Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kang-Sup Shim"'
Autor:
Alice H. Hsu, Michelle A. Lum, Kang-Sup Shim, Peter J. Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Yuri M. Sheinin, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. Black
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 655-669 (2018)
Summary: Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings p
Externí odkaz:
https://doaj.org/article/70af1efa537b465a82f8857a0e61398f
Autor:
Peter J. Frederick, Alice H. Hsu, Gustavo Leone, Takiko Daikoku, Subodh M. Lele, Sudhansu K. Dey, Kang Sup Shim, Adrian R. Black, Michelle A. Lum, Baojiang Chen, Carl Morrison, Jennifer D. Black, Yuri Sheinin
Publikováno v:
Cell reports
Cell Reports, Vol 24, Iss 3, Pp 655-669 (2018)
Cell Reports, Vol 24, Iss 3, Pp 655-669 (2018)
SUMMARY Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings pr
Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5
Autor:
Jong Kook Park, Yong Peng, Ri Cui, Hui-Lung Sun, Jeong Su Oh, Tae Jin Lee, Ji Hoon Lee, Ju Hwan Cho, Esmerina Tili, Ju Hee Lee, Hosung Sim, Hiroshi Nakanishi, Young-Jun Jeon, Kang Sup Shim, Bong Hwan Sung, Sung Hak Kim, Taewan Kim, Paolo Fadda, Huijun Wei, Carlo M. Croce, Sang Bong Ko, Hansjuerg Alder, Man Il Huh, Zhenghua Luo
Publikováno v:
Proceedings of the National Academy of Sciences. 111:4173-4178
Significance Many cancer-associated variants have been found in the 8q24.21 region harboring enhancer activity. However, the functional mechanism of the variants is not clear due to the lack of protein-coding genes in the region and no significant co
Autor:
Ravindra Amunugama, Yu Luo, Ralf Bundschuh, Kang Sup Shim, Yujiong He, Jack D. Griffith, Richard Fishel, Robert A. Forties, Smaranda Willcox
Publikováno v:
Journal of Biological Chemistry. 287:8724-8736
RAD51 mediates homologous recombination by forming an active DNA nucleoprotein filament (NPF). A conserved aspartate that forms a salt bridge with the ATP γ-phosphate is found at the nucleotide-binding interface between RAD51 subunits of the NPF kno
Autor:
Helen M. Chamberlin, Thac Pham, Paul J. Goodfellow, Robert Pilarski, David E. Cohn, Charles L. Shapiro, Onur Egriboz, Adrian A. Suarez, Julie A. Wallace, Raleigh D. Kladney, Xing Tang, Changxian Shen, Gustavo Leone, Cynthia Timmers, Maria C. Cuitiño, Chelsea K. Martin, Kang Sup Shim, Michael C. Ostrowski, David M. O'Malley, Arunima Srivastava, Vincenzo Coppola, Thierry Pécot, Diego H. Castrillon, Morag Park, Soledad Fernandez, Hui Wang, Matthew K. Karikomi, Melissa J. Mauntel, Floor J. Backes, Thomas J. Rosol, Krista M. D. La Perle, Erin Macrae, Xiaokui Mo, Enrico Caserta, Christopher Koivisto, Sarmila Majumder, Lianbo Yu
Publikováno v:
Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2015, ⟨10.1101/gad.262568.115⟩
Genes and Development, 2015, ⟨10.1101/gad.262568.115⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2015, ⟨10.1101/gad.262568.115⟩
Genes and Development, 2015, ⟨10.1101/gad.262568.115⟩
Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linked to increased PI3K–AKT signaling, enhanced organismal growth, and cancer development. Here we generated and analyzed Pten knock-in mice harboring a C2 domain m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0862c8e95b0a35dc23d47ede1a525acb
https://hal.inria.fr/hal-01244933
https://hal.inria.fr/hal-01244933
Publikováno v:
Journal of Biological Chemistry. 277:14434-14442
Adenosine nucleotides affect the ability of RecA·single-stranded DNA (ssDNA) nucleoprotein filaments to cooperatively assume and maintain an extended structure that facilitates DNA pairing during recombination. Here we have determined that ADP and A
Publikováno v:
Journal of Biological Chemistry. 276:33011-33018
Exonucleolytic degradation of DNA is an essential part of many DNA metabolic processes including DNA mismatch repair (MMR) and recombination. Human exonuclease I (hExoI) is a member of a family of conserved 5' --3' exonucleases, which are implicated
Publikováno v:
Cancer. 85:554-561
BACKGROUND Transforming growth factor-β1 (TGF-β1) acts as a potent inhibitor of cell growth and tumor progression but loss of this negative regulation can contribute to tumor development. Some studies have reported an association between disease pr
Autor:
Adrian R. Black, Takiko Daikoku, Peter J. Frederick, Gustavo Leone, Alice H. Hsu, Kathryn J. Curry, Baojiang Chen, Kang-Sup Shim, Sudhansu K. Dey, Jennifer D. Black, Carl Morrison, Subodh M. Lele
Publikováno v:
Cancer Research. 76:189-189
Endometrial cancer (EC) is the most common gynecological malignancy and the fourth leading cancer in women in the United States. Hyperactivation of the PI3K/AKT pathway is observed in ∼90% of EC cases and this pathway is the most prominent driver o
Publikováno v:
SPIE Proceedings.
An Fourier Transform Infra-Red(FTIR) spectrometry has played an significant role in a variety of fields in recent years. In particular, FTIR spectrometer technology has been adopted in passive remote sensing system to predict detection probabilities