Compatibility rules of human enhancer and promoter sequences

Autor: Bergman, Drew T., Jones, Thouis R., Liu, Vincent, Ray, Judhajeet, Jagoda, Evelyn, Siraj, Layla, Kang, Helen Y., Nasser, Joseph, Kane, Michael, Rios, Antonio, Nguyen, Tung H., Grossman, Sharon R., Fulco, Charles P., Lander, Eric S., Engreitz, Jesse M.

Publikováno v: Nature; 20240101, Issue: Preprints p1-9, 9p

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Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart.

Autor: Ma XR; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Conley SD; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Kosicki M; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Bredikhin D; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Cui R; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tran S; Department of Pediatrics, Stanford University, Stanford, CA, USA., Sheth MU; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA., Qiu WL; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Chen S; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Kundu S; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Kang HY; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Current address: PhD Program in Computational and Systems Biology, MIT, Cambridge, MA, USA., Amgalan D; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Maternal and Child Health Research Institute, Stanford University, Stanford, CA, USA., Munger CJ; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Duan L; Department of Pediatrics, Stanford University, Stanford, CA, USA., Dang K; Department of Pediatrics, Stanford University, Stanford, CA, USA., Rubio OM; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Pediatrics, Stanford University, Stanford, CA, USA., Kany S; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany., Zamirpour S; School of Medicine, University of California San Francisco, San Francisco, CA, USA., DePaolo J; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Padmanabhan A; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Olgin J; Division of Cardiology, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Damrauer S; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Andersson R; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Gu M; Center for Stem Cell and Organoid Medicine, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati School of Medicine, Cincinnati, OH, USA., Priest JR; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Tenaya Therapeutics, South San Francisco, CA, USA., Quertermous T; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Medicine, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA., Qiu X; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA.; Maternal and Child Health Research Institute, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Stanford Bio-X, Stanford University, Stanford, CA, USA., Rabinovitch M; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Vera Moulton Wall Center for Pulmonary Vascular Diseases, Stanford University, Stanford, CA, USA., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; School of Natural Sciences, University of California, Merced, Merced, CA, USA., Pennacchio L; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA, 94720, USA., Kundaje A; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Glass IA; Maternal and Child Health Research Institute, Stanford University, Stanford, CA, USA.; Department of Pediatrics and Medicine, University of Washington School of Medicine, Seattle, WA, USA., Gifford CA; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Maternal and Child Health Research Institute, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA., Pirruccello JP; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Cardiology, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, CA, USA.; Bakar Computation Health Sciences Institute, University of California, San Francisco, CA, USA., Goodyer WR; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Maternal and Child Health Research Institute, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA., Engreitz JM; Basic Science and Engineering (BASE) Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Maternal and Child Health Research Institute, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.