Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

Autor: Sidharta PN, Melchior M, Kankam MK, Dingemanse J

Publikováno v: Drug Design, Development and Therapy, Vol Volume 13, Pp 949-964 (2019)

Patricia N Sidharta,1 Meggane Melchior,1 Martin K Kankam,2 Jasper Dingemanse1 1Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil CH-4123, Switzerland; 2Vince and Associates Clinical Research, Overland Park, KS 66211, USA Bac

Externí odkaz: https://doaj.org/article/e43242bd80c04af9a0ce15ee90d8ca90

A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of V-7404 in Healthy Adult Volunteers.

Autor: Kankam MK; Altasciences, Overland Park, Kansas, USA., Burns JM; ViroDefense, Chevy Chase, Maryland, USA., Collett MS; ViroDefense, Chevy Chase, Maryland, USA., Corrado ML; Independent Consultant/Advisor, Perkasie, Pennsylvania, USA., Hincks JR; ViroDefense, Chevy Chase, Maryland, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Sep 17; Vol. 65 (10), pp. e0102921. Date of Electronic Publication: 2021 Aug 09.

Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults.

Autor: Griffin MP; MedImmune (AstraZeneca), Gaithersburg, Maryland, USA griffinp@medimmune.com., Khan AA; MedImmune (AstraZeneca), Gaithersburg, Maryland, USA., Esser MT; MedImmune (AstraZeneca), Gaithersburg, Maryland, USA., Jensen K; MedImmune (AstraZeneca), Gaithersburg, Maryland, USA., Takas T; MedImmune (AstraZeneca), Gaithersburg, Maryland, USA., Kankam MK; Vince and Associates Clinical Research, Overland Park, Kansas, USA., Villafana T; MedImmune (AstraZeneca), Gaithersburg, Maryland, USA., Dubovsky F; MedImmune (AstraZeneca), Gaithersburg, Maryland, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Feb 23; Vol. 61 (3). Date of Electronic Publication: 2017 Feb 23 (Print Publication: 2017).

Safety, tolerability, and immunogenicity of a 4-antigen Staphylococcus aureus vaccine (SA4Ag): Results from a first-in-human randomised, placebo-controlled phase 1/2 study.

Autor: Frenck RW Jr; Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, United States. Electronic address: robert.frenck@cchmc.org., Creech CB; Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine, S-2323 MCN, 1161 21st Avenue South, Nashville, TN 37232, United States., Sheldon EA; Miami Research Associates, 6141 Sunset Dr., South Miami, FL 33143, United States., Seiden DJ; Broward Research Group, 7261 Sheridan Street, Suite 210, Hollywood, FL 33024, United States., Kankam MK; Vince and Associates Clinical Research, 10103 Metcalf Ave, Overland Park, KS 66212, United States., Baber J; Pfizer Australia Pty Ltd, Sydney, 38-42 Wharf Rd, West Ryde, NSW 2114, Australia., Zito E; Pfizer Vaccine Research and Development, Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, United States., Hubler R; Pfizer Vaccine Research and Development, Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, United States., Eiden J; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States., Severs JM; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States., Sebastian S; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States., Nanra J; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States., Jansen KU; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States., Gruber WC; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States., Anderson AS; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States., Girgenti D; Pfizer Vaccine Research and Development, Pfizer Inc, 401 N Middletown Road, Pearl River, NY 10965, United States.

Publikováno v: Vaccine [Vaccine] 2017 Jan 05; Vol. 35 (2), pp. 375-384. Date of Electronic Publication: 2016 Dec 01.

Knowledge in relation to cadaveric kidney donation in urban blacks.

Autor: Kankam MK; Epidemiology Branch, U.S. Food and Drug Administration, Rockville, MD 20857., Ktsanes VK, Moore RM Jr, Kaczmarek RG, Jeng LL

Publikováno v: Journal of health care for the poor and underserved [J Health Care Poor Underserved] 1990 Winter; Vol. 1 (3), pp. 297-304.