Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kang Chieh Huang"'
Autor:
Sailee S. Lavekar, Jason M. Hughes, Cátia Gomes, Kang-Chieh Huang, Jade Harkin, Scott G. Canfield, Jason S. Meyer
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Glaucoma is a neurodegenerative disease that results in the degeneration of retinal ganglion cells (RGCs) and subsequent loss of vision. While RGCs are the primary cell type affected in glaucoma, neighboring cell types selectively modulate R
Externí odkaz:
https://doaj.org/article/4ae8ae1c7ec641838f1c5ce414cd3aab
Autor:
Kang-Chieh Huang, Cátia Gomes, Yukihiro Shiga, Nicolas Belforte, Kirstin B. VanderWall, Sailee S. Lavekar, Clarisse M. Fligor, Jade Harkin, Shelby M. Hetzer, Shruti V. Patil, Adriana Di Polo, Jason S. Meyer
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-22 (2024)
Abstract The ability to derive retinal ganglion cells (RGCs) from human pluripotent stem cells (hPSCs) has led to numerous advances in the field of retinal research, with great potential for the use of hPSC-derived RGCs for studies of human retinal d
Externí odkaz:
https://doaj.org/article/35e2ff994a3b45f6abf25b65705e90fc
Autor:
Sailee S. Lavekar, Jade Harkin, Melody Hernandez, Cátia Gomes, Shruti Patil, Kang-Chieh Huang, Shweta S. Puntambekar, Bruce T. Lamb, Jason S. Meyer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and neurodegeneration. The retina is an extension of the central
Externí odkaz:
https://doaj.org/article/5b8a057306ec4cc9b99937e3d9a53d30
Autor:
Michelle Surma, Kavitha Anbarasu, Sayanta Dutta, Leonardo J. Olivera Perez, Kang-Chieh Huang, Jason S. Meyer, Arupratan Das
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Human retinal ganglion cells generate mitochondria under mitochondrial damage conditions, with TBK1 inhibition activating mitochondrial biogenesis and neuroprotective effects in both WT and glaucomatous RGC neurons.
Externí odkaz:
https://doaj.org/article/7d7c00d2407a434d848be0641d37b094
Autor:
Chih-Hung Chuang, Tian-Lu Cheng, Wei-Chun Chen, Yi-Jung Huang, Hsin-Ell Wang, Yen-Chen Lo, Yuan-Chin Hsieh, Wen-Wei Lin, Ya-Ju Hsieh, Chien-Chih Ke, Kang-Chieh Huang, Jin-Ching Lee, Ming-Yii Huang
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Hepatitis C virus (HCV) NS3/4A protease is an attractive target for direct-acting antiviral agents. Real-time tracking of the NS3/4A protease distribution and activity is useful for clinical diagnosis and disease management. However, no approach has
Externí odkaz:
https://doaj.org/article/64a694c6a566471282dc43df3469ce6b
Autor:
Harkin, Jade, Peña, Kiersten H., Gomes, Cátia, Hernandez, Melody, Lavekar, Sailee S., So, Kaman, Lentsch, Kelly, Feder, Elyse M., Morrow, Sarah, Kang-Chieh Huang, Tutrow, Kaylee D., Morris, Ann, Chi Zhang, Meyer, Jason S.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/18/2024, Vol. 121 Issue 25, p1-12, 28p
Autor:
Kang-Chieh Huang, Mong-Lien Wang, Shih-Jen Chen, Jean-Cheng Kuo, Won-Jing Wang, Phan Nguyen Nhi Nguyen, Karl J. Wahlin, Jyh-Feng Lu, Audrey A. Tran, Michael Shi, Yueh Chien, Aliaksandr A. Yarmishyn, Ping-Hsing Tsai, Tien-Chun Yang, Wann-Neng Jane, Chia-Ching Chang, Chi-Hsien Peng, Thorsten M. Schlaeger, Shih-Hwa Chiou
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 906-923 (2019)
Summary: X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated human induced pluripotent stem cells (hiPSCs) from patients to study XLRS in a 3D ret
Externí odkaz:
https://doaj.org/article/b9f017c6d6624217abb79abd14c148e3
Autor:
Chi-Hsien Peng, Kang-Chieh Huang, Huai-En Lu, Shih-Han Syu, Aliaksandr A. Yarmishyn, Jyh-Feng Lu, Waradee Buddhakosai, Tai-Chi Lin, Chih-Chien Hsu, De-Kuang Hwang, Chia-Ning Shen, Shih-Jen Chen, Shih-Hwa Chiou
Publikováno v:
Stem Cell Research, Vol 29, Iss , Pp 152-156 (2018)
X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy manifested as splitting of anatomical layers of retina. In this report, we generated a patient-specific induced pluripotent stem cell (iPSC) line, TVGH-iPSC-013-05, from the per
Externí odkaz:
https://doaj.org/article/18b33a83003047058c692d2155a09f01
Autor:
Cátia Gomes, Kirstin B. VanderWall, Yanling Pan, Xiaoyu Lu, Sailee S. Lavekar, Kang-Chieh Huang, Clarisse M. Fligor, Jade Harkin, Chi Zhang, Theodore R. Cummins, Jason S. Meyer
Publikováno v:
Stem Cell Reports. 17:1636-1649
Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although studies often explore cell-autonomous aspects of RGC neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597a180ddd017de54483c846cee0261a
https://doi.org/10.1016/j.stemcr.2022.05.006
https://doi.org/10.1016/j.stemcr.2022.05.006
Autor:
Kang-Chieh Huang, Cátia Gomes, Yukihiro Shiga, Nicolas Belforte, Kirstin B. VanderWall, Sailee S. Lavekar, Clarisse M. Fligor, Jade Harkin, Adriana Di Polo, Jason S. Meyer
Autophagy dysfunction has been associated with several neurodegenerative diseases including glaucoma, characterized by the degeneration of retinal ganglion cells (RGCs). However, the mechanisms by which autophagy dysfunction promotes RGC damage remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3178c710022f73c5afb17ec353643cf8
https://doi.org/10.1101/2023.01.04.522687
https://doi.org/10.1101/2023.01.04.522687
