Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Kanji Meguro"'
Autor:
Hironao Sajiki, Yasunari Monguchi, Tomohiro Ichikawa, Hayato Masuda, Yoshinari Sawama, Kanji Meguro, Riichi Miyamoto, Tomohiro Matsuo, Hongzhi Bai, Aya Ogawa, Yutaka Kobayashi, Tsuyoshi Yamada
Publikováno v:
Organic Process Research & Development. 23:462-469
A practical and efficient method for scavenging palladium leached into the reaction mixture using thiol-modified dual-pore silica beads has been developed. Reducing the level of metal contamination, especially palladium, in pharmaceutical and bioacti
Autor:
Tetsuo Nakabayashi, Akihisa Maeda, Takashi Dan, Kenji Murano, Nagahisa Yamaoka, Toshio Miyata, Hidehiko Kodama, Kanji Meguro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:809-813
Novel plasminogen activator inhibitor-1 (PAI-1) inhibitors with highly improved oral bioavailability were discovered by structure-activity relationship studies on N-acyl-5-chloroanthranilic acid derivatives. Because lipophilic N-acyl groups seemed to
Publikováno v:
Bulletin of the Chemical Society of Japan. 90:178-187
Treatment of 4,6-di(substituted)amino-1,2-dihydro-1,3,5-triazine derivative (5) with sodium chloride in a bilayer system consisting of toluene and water gave its hydrochloride (6) in the toluene layer and sodium hydroxide in the aqueous layer. Simila
Autor:
Kanji Meguro, Yasuhiko Kawano, Masafumi Katsuda, Shuji Akai, Kazuki Takada, Hirofumi Tsujino, Takeshi Saiki, Tadayuki Uno, Akira Takagi, Taku Yamashita, Shotaro Maeda, Shigeaki Masuda
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(19)
Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that acts on the first and rate-limiting step of the tryptophan/kynurenine pathway. Since the pathway is one of the means of cancer immune evasion, IDO1 inhibitors have drawn interest a
Autor:
Hiroki Abe, Sergey Stvolinsky, Sato Tatsunori, Kanji Meguro, Alexander A. Boldyrev, Maxim Antipin
Publikováno v:
Rejuvenation Research. 13:453-457
This study investigated the effect of antioxidants, i.e., carnosine and its Trolox- (water-soluble analog of alpha-tocopherol) acylated derivatives (S,S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carbonyl-beta-alanyl-L-histidine (S,S-Trolox-carnosine, S
Publikováno v:
Journal of Medicinal Chemistry. 52:597-600
A series of novel 4,6-di(substituted)amino-1,2-dihydro-1,3,5-triazine derivatives designed to have ClogP of 5.1-7.5 was synthesized and evaluated for their antiseptic properties by MIC and MBC tests against Gram-positive and Gram-negative bacteria, i
Autor:
Toshio Miyawaki, Shun-Ichi Murahashi, Dazhi Zhang, Masaaki Uenaka, Kenji Murano, Hiroki Iida, Kanji Meguro
Publikováno v:
ChemInform. 46
An efficient and practical catalytic method for the aerobic oxidative transformation of sulfides into sulfoxides, and thiols into disulfides with formic acid/TEA in the presence of a new, readily available, and stable flavin catalyst 5d is described.
Publikováno v:
YAKUGAKU ZASSHI. 122:909-918
Insulin resistance is a characteristic feature of type II diabetes as well as obesity. This insulin resistant state at the peripheral tissue level causes impaired glucose utilization, leading to hyperglycemia. Studies of antidiabetic agents by Takeda
Autor:
Toshio Miyawaki, Dazhi Zhang, Kanji Meguro, Shun-Ichi Murahashi, Kenji Murano, Masaaki Uenaka, Hiroki Iida
Publikováno v:
Chemical communications (Cambridge, England). 50(71)
An efficient and practical catalytic method for the aerobic oxidative transformation of sulfides into sulfoxides, and thiols into disulfides with formic acid/TEA in the presence of a new, readily available, and stable flavin catalyst 5d is described.
Autor:
Hiroyuki Tawada, Noriaki Kawamura, Hitoshi Ikeda, Masahiro Kajino, Eiichiro Ishikawa, Kanji Meguro, Yasuo Sugiyama, Myles Harcourt
Publikováno v:
Journal of Medicinal Chemistry. 37:2079-2084
A series of 3-quinolylurea derivatives (1) was synthesized and evaluated for acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory activity. For in vitro studies, the most potent inhibitory activity was found in derivatives having substituents at th