Zobrazeno 1 - 10
of 372
pro vyhledávání: '"Kangdong Liu"'
Autor:
Jing Zhang, Qiong Wu, Yifei Xie, Feng Li, Huifang Wei, Yanan Jiang, Yan Qiao, Yinhua Li, Yanan Sun, Han Huang, Mengmeng Ge, Dengyun Zhao, Zigang Dong, Kangdong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4329-4344 (2024)
Esophageal squamous cell carcinoma (ESCC), a malignancy of the digestive system, is highly prevalent and the primary cause of cancer-related deaths worldwide due to the lack of early diagnostic biomarkers and effective therapeutic targets. Dysregulat
Externí odkaz:
https://doaj.org/article/8c8ea80c7d9b426b85c6cc45a10bd72d
Autor:
Fangfang Liu, Jingyu Chen, Kai Li, Haochen Li, Yiyi Zhu, Yubo Zhai, Bingbing Lu, Yanle Fan, Ziyue Liu, Xiaojie Chen, Xuechao Jia, Zigang Dong, Kangdong Liu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-50 (2024)
Abstract Ubiquitination, a pivotal posttranslational modification of proteins, plays a fundamental role in regulating protein stability. The dysregulation of ubiquitinating and deubiquitinating enzymes is a common feature in various cancers, undersco
Externí odkaz:
https://doaj.org/article/60bb33dd28884da89151376617db8aa5
Autor:
Jian Li, Xinli Ma, Xiaoyu Wang, Xiaotong Hu, Shaobo Fang, Guoguo Jin, Kangdong Liu, Zigang Dong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Serine/threonine protein kinase 19 (STK19) has been reported to phosphorylate and activate oncogenic NRAS to promote melanomagenesis. However, concerns have been raised about whether STK19 is a kinase. STK19 has also been identified as a put
Externí odkaz:
https://doaj.org/article/8b59635546f140cabbbaec6e7cd84208
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Erianin is one of the most representative bibenzyls with significant inhibitory activity against a wide range of tumor cells. However, the low erianin level in natural materials has severely inhibited its further development in health care. Our aim w
Externí odkaz:
https://doaj.org/article/b3ab6c6db6e14f27abb857a1acdefa80
Autor:
Qiang Yuan, Yunshu Shi, Yuhan Zhang, Yaqian Shi, Zubair Hussain, Jimin Zhao, Yanan jiang, Yan Qiao, Yaping Guo, Jing Lu, Ziming Dong, Zigang Dong, Junyong Wang, Kangdong Liu
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of digestive system tumor related death in the world. Unfortunately, effective chemopreventive agent is lack for patients with ESCC in clinical practice, which
Externí odkaz:
https://doaj.org/article/2101e771dc4745c587afba4ea676817d
Autor:
Xuebo Lu, Weizhe Zhang, Xiaoxiao Yang, Xiao Yan, Zubair Hussain, Qiong Wu, Jinmin Zhao, Baoyin Yuan, Ke Yao, Zigang Dong, Kangdong Liu, Yanan Jiang
Publikováno v:
Translational Oncology, Vol 50, Iss , Pp 102136- (2024)
Background: Gastric cancer (GC) is a significant global concern, ranking as the fifth most prevalent cancer. Unfortunately, the five-year survival rate is less than 30 %. Additionally, approximately 50 % of patients experience a recurrence or metasta
Externí odkaz:
https://doaj.org/article/b627deeaada440829affae5203e62120
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Protein translation is a tightly regulated cellular process that is essential for gene expression and protein synthesis. The deregulation of this process is increasingly recognized as a critical factor in the pathogenesis of various human di
Externí odkaz:
https://doaj.org/article/688ce14ee90e4e4a90acba7df4d5f0d3
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-29 (2024)
Abstract Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved in almost all cancer hallmark features including tumor proliferation, metastasis, angiogenesis, immunosuppression, tumor inflammation, metabolism
Externí odkaz:
https://doaj.org/article/c0db242f0e6e4c5288c248f5f2f12592
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-34 (2023)
Abstract The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly dysregulated in human malignancies by processes driven by RAS or RAF oncogenes. Among the members of the RAF kinase family, CRAF plays an important role in the RAS
Externí odkaz:
https://doaj.org/article/d125e847832a4435a5db541aafe5edfc
Autor:
Tingxuan Gu, Mengqiao Wang, Xiaorong Fu, Xueli Tian, Juanjuan Bi, Ning Lu, Chen Chen, Shijia Yan, Ang Li, Luyun Wang, Xiang Li, Kangdong Liu, Zigang Dong
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116603- (2024)
Novel strategies in intratumoral injection and emerging immunotherapies have heralded a new era of precise cancer treatments. The affinity of SARS-CoV-2 to ACE2 receptors, a feature which facilitates virulent human infection, is leveraged in this res
Externí odkaz:
https://doaj.org/article/aefbc0c62aaf49d9bb5c6b524f56288f