug discovery and facilitating the development of patient-focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f252c22eeb38a66a724a46f915a1a225
https://doi.org/10.1021/acs.jmedchem.6b00398
https://doi.org/10.1021/acs.jmedchem.6b00398
Autor:
Deveree Partridge, Craig A. Swearingen, Molly McFadden, Justin M. Haller, Kannan Thirunavukkarasu, Thomas F. Higgins
Publikováno v:
Clinical Orthopaedics and Related Research®. 473:3280-3288
Posttraumatic osteoarthritis (OA) is a variant of OA that can develop after articular injury. Although the mechanism(s) of posttraumatic OA are uncertain, the presence and impact of postinjury proteolytic enzymes on articular cartilage remain unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2369c7979643d2e51067ec6f4e0dc3c7
https://doi.org/10.1007/s11999-015-4441-4
https://doi.org/10.1007/s11999-015-4441-4
Autor:
C. Lin, Chin Liu, Valentine J. Klimkowski, Craig A. Swearingen, Lisa A. Adams, Stephanie L. Stout, Timothy B. Durham, Michael Robert Wiley, Kannan Thirunavukkarasu, Mark Chambers, Jim D. Durbin, Christopher John Rito, Jothirajah Marimuthu, James Lee Toth
Publikováno v:
Journal of Medicinal Chemistry. 57:10476-10485
A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are zinc metalloproteases commonly referred to as aggrecanase-1 and aggrecanase-2, respectively. These enzymes are involved in the degradation of aggrecan, a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f736425e180822aa9917bf1821dbef6
https://doi.org/10.1021/jm501522n
https://doi.org/10.1021/jm501522n
Autor:
Bryan H. Norman, Spencer B. Jones, Kannan Thirunavukkarasu, Mark Chambers, Craig A. Swearingen, P.G. Mitchell, Lance Allen Pfeifer, J.L. Oskins, H.H. Bui, C. Lin
Publikováno v:
Osteoarthritis and cartilage. 25(6)
Summary Objective Autotaxin is a secreted lysophospholipase that mediates the conversion of lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA), a bioactive lipid mediator. Autotaxin levels in plasma and synovial fluid correlate with diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674054280c92bb3b1ec61ef980d93c84
https://pubmed.ncbi.nlm.nih.gov/27638130
https://pubmed.ncbi.nlm.nih.gov/27638130