Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kang Jian Zhang"'
Autor:
Rong Zhang, Min Liu, Xiaoxia Li, Feng Liu, Yanqiu Liu, Wenting Zhong, Hongwei Liu, Yandong He, Xuhong Huang, Junjia Tao, Yuanzhou Shan, Hafiz Khuram Raza, Xue-ping Cao, Yuan-yuan Yang, Ruimei Li, Xian-long Fang, Kang-jian Zhang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Objective To evaluate the safety and preliminary efficacy of YSCH-01 (Recombinant L-IFN adenovirus) in subjects with advanced solid tumors.Methods In this single-center, open-label, investigator-initiated trial of YSCH-01, 14 patients with advanced s
Externí odkaz:
https://doaj.org/article/fb45b65080ba48b69a0ddfc121103402
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Systemic administration of oncolytic adenovirus for cancer therapy is still a challenge. Mesenchymal stem cells as cell carriers have gained increasing attention in drug delivery due to their excellent tumor tropism, immunosuppres
Externí odkaz:
https://doaj.org/article/93efe1db04284b769ce687734616ca3d
Autor:
Yuan-Qin Yang, Wen-Jie Dong, Xiao-Fei Yin, Yan-Ni Xu, Yu Yang, Jiao-Jiao Wang, Su-Jing Yuan, Jing Xiao, Jonathan Howard DeLong, Liang Chu, Hai-Neng Xu, Xiu-Mei Zhou, Ru-Wei Wang, Ling Fang, Xin-Yuan Liu, Kang-Jian Zhang
Publikováno v:
Protein & Cell, Vol 7, Iss 7, Pp 538-543 (2016)
Externí odkaz:
https://doaj.org/article/d37b5ca6b4704844af5e565918a69cbc
Autor:
Serge Y. Fuchs, Xin-Yuan Liu, Da-Cheng Wang, Guang-Wen Wei, Rong-Bing Guo, Yuliya V. Katlinskaya, Kanstantsin V. Katlinski, Liang Chu, Hai-Neng Xu, Shuai Wu, Jing Xiao, Xian-Long Fang, Su-Jing Yuan, Xi-Jun Liu, Lie-Yang Chen, Yan-Ni Xu, Hui-Ling Li, Yuan-Qin Yang, Xiao-Fei Yin, Kang-Jian Zhang
Supplementary methods, tables, figures and legends to figures Supplementary Figure 1. The structure of AB loops for sIFN-I and IFNα-2b and comparison on the sequences for sIFN-I and IFNα-21. Supplementary Figure 2. Quantification of phosphorylaiton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d7d534bf96dd0984a42cde1954afaf
https://doi.org/10.1158/1078-0432.22466456.v1
https://doi.org/10.1158/1078-0432.22466456.v1
Autor:
Serge Y. Fuchs, Xin-Yuan Liu, Da-Cheng Wang, Guang-Wen Wei, Rong-Bing Guo, Yuliya V. Katlinskaya, Kanstantsin V. Katlinski, Liang Chu, Hai-Neng Xu, Shuai Wu, Jing Xiao, Xian-Long Fang, Su-Jing Yuan, Xi-Jun Liu, Lie-Yang Chen, Yan-Ni Xu, Hui-Ling Li, Yuan-Qin Yang, Xiao-Fei Yin, Kang-Jian Zhang
Purpose: Antiproliferative, antiviral, and immunomodulatory activities of endogenous type I IFNs (IFN1) prompt the design of recombinant IFN1 for therapeutic purposes. However, most of the designed IFNs exhibited suboptimal therapeutic efficacies aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3b4d772358fb107d6a9cddd1ecf806
https://doi.org/10.1158/1078-0432.c.6526319
https://doi.org/10.1158/1078-0432.c.6526319
Publikováno v:
Immunotherapy Open Access.
This paper is to emphasize the higher antitumor effect of IL-24, because it can make the complete elimination of the xenograft tumor. Another important point in this paper is to introduce a strategy for essentially complete eradication all the xenogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe271a021b2954ab883c32a6ef191d6
https://doi.org/10.4172/2471-9552.1000133
https://doi.org/10.4172/2471-9552.1000133
Publikováno v:
Single Cell Biology. 5
PD-L1, also known as CD274 or B7-H1, is a major immune checkpoint protein . The binding of PD-L1 to its receptor PD-1 induces an inhibitory signal that suppresses the immune response by several mechanisms such as inhibiting the proliferation of CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c32618c5c14ff69a8f7b9c2134a5eb
https://doi.org/10.4172/2168-9431.1000146
https://doi.org/10.4172/2168-9431.1000146
Autor:
Xiao Yuan Jia, Yu Mei Wu, Jing Qian, Kang Jian Zhang, Guo Liang Xie, Yuan Tan, Yi Gang Wang, Xinyuan Liu, Lian Li Xiao
Publikováno v:
Cancer Biology & Therapy. 10:242-250
IL-24 (interleukin-24) is a promising, multi-functional anti-cancer agent able to selectively induce tumor cell apoptosis while sparing normal cells. Additionally, IL-24 can enhance the immune response to tumors and suppress tumor angiogenesis. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102e4630616506a81ca72c5cdef93ef3
https://doi.org/10.4161/cbt.10.3.12308
https://doi.org/10.4161/cbt.10.3.12308
Autor:
Xiu-Mei Zhou, Xi-Jun Liu, Hai Jiang, Kang-Jian Zhang, Wei Li, Jing Zhang, Na Niu, Yan-Ping Kong
Publikováno v:
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 37:627-634
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0d0381224fe5522b6af900a8b3d33f
https://doi.org/10.3724/sp.j.1206.2009.00575
https://doi.org/10.3724/sp.j.1206.2009.00575
Autor:
Rui Cheng Wei, Yu Mei Wu, Xue Tian Yue, Xinyuan Liu, Kang Jian Zhang, Gongchu Li, Su Yang Zhong, Xin Cao, Yigang Wang
Publikováno v:
Human Gene Therapy. 20:818-830
Interleukin (IL)-24 is an excellent therapeutic gene for cancer therapy. In this work, IL-24 was inserted into Ad.sp-E1A(Delta24), an oncolytic adenovirus with a 24-bp deletion in the E1A gene, which was driven by the survivin promoter to form Ad.sp-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b3dc6afb618ccbaccdecc0088246e5
https://doi.org/10.1089/hum.2008.205
https://doi.org/10.1089/hum.2008.205