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Akademický článek

Large animal model species in pluripotent stem cell therapy research and development for retinal diseases: a systematic review

Autor: Julia-Sophia Bellingrath, Kang V. Li, Kanza Aziz, Jessica M. Izzi, Ying V. Liu, Mandeep S. Singh

Publikováno v: Frontiers in Ophthalmology, Vol 4 (2024)

AimRetinal cell therapy modalities, in the category of advanced therapy medicinal products (ATMPs), are being developed to target several retinal diseases. Testing in large animal models (LAMs) is a crucial step in translating retinal ATMPs into clin

Externí odkaz: https://doaj.org/article/f35845fd23484a5f84c2edb74214064c

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Akademický článek

OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health

Autor: Michael Carlson, Sanghoon Kim, Silvia Aparicio-Domingo, Kang V. Li, Ben Puig, Subrata Batabyal, M. Valeria Canto-Soler, Samarendra Mohanty

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Inherited retinal disorders and dry age-related macular degeneration are characterized by the degeneration and death of different types of photoreceptors at different rate and locations. Advancement of new therapeutic interventions such as o

Externí odkaz: https://doaj.org/article/067580129f8742368e97f9d3e62e6353

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Akademický článek

Progress of clinical therapies for dry age-related macular degeneration

Autor: Rhianna Rubner, Kang V. Li, M. Valeria Canto-Soler

Publikováno v: International Journal of Ophthalmology, Vol 15, Iss 1, Pp 157-166 (2022)

Dry age-related macular degeneration (AMD) is a progressive blinding disease that currently affects millions of people worldwide with no successful treatment available. Significant research efforts are currently underway to develop therapies aimed at

Externí odkaz: https://doaj.org/article/e87881c6f7424a35800aa3defeeb0966

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Akademický článek

A Surgical Kit for Stem Cell-Derived Retinal Pigment Epithelium Transplants: Collection, Transportation, and Subretinal Delivery

Autor: Kang V. Li, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Carson Petrash, Hannah Cobb, Conan Chen, M. Valeria Canto-Soler, Marc T. Mathias

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Transplantation of stem cell-derived retinal pigment epithelium (RPE) cells is a promising potential therapy for currently incurable retinal degenerative diseases like advanced dry age-related macular degeneration. In this study, we designed a set of

Externí odkaz: https://doaj.org/article/df5e9d034c0a4fa38b6d21886713bd0a

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Akademický článek

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Autor: Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler

Publikováno v: Journal of Extracellular Vesicles, Vol 10, Iss 13, Pp n/a-n/a (2021)

Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD pro

Externí odkaz: https://doaj.org/article/f4461325f8d6451f97d6779225925a12

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