Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Kang‐Yell Choi"'
Autor:
Eunhwan Kim, Seol Hwa Seo, Yumi Hwang, Yeong Chan Ryu, Heejene Kim, Kyoung-Mi Lee, Jin Woo Lee, Kwang Hwan Park, Kang-Yell Choi
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 8, Pp 1770-1782 (2023)
Abstract Diabetic wound healing, including diabetic foot ulcer (DFU), is a serious complication of diabetes. Considering the complexity of DFU development, the identification of a factor that mediates multiple pathogeneses is important for treatment.
Externí odkaz:
https://doaj.org/article/bf1b9e96a25e44079ed61f50ea638817
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Obesity has become a major risk factor for developing metabolic diseases, including insulin resistance, type 2 diabetes, and hypertension. Growing pieces of evidence indicate that the Wnt/β-catenin signaling pathway plays an important role
Externí odkaz:
https://doaj.org/article/fd83b9905c8143d9b9e9b7bde7b1e14b
Autor:
Minguen Yoon, Heejene Kim, Heewon Shin, HeeYang Lee, Min-Jeong Kang, Sung-Hye Park, Gyoonhee Han, YoungSoo Kim, Kang-Yell Choi
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106836- (2023)
Alzheimer’s disease (AD) is the most prevalent type of dementia and is characterized by cognitive deficits and accumulation of pathological plaques. Owing to the complexity of AD development, paradigms for AD research and drug discovery have shifte
Externí odkaz:
https://doaj.org/article/e9a6c1e3fcbe4d8fb99c697192e34fbb
Autor:
Eunhwan Kim, Yumi Hwang, Heejene Kim, Geon-Uk Kim, Yeong Chan Ryu, Minguen Yoon, Kang-Yell Choi
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2028 (2023)
Cutaneous wound healing is a complex and dynamic process with high energy demand. The activation of glycolysis is essential for restoring the structure and function of injured tissues in wounds. Pyruvate kinase M2 (PKM2) is an enzyme that plays a cru
Externí odkaz:
https://doaj.org/article/fefb42a0bca54133bc0d191b5a2dbc6d
Autor:
Seol Hwa Seo, Eunhwan Kim, Soung‐Hoon Lee, Yong‐ho Lee, Dai Hoon Han, Hyesun Go, Je Kyung Seong, Kang‐Yell Choi
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Background Metabolic diseases, including type 2 diabetes, have long been considered incurable, chronic conditions resulting from a variety of pathological conditions in obese patients. Growing evidence suggests the Wnt/β‐catenin pathway i
Externí odkaz:
https://doaj.org/article/cfc2fa4033174e65bb724473a93971a1
Autor:
Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Tomohiro Mizutani, Dong-Woo Kang, Jong-Chan Park, Tae Il Kim, Hans Clevers, Kang-Yell Choi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The relative enrichment of cancer stem cells after treatment results in tumour recurrence. Here, the authors show a mechanism where p53 induces WNT3, which increases the number of colorectal cancer stem cells following treatment of 5-fluorouracil.
Externí odkaz:
https://doaj.org/article/734b08cd776a44bf9b6930273cd2ce5d
Autor:
Won-Ji Ryu, Jeong Dong Lee, Jong-Chan Park, Pu-Hyeon Cha, Yong-Hee Cho, Jee Ye Kim, Joo Hyuk Sohn, Soonmyung Paik, Kang-Yell Choi
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 5, Pp 832-842 (2020)
Breast cancer: Dual pathway blockade shrinks aggressive tumors The triple-negative breast cancer (TNBC), a highly aggressive form of breast cancer may be susceptible to drug therapy that targets two critical signaling pathways, one that governs cell
Externí odkaz:
https://doaj.org/article/4bb29888b7d9430e820c489b57c846cf
Autor:
Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Dong-Kyu Kwak, Jaebeom Cho, Dong Woo Kang, Ho-Young Lee, Kang-Yell Choi
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background Cancer stem cells (CSCs), the major driver of tumorigenesis, is a sub-population of tumor cells responsible for poor clinical outcomes. However, molecular mechanism to identify targets for controlling CSCs is poorly understood. Me
Externí odkaz:
https://doaj.org/article/fec1a494aab44099abcc3d9a9decb3ac
Autor:
Yeong Chan Ryu, Jiyeon Park, You-Rin Kim, Sehee Choi, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Gyoonhee Han, Soung-Hoon Lee, Kang-Yell Choi
Publikováno v:
Cells, Vol 12, Iss 4, p 555 (2023)
The number of people suffering from hair loss is increasing, and hair loss occurs not only in older men but also in women and young people. Prostaglandin D2 (PGD2) is a well-known alopecia inducer. However, the mechanism by which PGD2 induces alopeci
Externí odkaz:
https://doaj.org/article/e748a3a88dce4e9dbe31c94e1e347d31
Autor:
Yeong Chan Ryu, You-Rin Kim, Jiyeon Park, Sehee Choi, Won-Ji Ryu, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Gyoonhee Han, Soung-Hoon Lee, Kang-Yell Choi
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2774 (2022)
Hair follicle stem cells (HFSCs) utilize glycolytic metabolism during their activation and anagen induction. However, the role of pyruvate kinase M2 (PKM2), which catalyzes the final step of glycolysis, in hair regeneration has not been elucidated. I
Externí odkaz:
https://doaj.org/article/fc862ab20e6c48098de86778b063494c