Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kannan P Naicker"'
Autor:
Ying Zhai, Ellen Xia, Lei Chen, Bandarpalle B. Shankar, Qingbei Zeng, Anilkumar G. Nair, Sony Agrawal, Ronald N. Buckle, Guowei Zhou, Kannan P. Naicker, John P. Caldwell, Ling Tong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Kerry Keertikar, Haiqun Tang, Seong Heon Kim, Rong Liu, De-Yi Yang, Paul Ingravallo, Gregory Scott Martin, Samuel A. Vellekoop, Melissa L. Allard, Christian L. Holst, Michael P. Dwyer, Amin A. Nomeir, Robert Mazzola, Polivina Jolicia F Gauuan, Joseph A. Kozlowski, Oleg Selyutin, Rong Kong
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(5)
HCV NS5A inhibitors have shown impressive in vitro potency profiles in HCV replicon assays thus making them attractive components for inclusion in an all oral fixed dose combination treatment regimen. Herein we describe the research efforts that led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85586f1ce259c9e4c3146d6078489ecd
https://pubmed.ncbi.nlm.nih.gov/26850003
https://pubmed.ncbi.nlm.nih.gov/26850003
Autor:
Kannan P Naicker, Shibo Jiang, Louise Boyer-Chatenet, Asim K. Debnath, Jiahong Ni, Hong Lu, Lai-Xi Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1215-1220
A structure-based design approach has been used to optimize a lead HIV-1 entry inhibitor targeted to the envelope glycoprotein gp41. The docking study on this lead compound revealed important structural requirements that need to be preserved as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95eb969824f6652b514cd98ea2761232
https://doi.org/10.1016/j.bmc.2003.11.006
https://doi.org/10.1016/j.bmc.2003.11.006
Autor:
Rajender S. Varma, Kannan P. Naicker
Publikováno v:
Tetrahedron Letters. 40:6177-6180
An efficient solid state synthesis of amides is described from non-enolizable esters and amines using potassium tert-butoxide under microwave irradiation conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da17961bdf6ad53e344168eb2fe61c7d
https://doi.org/10.1016/s0040-4039(99)01209-5
https://doi.org/10.1016/s0040-4039(99)01209-5
Publikováno v:
Synthetic Communications. 29:2823-2830
A high yield synthesis of alkyl azides is described from readily accessible alkyl bromides and sodium azide using a recyclable phase transfer catalyst, 18-crown-6 ether impregnated clay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4391de27fe410854a1ff153eb2f578f2
https://doi.org/10.1080/00397919908086450
https://doi.org/10.1080/00397919908086450
Publikováno v:
Organic Letters. 1:189-192
An efficient solid-state oxidation of organic molecules is described using a stable, inexpensive, and easily handled reagent, the urea−hydrogen peroxide adduct. The generality of the reaction has been demonstrated in oxidation of several molecules,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1355f41547ceec6c728e8a56d17f9e
https://doi.org/10.1021/ol990522n
https://doi.org/10.1021/ol990522n
Publikováno v:
Tetrahedron Letters. 40:2075-2078
A new modified clay material, prepared by intercalating palladium chloride and tetraphenylphosphonium bromide into montmorillonite K10 clay, catalyzes the Heck reaction and affords trans -stilbenes in high yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7795769738167308fd2d32973bd26f4
https://doi.org/10.1016/s0040-4039(99)00149-5
https://doi.org/10.1016/s0040-4039(99)00149-5
Autor:
Kannan P. Naicker, Rajender S. Varma
Publikováno v:
Tetrahedron Letters. 40:439-442
A facile method for the preparation of biaryl compounds is described from readily accessible aryl halides and arylboronic acids using palladium chloride/tetraphenylphosphonium bromide intercalated clay as a new catalyst.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b934f032a476767464d7dca84eef047b
https://doi.org/10.1016/s0040-4039(98)02403-4
https://doi.org/10.1016/s0040-4039(98)02403-4
Publikováno v:
Tetrahedron Letters. 39:8437-8440
A solventless and expeditious method for the preparation of alcohols is described from aldehydes using barium hydroxide, Ba(OH)2.8H2O, and paraformaldehyde. A comparison of this microwave-accelerated Cannizzaro reaction to the one under conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d3edc094c7643382ba59a4ed4069801
https://doi.org/10.1016/s0040-4039(98)01922-4
https://doi.org/10.1016/s0040-4039(98)01922-4
Autor:
Rajender S. Varma, Kannan P. Naicker
Publikováno v:
Tetrahedron Letters. 39:7463-7466
A simple and expeditious method for the preparation of 1,2-cis diols is described from olefins using an inexpensive oxidant potassium permanganate, KMnO4, via sonochemical activation in aqueous media.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fc7e19fbb9cfabc64b2451473617733
https://doi.org/10.1016/s0040-4039(98)01671-2
https://doi.org/10.1016/s0040-4039(98)01671-2
Selective nitration of styrenes with clayfen and clayan: A solvent-free synthesis of β-nitrostyrenes
Publikováno v:
Tetrahedron Letters. 39:3977-3980
A facile solvent-free synthesis of β-nitrostyrenes is described from styrene and its substituted derivatives using inexpensive ‘doped’ clay reagents, clayfen and clayan.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::882f79358b4cf567ce601094089b8e9b
https://doi.org/10.1016/s0040-4039(98)00740-0
https://doi.org/10.1016/s0040-4039(98)00740-0