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Akademický článek

Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors.

Autor: Bobrovs R; Latvian Institute of Organic Synthesis, Riga, Latvia., Bolsakova J; Latvian Institute of Organic Synthesis, Riga, Latvia., Buitrago JAR; Latvian Institute of Organic Synthesis, Riga, Latvia., Varaceva L; Latvian Institute of Organic Synthesis, Riga, Latvia., Skvorcova M; Latvian Institute of Organic Synthesis, Riga, Latvia., Kanepe I; Latvian Institute of Organic Synthesis, Riga, Latvia., Rudnickiha A; Latvian Institute of Organic Synthesis, Riga, Latvia., Parisini E; Latvian Institute of Organic Synthesis, Riga, Latvia.; Department of Chemistry 'G. Ciamician', University of Bologna, Bologna, Italy., Jirgensons A; Latvian Institute of Organic Synthesis, Riga, Latvia.

Publikováno v: PloS one [PLoS One] 2024 Apr 01; Vol. 19 (4), pp. e0296995. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).

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Akademický článek

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library.

Autor: Bolsakova J; Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia., Bobrovs R; Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia., Varacheva L; Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia., Rudnickiha A; Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia., Kanepe I; Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia., Parisini E; Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.; Department of Chemistry 'G. Ciamician', University of Bologna, 40126 Bologna, Italy., Jirgensons A; Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Dec 14; Vol. 15 (1), pp. 76-80. Date of Electronic Publication: 2023 Dec 14 (Print Publication: 2024).

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Akademický článek

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors.

Autor: Bobrovs R; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Drunka L; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Kanepe I; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Jirgensons A; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Caflisch A; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland., Salvalaglio M; Thomas Young Centre and Department of Chemical Engineering, University College London, London WC1E 7JE, United Kingdom., Jaudzems K; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2023 Nov 13; Vol. 63 (21), pp. 6890-6899. Date of Electronic Publication: 2023 Oct 06.

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Akademický článek

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors.

Autor: Bobileva O; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia., Bobrovs R; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia., Sirma EE; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia., Kanepe I; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia., Bula AL; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia., Patetko L; Faculty of Biology, University of Latvia, LV-1004 Riga, Latvia., Ramata-Stunda A; Faculty of Biology, University of Latvia, LV-1004 Riga, Latvia., Grinberga S; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia., Jirgensons A; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia., Jaudzems K; Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 12; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 12.

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Akademický článek

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Akademický článek

Exploring Aspartic Protease Inhibitor Binding to Design Selective Antimalarials.

Autor: Bobrovs R; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Basens EE; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Drunka L; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Kanepe I; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Matisone S; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Velins KK; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Andrianov V; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Leitis G; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Zelencova-Gopejenko D; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Rasina D; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Jirgensons A; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia., Jaudzems K; Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV1006, Latvia.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2022 Jul 11; Vol. 62 (13), pp. 3263-3273. Date of Electronic Publication: 2022 Jun 17.

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Akademický článek

Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening.

Autor: Bobrovs R; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia., Kanepe I; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia., Narvaiss N; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia., Patetko L; Faculty of Biology, University of Latvia, Jelgavas 1, LV-1004 Riga, Latvia., Kalnins G; Latvian Biomedical Research and Study Centre, Ratsupites 1 k1, LV-1067 Riga, Latvia., Sisovs M; Latvian Biomedical Research and Study Centre, Ratsupites 1 k1, LV-1067 Riga, Latvia., Bula AL; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia., Grinberga S; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia., Boroduskis M; Faculty of Biology, University of Latvia, Jelgavas 1, LV-1004 Riga, Latvia., Ramata-Stunda A; Faculty of Biology, University of Latvia, Jelgavas 1, LV-1004 Riga, Latvia., Rostoks N; Faculty of Biology, University of Latvia, Jelgavas 1, LV-1004 Riga, Latvia., Jirgensons A; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia., Tars K; Latvian Biomedical Research and Study Centre, Ratsupites 1 k1, LV-1067 Riga, Latvia., Jaudzems K; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2021 Nov 30; Vol. 14 (12). Date of Electronic Publication: 2021 Nov 30.

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