The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

Autor: Weng, Hengyou, Huang, Feng, Yu, Zhaojin, Chen, Zhenhua, Prince, Emily, Kang, Yalin, Zhou, Keren, Li, Wei, Hu, Jiacheng, Fu, Chen, Aziz, Tursunjan, Li, Hongzhi, Li, Jingwen, Yang, Ying, Han, Li, Zhang, Subo, Ma, Yuelong, Sun, Mingli, Wu, Huizhe, Zhang, Zheng, Wunderlich, Mark, Robinson, Sean, Braas, Daniel, Hoeve, Johanna ten, Zhang, Bin, Marcucci, Guido, Mulloy, James C., Zhou, Keda, Tao, Hong-Fang, Deng, Xiaolan, Horne, David, Wei, Minjie, Huang, Huilin, Chen, Jianjun

Publikováno v: In Cancer Cell 12 December 2022 40(12):1566-1582

Irradiation-Induced Activated Microglia Affect Brain Metastatic Colonization of NSCLC Cells via miR-9/CDH1 Axis.

Autor: Jin, Yu (AUTHOR), Kang, Yalin (AUTHOR), Peng, Xiaohong (AUTHOR), Yang, Li (AUTHOR), Li, Qianxia (AUTHOR), Mei, Qi (AUTHOR), Chen, Xinyi (AUTHOR), Hu, Guangyuan (AUTHOR), Tang, Yang (AUTHOR), Yuan, Xianglin (AUTHOR)

Publikováno v: OncoTargets & Therapy. Mar2021, Vol. 14, p1911-1922. 12p.

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NAT10-mediated mRNA N ⁴ -acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia.

Autor: Zhang S; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Huang F; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China.; Bioland Laboratory, Guangzhou, China., Wang Y; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China., Long Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Li Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Kang Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Gao W; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China.; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Zhang X; Bioland Laboratory, Guangzhou, China.; Shantou University Medical College, Shantou, China., Wen Y; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China., Wang Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Pan L; Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.; Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, China., Xia Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Yang Z; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Yang Y; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China.; Bioland Laboratory, Guangzhou, China., Mo H; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China.; Bioland Laboratory, Guangzhou, China., Li B; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China.; Bioland Laboratory, Guangzhou, China., Hu J; Bioland Laboratory, Guangzhou, China.; Shantou University Medical College, Shantou, China., Song Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhang S; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China., Dong S; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Du X; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Li Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Liao W; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Gao Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhang Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen H; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China.; Bioland Laboratory, Guangzhou, China., Liang Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen J; Department of Systems Biology & Center for RNA Biology and Therapeutics, Beckman Research Institute of City of Hope, Monrovia, CA, USA., Weng H; Guangzhou National Laboratory, The First Affiliated Hospital, The Fifth Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, China. weng_hengyou@gzlab.ac.cn.; Bioland Laboratory, Guangzhou, China. weng_hengyou@gzlab.ac.cn., Huang H; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. huanghl1@sysucc.org.cn.

Publikováno v: Nature cell biology [Nat Cell Biol] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.