Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kangjian Qiao"'
Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica
Autor:
Yongshuo Ma, Nian Liu, Per Greisen, Jingbo Li, Kangjian Qiao, Sanwen Huang, Gregory Stephanopoulos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Substrate inhibition has not been widely studied in the context of synthetic biology and metabolic engineering. Here, the authors report removal of lycopene substrate inhibition by two different strategies and enable high carotenoid productivity in Y
Externí odkaz:
https://doaj.org/article/dd3a3ea70ed74d4caad90f94a57dc8f8
Autor:
Sivan Elloul, Anne-Sophie Dugast, Shannon McArdel, Enping Hong, Arjun Bollampalli, Maegan Hoover, Sneha Pawar, Viral Amin, Kangjian Qiao, Christopher Ta, Laurence Turka, Thomas Wickham
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/8a6fd99397684961baede2a785881b1e
Publikováno v:
F1000Research, Vol 5 (2016)
In this perspective, we highlight recent examples and trends in metabolic engineering and synthetic biology that demonstrate the synthetic potential of enzyme and pathway engineering for natural product discovery. In doing so, we introduce natural pa
Externí odkaz:
https://doaj.org/article/77dcb96595694d9592496897b5617e5c
Autor:
S. Haihua Chu, Elizabeth Budak, Nandini Mondal, Kathy Zhang, Alexander Harmon, Jeffrey Wong, Dieter Lam, Corrina Lucini, Brent Coisman, Kangjian Qiao, Tao Bai, Jeremy Decker, Bob Gantzer, Kindo Lee, Maya Sen, Tanggis Bohnuud, Luis Barrera, Brian Cafferty, Seung-Joo Lee, Paul Kopesky, Nicole M. Gaudelli, Charlotte F McDonagh, Giuseppe Ciaramella, Adam J. Hartigan
Publikováno v:
Blood. 140:10213-10214
Autor:
Nandini Mondal, Alexander Harmon, Elizabeth Budak, Kathy Zhang, Jeffrey Wong, Conrad Rinaldi, Jenny Olins, Kara Hoar, Archita Venugopal Menon, Moriah White, Faith Musenge, Adam Camblin, Adam Wolin, Brent Coisman, Tao Bai, Kangjian Qiao, Mudra Patel, Jeremy Decker, Bob Gantzer, Thomas Leete, Yi Yu, Tanggis Bohnuud, Seung-Joo Lee, Sarah Smith, Charlotte F McDonagh, Nicole M. Gaudelli, S. Haihua Chu, Adam J. Hartigan, Giuseppe Ciaramella
Publikováno v:
Blood. 140:4487-4488
Autor:
Adrian Fay, Eduard J. Kerkhoven, Yun Lee, Ziyu Dai, Matthew K. Theisen, Thomas M. Wasylenko, Kyle R. Pomraning, James C. Liao, Peng Xu, Erin L. Bredeweg, Andrew M. Silverman, Kangjian Qiao, Po Wei Chen, Nian Liu, Sagar Chakraborty, Jimmy G. Lafontaine Rivera, Michael Gossing, Jens Nielsen, Andreas E. Vasdekis, Hongjuan Liu, Sue A. Karagiosis, Gregory Stephanopoulos, Scott E. Baker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ae5398035091cc60a67959f1ee265a
https://doi.org/10.2172/1821178
https://doi.org/10.2172/1821178
Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica
Autor:
Yongshuo Ma, Nian Liu, Per Greisen, Jingbo Li, Kangjian Qiao, Sanwen Huang, Gregory Stephanopoulos
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Substrate inhibition of enzymes can be a major obstacle to the production of valuable chemicals in engineered microorganisms. Here, we show substrate inhibition of lycopene cyclase as the main limitation in carotenoid biosynthesis in Yarrowia lipolyt
Autor:
Anne-Sophie Dugast, Maegan Hoover, Sivan Elloul, Christopher Ta, Shannon McArdel, Kangjian Qiao, Arjun Bollampalli, Sneha Pawar, Enping Hong, Laurence A. Turka, Thomas Wickham, Viral Amin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Agonist antibodies and recombinant cytokines have had limited success in the clinic due to three factors: severe toxicity leading to a narrow therapeutic index, the diminished activity of an agonistic antibody compared with natural ligand,
Publikováno v:
Metabolic Engineering. 44:38-44
Escherichia coli was metabolically engineered to effectively produce a series of biopolymers consisted of four types of monomers including glycolate, lactate, 3-hydroxybutyrate and 4-hydroxybutyrate from glucose as the carbon source. The biosynthetic
Publikováno v:
Biotechnology and Bioengineering. 114:1521-1530
Microbially derived lipids have recently attracted renewed interests due to their broad applications in production of green diesels, cosmetic additives, and oleochemicals. Metabolic engineering efforts have targeted a large portfolio of biosynthetic