Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kanika Varshney"'
Autor:
Kanika Varshney, Arvind K. Srivastava, Sudha Jain, Akansha Mishra, Amit K Gupta, Mridula Saxena, Rohit Srivastava, Anil Kumar Saxena, Arun Rawat
Publikováno v:
Chemical Biology & Drug Design. 94:1378-1389
In our continued effort to discover novel PTP1B inhibitor with improved in vivo activity, we attempted to optimize our previously discovered lead compound by replacing the sulfonyl group with benzoyl group to yield compound II. Additional structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e0b4d81a6bf3fe63cf9d93ae0645bc
https://doi.org/10.1111/cbdd.13515
https://doi.org/10.1111/cbdd.13515
Autor:
Amit K. Gupta, Salil Varshney, Kanika Varshney, Ravi Sonkar, Sudha Jain, Arvind K. Srivastava, Anil Kumar Saxena, Akanksha Mishra, Mridula Saxena, Anil N. Gaikwad, Geetika Bhatia
A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Of the 12 tested, 3 compounds (6c, 7b and 7d) showed good anti-oxidant activity, compound 6c attenuated LDL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b185bff533b25739b33a1767f0b401e
Autor:
Vaibhav Mishra, Anil K. Saxena, Gautam Palit, Amit K. Gupta, Neetu Singh, Mridula Saxena, Kanika Varshney
Publikováno v:
Journal of Chemical Information and Modeling. 53:176-187
The present study revisited the three-dimensional (3D) homology model of CCK-2R using human A(2a) adenosine receptor and the resolved NMR based structure of the third extracellular loop of the CCK-2R as templates. Further in order to identify novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b25b0dfaafd425eff01c9ee66e12a12
https://doi.org/10.1021/ci3003655
https://doi.org/10.1021/ci3003655
Autor:
Amit K, Gupta, Kanika, Varshney, Vivek, Kumar, Kumkum, Srivastava, Aditya B, Pant, Sunil K, Puri, Anil K, Saxena
Publikováno v:
Archiv der Pharmazie. 350(3-4)
A series of substituted 1,2,4-trioxanes were synthesized and evaluated for their antimalarial potential, in silico ADME properties and cytotoxicity on neuronal cell lines. Among the 15 synthesized substituted 1,2,4-trioxanes, two compounds (compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f20e684df35ad469cd1dc8b9231b51d
https://pubmed.ncbi.nlm.nih.gov/28207169
https://pubmed.ncbi.nlm.nih.gov/28207169
Autor:
Swati Gupta, Kanika Varshney, Anil K. Saxena, Akhilesh K. Tamarkar, Nagendra Singh, Arun Kumar Rawat, Arvind K. Srivastava, Neha Rahuja
Publikováno v:
ChemMedChem. 7:1185-1190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c2515d593983252d872acb84473616
https://doi.org/10.1002/cmdc.201200197
https://doi.org/10.1002/cmdc.201200197
Autor:
Kanika Varshney, Anil K. Saxena, Amit K. Gupta, Sunil K. Puri, Vivek Kumar, Kumkum Srivastava, Aditya B. Pant
Publikováno v:
Archiv der Pharmazie. 350:1600335
A series of substituted 1,2,4-trioxanes were synthesized and evaluated for their antimalarial potential, in silico ADME properties and cytotoxicity on neuronal cell lines. Among the 15 synthesized substituted 1,2,4-trioxanes, two compounds (compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::150f30b233bc4907b1c1d7e0d4f9cbaf
https://doi.org/10.1002/ardp.201600335
https://doi.org/10.1002/ardp.201600335
Toward the identification of a reliable 3D QSAR pharmacophore model for the CCK2 receptor antagonism
Publikováno v:
Journal of chemical information and modeling. 52(5)
The present study describes application of computational approaches to identify a validated and reliable 3D QSAR pharmacophore model for the CCK-2R antagonism through integrated ligand and structure based studies using anthranilic sulfonamide and 1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699d8a1380e61f7d695bef2bee9d024f
https://pubmed.ncbi.nlm.nih.gov/22530718
https://pubmed.ncbi.nlm.nih.gov/22530718
Publikováno v:
SAR and QSAR in environmental research. 21(5-6)
Hsp90 (Heat shock protein 90) is an important therapeutic target for the treatment of cancer. To identify important chemical features for Hsp90 inhibitory activity, a 3D-QSAR pharmacophore model was developed using a set of 61 inhibitors (a training
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5c80d5ceef989c65095169b717b481
https://pubmed.ncbi.nlm.nih.gov/20818581
https://pubmed.ncbi.nlm.nih.gov/20818581
Autor:
Arun Rawat, Rohit Srivastava, Arvind K. Srivastava, Swati Gupta, Kanika Varshney, Anil K. Saxena, Neha Rahuja
Publikováno v:
MedChemComm. 4:1382
The protein tyrosine phosphatase 1B (PTP1B) is an attractive target for the treatment of type 2 diabetes. A series of substituted 1,3-benzyl urea has been synthesized and evaluated for PTP1B inhibitory, antidiabetic and antidyslipidemic activities. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e3dbd996936dc4bb236daad47685e0
https://doi.org/10.1039/c3md00138e
https://doi.org/10.1039/c3md00138e