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Macrophage PI3K gamma Drives Pancreatic Ductal Adenocarcinoma Progression

Autor: Kaneda, MM, Cappello, P, Nguyen, AV, Ralainirina, N, Hardamon, CR, Foubert, P, Schmid, MC, Sun, P, Mose, E, Bouvet, M, Lowy, AM, Valasek, MA, Sasik, R, Novelli, F, Hirsch, E, Varner, JA

Publikováno v: Kaneda, MM; Cappello, P; Nguyen, AV; Ralainirina, N; Hardamon, CR; Foubert, P; et al.(2016). Macrophage PI3K gamma Drives Pancreatic Ductal Adenocarcinoma Progression. CANCER DISCOVERY, 6(8), 870-885. doi: 10.1158/2159-8290.CD-15-1346. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7rs726zj

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a low 5-year survival rate, yet new immunotherapeutic modalities may offer hope for this and other intractable cancers. Here, we report that inhibitory targeting of PI3Kγ, a key m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::b03f09ff07f87d79aa702b75a4cd4035
http://www.escholarship.org/uc/item/7rs726zj

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PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.

Autor: Schmid MC; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. M.Schmid@liverpool.ac.uk., Kang SW; Department of Life Science, Ewha Womans University, Seoul, 03760, Republic of Korea., Chen H; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Paradise M; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Ghebremedhin A; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Kaneda MM; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Chin SM; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Do A; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Watterson DM; Department of Pharmacology, Northwestern University, Chicago, IL, USA., Varner JA; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. jvarner@health.ucsd.edu.; Department of Pathology and Medicine, University of California, San Diego, La Jolla, CA, USA. jvarner@health.ucsd.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 01; Vol. 13 (1), pp. 1768. Date of Electronic Publication: 2022 Apr 01.

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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response.

Autor: Li J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Kaneda MM; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Ma J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Li M; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Shepard RM; Moores Cancer Center, University of California San Diego, La Jolla, CA 92037., Patel K; Department of Neurosurgery, University of California, Los Angeles, CA 90095., Koga T; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Sarver A; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455., Furnari F; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA., Xu B; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Dhawan S; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Ning J; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Zhu H; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Pediatrics, The First Hospital of China Medical University, Shenyang 110122, China., Wu A; Department of Neurosurgery, The First Hospital of China Medical University, Shenyang 110122, China., You G; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455.; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China., Jiang T; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China., Venteicher AS; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455., Rich JN; Department of Medicine, Division of Regenerative Medicine, University of California San Diego, La Jolla, CA 92093., Glass CK; Department of Medicine, University of California San Diego, La Jolla, CA 92093., Varner JA; Department of Pathology, University of California San Diego, La Jolla, CA 92161., Chen CC; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455; ccchen@umn.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 20; Vol. 118 (16).

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Integrin CD11b activation drives anti-tumor innate immunity.

Autor: Schmid MC; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Khan SQ; Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA., Kaneda MM; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Pathria P; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Shepard R; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Louis TL; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Anand S; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA., Woo G; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Leem C; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA., Faridi MH; Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA., Geraghty T; Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA., Rajagopalan A; Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA., Gupta S; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Ahmed M; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Vazquez-Padron RI; Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, 33136, USA., Cheresh DA; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA., Gupta V; Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA. vineet_gupta@rush.edu., Varner JA; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA. jvarner@ucsd.edu.; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA. jvarner@ucsd.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Dec 19; Vol. 9 (1), pp. 5379. Date of Electronic Publication: 2018 Dec 19.

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Akademický článek

PI3Kγ Activates Integrin α 4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.

Autor: Foubert P; Moores UCSD Cancer Center, University of California, San Diego, California., Kaneda MM; Moores UCSD Cancer Center, University of California, San Diego, California., Varner JA; Moores UCSD Cancer Center, University of California, San Diego, California. jvarner@ucsd.edu.; Department of Pathology, University of California, San Diego, California.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2017 Nov; Vol. 5 (11), pp. 957-968. Date of Electronic Publication: 2017 Sep 28.

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Akademický článek

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

Autor: Sato-Kaneko F; Moores Cancer Center, UCSD, La Jolla, California, USA., Yao S; Moores Cancer Center, UCSD, La Jolla, California, USA., Ahmadi A; Moores Cancer Center, UCSD, La Jolla, California, USA., Zhang SS; Moores Cancer Center, UCSD, La Jolla, California, USA., Hosoya T; Moores Cancer Center, UCSD, La Jolla, California, USA., Kaneda MM; Moores Cancer Center, UCSD, La Jolla, California, USA., Varner JA; Moores Cancer Center, UCSD, La Jolla, California, USA., Pu M; Moores Cancer Center, UCSD, La Jolla, California, USA., Messer KS; Moores Cancer Center, UCSD, La Jolla, California, USA., Guiducci C; Dynavax Technologies Corporation, Berkeley, California, USA., Coffman RL; Dynavax Technologies Corporation, Berkeley, California, USA., Kitaura K; Repertoire Genesis Inc., Saito Bioincubator, Saito-Asagai, Ibaraki-shi, Osaka, Japan., Matsutani T; Repertoire Genesis Inc., Saito Bioincubator, Saito-Asagai, Ibaraki-shi, Osaka, Japan., Suzuki R; Repertoire Genesis Inc., Saito Bioincubator, Saito-Asagai, Ibaraki-shi, Osaka, Japan., Carson DA; Moores Cancer Center, UCSD, La Jolla, California, USA., Hayashi T; Moores Cancer Center, UCSD, La Jolla, California, USA., Cohen EE; Moores Cancer Center, UCSD, La Jolla, California, USA.

Publikováno v: JCI insight [JCI Insight] 2017 Sep 21; Vol. 2 (18). Date of Electronic Publication: 2017 Sep 21 (Print Publication: 2017).

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