Central Mechanisms Mediating Thrombospondin-4-induced Pain States

Autor: Eric Y. Chang, Edward Perez-Reyes, Doo-sik Kim, Z. David Luo, Xia Zhang, Nian Gong, Guoping Feng, Kelli Sharp, John W. Park, Cagla Eroglu, Iuliia Vitko, Ben A. Barres, Dongqing Wang, Kang-Wu Li, Chun-Yi Zhou, Frank Zaucke, Benjamin Vo, Yanhui Peter Yu, Oswald Steward

Publikováno v: Park, J; Yu, YP; Zhou, C-Y; Li, K-W; Wang, D; Chang, E; et al.(2016). Central Mechanisms Mediating Thrombospondin-4-induced Pain States. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(25), 13335-13348. doi: 10.1074/jbc.M116.723478. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5nn786t1
The Journal of biological chemistry, vol 291, iss 25

Peripheral nerve injury induces increased expression of thrombospondin-4 (TSP4) in spinal cord and dorsal root ganglia that contributes to neuropathic pain states through unknown mechanisms. Here, we test the hypothesis that TSP4 activates its recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f515f631fcd467b41eaed7ffb8ddc431
https://doi.org/10.1074/jbc.m116.723478

Trigeminal nerve injury-induced thrombospondin-4 up-regulation contributes to orofacial neuropathic pain states in a rat model

Autor: Doo-sik Kim, Z.D. Luo, Frank Zaucke, Kang-Wu Li

Publikováno v: European Journal of Pain. 18:489-495

Background Injury to the trigeminal nerve often results in the development of chronic pain states including tactile allodynia, or hypersensitivity to light touch, in orofacial area, but its underlying mechanisms are poorly understood. Peripheral nerv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcdfe458351bffa5a826b983b11b8bdd
https://doi.org/10.1002/j.1532-2149.2013.00396.x

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A novel analgesic isolated from a traditional Chinese medicine

Autor: Mi Kyeong Kim, Z. David Luo, Olivier Civelli, Guang-Bo Ge, Ling Yang, Zhiwei Wang, M. Julia García-Fuster, Xinmiao Liang, Zhimou Guo, Lien Wang, Chaoran Wang, Yan Zhang, Xiuli Zhang, Kang-Wu Li, Benjamin Vo, Gregory S. Parks, Emiliana Borrelli, Yanxiong Ke

Publikováno v: Current biology : CB, vol 24, iss 2
Zhang, Y; Wang, C; Wang, L; Parks, GS; Zhang, X; Guo, Z; et al.(2014). A novel analgesic isolated from a traditional Chinese medicine. Current Biology, 24(2), 117-123. doi: 10.1016/j.cub.2013.11.039. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6dw9k51d

Background Current pain management is limited, in particular, with regard to chronic pain. In an attempt to discover novel analgesics, we combined the approach developed to characterize traditional Chinese medicine (TCM), as part of the "herbalome" p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819d9cf6b191978405a35ff62f9e06da
https://escholarship.org/uc/item/6dw9k51d

Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states

Autor: Chun Yi Zhou, Amin Boroujerdi, Kelli Sharp, Michael Corpe, Yanhui Peter Yu, Z. David Luo, Frank Zaucke, John Park, Doo Sik Kim, Zao C. Xu, Cagla Eroglu, Xia Zhang, Ping Deng, Ben A. Barres, Kang Wu Li, Joshua Lee, Oswald Steward

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(26)

Neuropathic pain is a common cause of pain after nerve injury, but its molecular basis is poorly understood. In a post-genechip microarray effort to identify new target genes contributing to neuropathic pain development, we report here the characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8265ce746a2d66a310950ee1ad3286
https://pubmed.ncbi.nlm.nih.gov/22745497